melanoma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
melanoma
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
melanoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Reverse transcriptase-polymerase chain reaction experiments were performed using primers within the reverse transcriptase domain of human telomerase reverse transcriptase and revealed the presence of multiple alternatively spliced transcripts in melanoma specimens.
|
11407973 |
2001 |
melanoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Human telomerase reverse transcriptase-transduced human cytotoxic T cells suppress the growth of human melanoma in immunodeficient mice.
|
15026357 |
2004 |
melanoma
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Expanding the clinical phenotype of autosomal dominant dyskeratosis congenita caused by TERT mutations.
|
18460650 |
2008 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Finally, we report conclusive evidence that rs401681[C] in the TERT-CLPTM1L locus confers susceptibility to BCC but protects against melanoma.
|
19578363 |
2009 |
melanoma
|
0.700 |
Therapeutic
|
disease |
CTD_human |
Inhibition of melanoma growth by subcutaneous administration of hTERTC27 viral cocktail in C57BL/6 mice.
|
20856939 |
2010 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
After correction for multiple testing within each gene, two SNPs in the TERT gene (rs2853676 and rs2242652) and one SNP in the TRF1 gene (rs2981096) showed significant associations with the risk of melanoma.
|
21116649 |
2011 |
melanoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Conversely, all immortal melanoma cultures expressed telomerase reverse transcriptase and telomerase, showing aneuploidy.
|
21418545 |
2011 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In particular, mutations of the telomere binding proteins alpha thalassemia/mental retardation syndrome X-linked (ATRX) or death-domain associated protein (DAXX) have been shown to underlie a telomere maintenance mechanism not involving telomerase (alternative lengthening of telomeres), and point mutations in the promoter of the telomerase reverse transcriptase (TERT) gene increase telomerase expression and have been shown to occur in melanomas and a small number of other tumors.
|
23530248 |
2013 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 (71%) melanomas examined.
|
23348506 |
2013 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Hot spot mutations in the promoter region of telomerase reverse transcriptase (TERT promoter mutations) occur frequently in tumors of neuroectodermal origin such as melanoma and glioma.
|
25035100 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In the melanoma dataset, two pancreatic cancer susceptibility variants were associated: NR5A2 (rs12029406; OR, 1.39; 95% CI, 1.01-1.92; P = 0.04) and CLPTM1L-TERT (rs401681; OR, 1.16; 95% CI, 1.01-1.34; P = 0.04).
|
24642353 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The recent identification of driver mutations in the promoter of the telomerase reverse transcriptase (TERT) gene with UV-induced cytidine-to-thymidine transitions in cutaneous melanoma prompted us to investigate whether these mutations also occur in uveal melanoma.
|
24423917 |
2014 |
melanoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Recurrent and mutually exclusive C>T or CC>TT transition mutations were identified in the promoter region of the reverse transcriptase catalytic subunit of the telomerase gene (TERT) in melanoma recently, and it was suggested that they enhanced the expression of TERT gene and played important roles in the melanoma pathogenesis.
|
24588324 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The four-color FISH probe detected 85.3% of melanomas and 29.4% of TERT and AURKA copy number gains.
|
24374110 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma.
|
24569790 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mutation in the core promoter of the telomerase reverse transcriptase (TERT) gene was determined to be a frequent event in malignant melanoma and other cancers.
|
24866078 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Two recent publications report the identification of a set of recurrent mutations in melanoma in the promoter of the telomerase reverse transcriptase gene (TERT) that appears to be the result of mutagenesis from ultraviolet (UV) radiation.
|
24030752 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We also obtained significant results when we tested the association between rs401681 variant (TERT-CLPTM1L locus) with melanoma risk (Odds ratio, OR; 95% confidence interval, CI=1.24 (1.08-1.43); p-value, 3×10(-3)).
|
25457634 |
2014 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The recently described telomerase reverse transcriptase (TERT) promoter mutations are recurrent in cutaneous melanoma.
|
26055532 |
2015 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The recent identification of a high frequency of driver mutations in the promoter of the telomerase reverse transcriptase (TERT) gene in cutaneous melanoma led us to investigate whether these mutations also occur in SNMM.
|
25746036 |
2015 |
melanoma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We observed statistically significant associations with melanoma for two lung cancer SNPs in the TERT-CLPTM1L locus (Bonferroni-corrected p<2.8x10-4), replicating known pleiotropic effects at this locus.
|
25789475 |
2015 |
melanoma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Recently, recurrent mutations within the core promoter of the human telomerase reverse transcriptase (TERT) gene generating consensus binding sites for ETS transcription factor family members were described in melanomas and other malignancies (e.g. bladder cancer, hepatocellular carcinoma).
|
25997473 |
2015 |
melanoma
|
0.700 |
Biomarker
|
disease |
BEFREE |
A melanoma-associated molecular pathway was identified, where Ran, Aurora Kinase A (AurkA) and TERT were up-regulated, while c-myc and PTEN were down-regulated.
|
25444926 |
2015 |