|
Acquired Hypogammaglobulinemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
Accelerated Loss of TCR Repertoire Diversity in Common Variable Immunodeficiency.
|
27481850 |
2016 |
|
Acquired Immunodeficiency Syndrome
|
0.020 |
GeneticVariation
|
group |
BEFREE |
We describe three cases of immunodeficiency-associated lymphomas, two in patients with acquired immunodeficiency syndrome (AIDS) and one in a patient with a renal transplant, in which both immunoglobulin and TCR gene rearrangements were identified.
|
7943530 |
1994 |
|
Acquired Immunodeficiency Syndrome
|
0.020 |
Biomarker
|
group |
BEFREE |
TCR usage may significantly influence CD8+ T cell-mediated control of AIDS viruses; however, the potential to modulate the repertoire of functional virus-specific T cells by immunotherapy has not been explored.
|
17579081 |
2007 |
|
Active tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A Diverse Lipid Antigen-Specific TCR Repertoire Is Clonally Expanded during Active Tuberculosis.
|
29914888 |
2018 |
|
Acute anterior uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
IL-17F, GM- CSF, and IL-22 represent potentially novel targets in AAU.<i>Conclusion:</i> Our report is arguably the first to implicate IL-17F or ILC-3 and MAIT cells in the pathogenesis of AAU.<b>Abbreviations</b> AAU: acute anterior uveitis; AxSpA: axial spondyloarthritis; BASDAI: Bath ankylosing spondylitis disease activity index; CCR: chemokine receptor; DMSO: dimethylsulfoxide; EULAR:European League Against Rheumatism; FACS: fluorescence activated cell sorter; FBS: fetal bovine serum; FSC: orward light scatter; GM-CSF: granulocyte-macrophage colony stimulating factor; HC: healthy control; ILC: innate lymphoid cell; KIR: killer immunoglobulin receptor; MAIT: mucosal associated immune T cell; ND: not detected; NK: natural killer cell; OHSU-Oregon Health & Science University; PBMC: peripheral blood mononuclear cell; SSC: side light scatter; TCR: T cell receptor.
|
31763950 |
2019 |
|
Acute biphenotypic leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Although most AMLL cases with lymphoid morphology had Ig and TCR gene rearrangements associated with a variety of immunophenotypes and karyotypes, two Ph+ AMLL-ALL cases had many similar features (B/My immunophenotype; IgH with or without TCR rearrangements; Ig light chain genes germline) to their Ph+ AMLL-AML counterparts.
|
2033959 |
1991 |
|
Acute biphenotypic leukemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements, correlating with myeloid-lymphoid immunophenotype in AMLL, support the hypothesis of lineage infidelity of early progenitor cells, rather than the aberrant antigen expression.
|
11342300 |
2001 |
|
Acute GVH disease
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The incidences of grades 2 to 4 acute graft-versus-host disease (GVHD) in the TCR and CD34 groups were 28% and 29%, respectively, and 21% and 10% (<i>P</i> = .1), respectively, for extensive chronic GVHD.
|
29431621 |
2018 |
|
Acute GVH disease
|
0.020 |
Biomarker
|
disease |
BEFREE |
Results show that both aGVHD and minimal residual disease (MRD) eradication did significantly affect TCR gamma/delta profile.
|
16249028 |
2006 |
|
Acute infectious disease
|
0.020 |
Biomarker
|
group |
BEFREE |
Notwithstanding, P. brasiliensis-infected mice showed an increased frequency of prohibitive TCR-expressing T cells in the spleens, suggesting that the selection processes that occur in the thymus may be compromised during the acute infection.
|
27189089 |
2016 |
|
Acute infectious disease
|
0.020 |
Biomarker
|
group |
BEFREE |
However, in the context of chronic infections, it is unclear what the overall profile of TCR affinity for Ag is and if it differs from acute infections.
|
29777029 |
2018 |
|
Acute leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In order to clarify whether HTLV-I plays a role as a virus-encoded superantigen in the neoplastic process, we examined the TCR V beta families in the peripheral blood at four different clinical stages: carrier, smoldering leukemia, chronic leukemia, and acute leukemia.
