Peripheral T-Cell Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we identified human CD1d-restricted lymphoma cells within Vδ1 TCR-expressing PTCL.
|
27069116 |
2016 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Accurate detection of the tumor clone in peripheral T-cell lymphoma biopsies by flow cytometric analysis of TCR-Vβ repertoire.
|
22627740 |
2012 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Molecular staging in PB and BM by TCR gamma PCR at diagnosis may serve as a useful prognostic tool in PTCL.
|
18231909 |
2008 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We present here two rare cases of peripheral T-cell lymphoma (PTCL) based on chronic thyroiditis with the phenotype CD3+, CD4+, CD8-, TCR+.
|
17405755 |
2007 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The combination of TCRVbeta polymerase chain reaction and immunohistochemistry may facilitate more reliable detection and characterization of tumor cells in PTCL.
|
16237215 |
2005 |
Peripheral T-Cell Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The lesion was diagnosed as non-Hodgkin's lymphoma by endoscopic biopsy and classified as peripheral T-cell lymphoma, unspecified, due to clonal rearrangement of the T-cell receptor beta (TCR) gene and expression of TCR beta protein in the absence of B-cell genotypes and phenotypes.
|
12634958 |
2003 |
Peripheral T-Cell Lymphoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The lack of CD3 and TCRAB membrane expression on otherwise phenotypically normal mature T lymphocytes together with the absence of detectable TCRBV mRNA and clonal rearrangement of TCRB gene suggested that the abnormal lymphocyte population was the expression of a peripheral T-cell lymphoma with an indolent clinical course.
|
8608231 |
1996 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our case showed TCR beta rearrangement indicating that the above phenotype can be associated with a peripheral T-cell lymphoma.
|
7485082 |
1995 |
Peripheral T-Cell Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further study of PTCL and related entities are needed to establish whether expanded TcR families are common in those cases that fail to exhibit clonal TcR gene rearrangement.
|
1560311 |
1992 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Interestingly, in the third group of 10 cases of silent PTCL, 5 cases were found to have a TCR gene configuration identical to that in the TCR alpha beta PTCL, as demonstrated by biallelic delta gene deletion.These 5 cases were CD3 positive.
|
1991851 |
1991 |
Peripheral T-Cell Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All three lymphoblastic lymphomas and only 4/11 peripheral T-cell lymphomas (PTCL) cases revealed T-cell receptor (TcR) gene rearrangements.
|
1766259 |
1991 |
Peripheral T-Cell Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heterogeneity of phenotype and genotype were observed in peripheral T cell lymphomas: one out of six cases showed TcR gene rearrangement, one case retained its germline configuration, a further case masked B cell lymphoma and the remainder were polyclonal.
|
2143202 |
1990 |
Peripheral T-Cell Lymphoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Taken together, our results suggest that TCR gene rearrangement is correlated with surface marker data and shows that in some cases PTL may arise from a very early stage of thymocyte maturation.
|
2470614 |
1989 |
Peripheral T-Cell Lymphoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that certain cases of peripheral T-cell lymphoma may lack rearrangements of TCR genes--particularly those cases expressing restricted numbers of T-lineage antigens.
|
3258126 |
1988 |