|
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In this study, we report the use of a recombinant adenovirus vector to induce regulatory responses for the prevention of autoimmune diseases through transient expression of a TCR beta-chain.
|
12517939 |
2003 |
|
Autoimmune Diseases
|
0.100 |
AlteredExpression
|
group |
BEFREE |
To investigate the role of gammadelta T cells in human autoimmune disease we expressed and characterized a gammadelta TCR from an autoimmune tissue lesion.
|
12077283 |
2002 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
A vast majority of systemic lupus erythematosus (SLE) patients display decreased expression of TCR zeta-chain mRNA, a critical signaling molecule implicated in the selection of the TCR repertoire and in the prevention of autoimmunity.
|
11247639 |
2001 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
E2F2-deficient T lymphocytes exhibit enhanced TCR-stimulated proliferation and a lower activation threshold, leading to the accumulation of a population of autoreactive effector/memory T lymphocytes, which appear to be responsible for causing autoimmunity in E2F2-deficient mice.
|
11754817 |
2001 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
T cells involved in autoimmune diseases have been characterized by the genetic elements used to construct their autoimmune TCR.
|
10360969 |
1999 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In organ-specific autoimmune diseases, T cells involved in the disease development bear a particular type of TCR and infiltrate the target organ predominantly.
|
9754562 |
1998 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Determination of immunodominant epitopes of MHC class I-restricted self-Ags and elucidation of TCR contact residues is of potential importance in providing a means of manipulating the immune response to self-Ags in human autoimmune diseases.
|
9366420 |
1997 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
There has been considerable interest in the possible restriction of the TCR repertoire in autoimmune disorders, because it would have important therapeutic implications.
|
9100586 |
1997 |
|
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
This review will outline the genomic organization of the TCR genes, the genetic mechanisms responsible for the generation of diversity, and the results of investigations into the association between germline polymorphisms and autoimmune disease.
|
8732480 |
1996 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Understanding the immune response to myelin antigens in regard to the peptide/MHC/TCR complex is important in defining pathogenesis of demyelinating autoimmune diseases and in developing antigen-specific therapies.
|
7544075 |
1995 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The striking similarities in the induction and characteristics of rodent and human T cells specific for TCR peptides support the generality of the observation, and enhance the probability that this immunoregulatory mechanism will have application in human organ-specific autoimmune diseases that are characterized by oligoclonal expression of TCR V genes.
|
8059014 |
1994 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Synthetic TCR V region peptides can induce T cell immunity safely in humans and may prove useful in treating human autoimmune diseases.
|
7510746 |
1994 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TCR V gene usage in autoimmunity.
|
7536011 |
1994 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
The extensive parallels between human T cells specific for V beta 5.2 and V beta 6.1 CDR2 peptides and rat T cells specific for V beta 8.2 CDR2 peptide that are highly protective against experimental encephalomyelitis strengthen the rationale for the therapeutic use of TCR peptides in human autoimmunity.
|
7510747 |
1994 |
|
Autoimmune Diseases
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Mixed connective tissue disease (MCTD) and systemic lupus erythematosus (SLE) are autoimmune diseases with a genetic background, and it is reasonable to suggest that aberrations in T cell receptor (TCR) genes could contribute to these diseases, as they play an important role in immune regulation.
|
7912940 |
1994 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TCR peptides may be useful in the treatment of human autoimmune diseases, providing that disease-relevant V genes can be identified.
|
7686833 |
1993 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
There has been considerable interest recently in the possible restriction of the TCR repertoire in autoimmune disorders, because such restriction would have important therapeutic implications.
|
8376808 |
1993 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
Further studies on the characterization of the specific antigens involved in autoimmune disease pathogenesis is required in order to accurately address the issue of TCR utilization in autoimmune diseases.
|
8357184 |
1993 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
In as much as these TCR have been implicated in a number of experimental autoimmune diseases, MAM may represent an ideal model to evaluate the role of superantigens in the triggering of autoimmune disease.
|
8468471 |
1993 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
However, there are still many important questions to be addressed, such as the nature of thymic education, tolerance, the mechanism of MHC-restricted antigen recognition and the relation between TCR repertoire and autoimmunity.
|
2150969 |
1990 |
|
Autoimmune Diseases
|
0.100 |
Biomarker
|
group |
BEFREE |
TCR gene usage is also restricted in experimental autoimmune disease, in T cells within organs like skin and other epithelial tissues, and in the brain of patients with multiple sclerosis (MS).
|
2382141 |
1990 |