|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The relative number of thyroglobulin-binding circulating lymphocytes was elevated in six subjects with Hashimoto's disease.
|
316371 |
1979 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
RGD |
Analysis of the spectrotypes of autoantibodies against thyroglobulin in two rat models of autoimmune thyroiditis.
|
3052944 |
1988 |
|
Hashimoto Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Although GD patients have a higher expectancy for development of autoimmune disorders, and in our 50 patients thyroglobulin and/or microsomal antibodies were detected in 20 (i.e., 40%), we failed to find any increased frequency of specific HLA antigen types known to be associated with juvenile autoimmune thyroiditis.
|
7834897 |
1994 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Comparing patients from different groups with normal subjects, there was a significant response to rhTSHR-ECD and thyroglobulin in GD patients (P < 0.001) and HT patients (P < 0.05), but not in CNG patients (P > 0.1).
|
7533773 |
1995 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our studies show that HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis and implicate Tg as an important autoantigen.
|
9064334 |
1996 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We have prepared IgG kappa and lambda phage display combinatorial libraries from the cervical lymph node of a single Hashimoto's thyroiditis patient with a high anti-Tg titer.
|
8752947 |
1996 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Characterization of a novel H2A(-)E+ transgenic model susceptible to heterologous but not self thyroglobulin in autoimmune thyroiditis: thyroiditis transfer with Vbeta8+ T cells.
|
11716530 |
2001 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Thus, both HLA-DR and -DQ polymorphism exists for hTg in autoimmune thyroiditis.
|
12039412 |
2002 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
The putative GD and HT susceptibility genes include both immune modifying genes (e.g., human leukocyte antigen, cytotoxic T lymphocyte antigen-4) and thyroid-specific genes (e.g., TSH receptor, thyroglobulin).
|
14570752 |
2003 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Patients with HT have positive antibodies to thyroglobulin and/or to thyroperoxidase in blood.
|
16444160 |
2003 |
|
Hashimoto Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, missense single-nucleotide polymorphisms (SNPs) in the Tg gene were shown to be associated with autoimmune thyroiditis in both mice and humans.
|
15242677 |
2004 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Human thyroglobulin peptide p2340 induces autoimmune thyroiditis in HLA-DR3 transgenic mice.
|
15927791 |
2005 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Upon immunization with a suboptimal dose of mouse thyroglobulin, IL-12 transgenic mice developed a lymphocytic thyroiditis that was more frequent and severe than that observed in wild-type littermates.
|
15860554 |
2005 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
We examined the heritability of autoantibodies to glutamic acid decarboxylase (GAD65) in type 1 diabetes, and to thyroglobulin (Tg) in chronic lymphocytic thyroiditis and thyrotoxicosis, using regression of offspring on midparent (ROMP) methods.
|
16206515 |
2005 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
It has been reported that serum of patients with RTH lacks autoantibodies against thyroglobulin (Tg) and thyroid peroxidase (TPO), except in rare cases where there is co-occurrence of coincidental autoimmune thyroiditis.
|
16723809 |
2006 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Hyperthyroidism in Graves' disease is caused by thyroid-stimulating autoantibodies to the TSH receptor (TSHR), whereas hypothyroidism in Hashimoto's thyroiditis is associated with thyroid peroxidase and thyroglobulin autoantibodies.
|
17823263 |
2007 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
No significant association has been found with either polymorphisms.Nevertheless, SSc patients without concomitant Hashimoto's thyroiditis (HT) were carrying both the -318T allele (P = 0.031) and the +49 G allele (P = 0.076) more frequently than SSc patients with HT [defined by positivity for anti-thyroperoxidase (TPO) and anti-thyroglobulin (TGA) autoantibodies] than controls.
|
17459075 |
2007 |
|
Hashimoto Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined the genomic region (11.5cM) containing the Tg gene by genotyping seven microsatellite markers and four SNPs located respectively at exon 10 (Ser715Ala), exon 12 (Met1009Val), exon 21 (Ala1483Ala) and exon 33 (Arg1980Trp) in 15 Tunisian multiplex families affected with AITD including Graves' disease (GD) and Hashimoto's thyroiditis (HT) (members: 87; patients: 27 GD and 16 HT).
|
18656705 |
2008 |
|
Hashimoto Disease
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Following lymphocyte stimulation, Tg mRNA levels were observed to be increased 2.7-fold in Graves' disease and 1.6-fold in chronic thyroiditis compared to healthy subjects.
|
18243140 |
2008 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
A novel H2A-E+ transgenic model susceptible to human but not mouse thyroglobulin-induced autoimmune thyroiditis: identification of mouse pathogenic epitopes.
|
18489063 |
2008 |
|
Hashimoto Disease
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In addition, the association of one SNP haplotype with HT suggests that Tg may be an AITD susceptibility gene.
|
19034705 |
2008 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Subclass analysis of thyroglobulin autoantibodies indicated that IgG2 was dominant in autoimmune thyroiditis.
|
20087681 |
2010 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Characterization of thyroglobulin epitopes in Sardinian adults and juveniles with Hashimoto's thyroiditis: evidence against a major effect of age and genetic background on B-cell epitopes.
|
19912245 |
2010 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
Our work shows the association between the thyroglobulin gene and autoimmune thyroiditis and reinforce that thyroglobulin is a thyroid-specific susceptibility gene for this disease.
|
20960158 |
2010 |
|
Hashimoto Disease
|
0.600 |
Biomarker
|
disease |
BEFREE |
In conclusion, our work showed the association between the thyroglobulin gene and autoimmune thyroiditis in Argentinian population and supports the described evidence of thyroglobulin as a thyroid-specific gene linked to AITD.
|
20972722 |
2010 |