|
8638605 |
1996 |
|
Acute leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
By screening for immunoglobulin (Ig) and T-cell receptor (TCR) gene rearrangements in bone marrow samples aspirated at different time points during the course of disease from 43 patients with acute leukaemia we have analysed the extent of clonal evolution after autologous bone marrow transplantation (ABMT) and addressed the issue of whether the Southern Blot method has the power to reveal clonal proliferations representing minimal residual disease (MRD) in the autologous bone marrow grafts.
|
8698127 |
1996 |
|
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
To examine the distribution of rearrangements of the gamma- and beta-chain T-cell receptor (TCR) genes in T- and non-T acute lymphoblastic leukemias (ALLs), and potentially to determine which genes rearrange first in ontogeny, we analyzed high molecular weight DNA from 102 patients with acute leukemia.
|
2955409 |
1987 |
|
Acute leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Five cases of acute leukemia (AL) with the t(4;11) translocation were investigated for the immunoglobulin heavy chain, kappa, lambda, TCR beta and TCR gamma gene rearrangements.
|
1375695 |
1992 |
|
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
PCR-based monitoring of minimal residual disease (MRD) in acute leukemias can be achieved via detection of fusion gene transcripts of chromosome aberrations or detection of immunoglobulin (Ig) and T cell receptor (TCR) gene rearrangements.
|
11896540 |
2002 |
|
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
T-cell receptor delta (TCR-delta) gene rearrangement was studied in 40 cases of acute leukaemia and lymphoma of T-cell lineage at diagnosis.
|
8756082 |
1996 |
|
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Its use allowed detection of previously unsuspected TCR alpha/delta rearrangements in 4/13 (30%) immature T-lineage acute leukemias, including two t(10;14) and 2 minor inversion 14s.
|
9242557 |
1997 |
|
Acute leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Inappropriately rearranged IgH or TCR genes are usually not expressed at the mRNA level, and the gene for the TCR associated protein T3 delta is not detectably expressed at the mRNA or protein level in leukemias classified unambiguously as non-T. Five cases of acute leukemia with ambiguous or mixed lineage immunophenotypes (myeloid + T or myeloid + B) are described.
|
3118113 |
1987 |
|
Acute leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
In this study, we analysed 49 children with acute leukaemia (29 B-precursor acute lymphoblastic leukaemia (ALL), 5 relapsed cALL, 6 T-ALL, 7 acute non-lymphocytic (ANLL) and 2 mixed lineage leukaemias), for the presence of different immune system gene rearrangements (Ig JH, C kappa, C lambda, TCR J gamma, C beta, J delta and J alpha) by Southern blot hybridisation.
|
7786608 |
1995 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We next analyzed TCR delta rearrangements in five CD3+TCR gamma/delta+ ALL and cell lines.
|
2547833 |
1989 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
An order of TCR gene rearrangements was observed in T-ALL, with the rearrangement of delta gene preceding that of gamma gene.
|
8187567 |
1994 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Microsatellite markers and fluorescence in situ hybridization identified deletions of the unrearranged TEL allele and IGH/TCR gene rearrangements were analyzed; the results show that posttreatment relapse cells in 2 patients with TEL-AML1-positive ALL were not derived from the dominant clone present at diagnosis but were from a sibling clone.
|
11468150 |
2001 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
A case of acute lymphoblastic leukemia (ALL) was encountered in which the two clonal gamma T-cell receptor gene (TCR gamma) rearrangements found in bone marrow (BM) samples at relapse both differed from the single clonal TCR gamma rearrangement present in BM obtained at diagnosis 5 years previously.
|
1309670 |
1992 |
|
Acute lymphocytic leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since TEL-AML1 has been reported to induce cell cycle retardation and thus may influence somatic recombination, we analyzed 214 TEL-AML1-positive ALL by PCR for rearrangements of the immunoglobulin (Ig) and T-cell receptor (TCR) genes.
|
14574333 |
2004 |