Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Osteoporosis and transforming growth factor-beta-1 gene polymorphism in Chinese men and women.
|
14999526 |
2004 |
Osteoporosis
|
0.600 |
Biomarker
|
disease |
CTD_human |
TGF-beta1 is commonly associated with a single base change resulting in a Leu(10)-->Pro (T(869)-->C) polymorphism and is a genetic marker for susceptibility to osteoporosis.
|
12706579 |
2003 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
TGF-beta1 is commonly associated with a single base change resulting in a Leu(10)-->Pro (T(869)-->C) polymorphism and is a genetic marker for susceptibility to osteoporosis.
|
12706579 |
2003 |
Osteoporosis
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Cistanches Herba aqueous extract affecting serum BGP and TRAP and bone marrow Smad1 mRNA, Smad5 mRNA, TGF-β1 mRNA and TIEG1 mRNA expression levels in osteoporosis disease.
|
23232713 |
2013 |
Osteoporosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Effects of Acupoint Application Therapy with TianGui Powder on Osteoporosis in Ovariectomized Rats through TGF-β1 and Smad2/3 Signaling Pathway.
|
30834706 |
2019 |
Osteoporosis
|
0.600 |
Therapeutic
|
disease |
RGD |
Growth hormone treatment prevents osteoporosis in uremic rats.
|
17647196 |
2007 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
I review here the association of transforming growth factor-beta1 gene polymorphisms with genetic susceptibility to osteoporosis, which has provided insight into the function of transforming growth factor-beta1 as well as into the role of genetic factors in the development of osteoporosis.
|
11740340 |
2001 |
Osteoporosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
I review here the association of transforming growth factor-beta1 gene polymorphisms with genetic susceptibility to osteoporosis, which has provided insight into the function of transforming growth factor-beta1 as well as into the role of genetic factors in the development of osteoporosis.
|
11740340 |
2001 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In the present study, we identified four new polymorphisms in TGFB1 and examined whether these polymorphisms are risk factors for osteoporosis.
|
12938093 |
2003 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the association between osteoporosis and interleukin 10 (IL-10) -597 C > A and transforming growth factor β1 (TGF-β1) T869C (also named Leu10 > Pro) polymorphisms in Turkish postmenopausal women.
|
23583365 |
2013 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study.
|
18284942 |
2008 |
Osteoporosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
One of the candidate genes involved in osteoporosis is the transforming growth factor beta-1 (TGFB1) whose polymorphisms may be responsible for the development of this disease.
|
28993955 |
2017 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the transforming growth factor beta 1 gene and osteoporosis.
|
12667558 |
2003 |
Osteoporosis
|
0.600 |
AlteredExpression
|
disease |
LHGDN |
Results indicate that persons with osteoporosis have an increased oxidative stress that is not accompanied by changes in TGF-beta1 levels.
|
17341610 |
2006 |
Osteoporosis
|
0.600 |
Biomarker
|
disease |
BEFREE |
Significant correlations with BTM were shown for IL-1α and IFN-γ in OP (rho = 0.608 and -0.634) and for TNF-α, IL-6 and transforming growth factor-β1 (TGF-β1) in OA (rho = 0.591, -0.521 and 0.636).
|
22380539 |
2012 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The lack of association between the common genetic variations of TGF-β1 and IL-6 genes, and BMD highlights the complex genetic background of osteoporosis in the north of Iran.
|
29860063 |
2018 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
LHGDN |
The aim of our study was to determine serum TGF-beta1 levels in male patients with idiopathic osteoporosis.
|
17598964 |
2007 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was therefore to examine whether possible variants of the TGF-beta 1 gene are related to bone mass and osteoporosis.
|
9071481 |
1997 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study is to evaluate the role of the two polymorphism of transforming growth factor-β1 T869C and C-509T in developing osteoporosis in postmenopausal Egyptian women.
|
29208173 |
2017 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The examined SNPs (MTHFR (C677T, and A1298C), TGFβ1 (T869C), and TNFB (A252G)) were tested by genotyping 17 RA patients with OP and 72 RA patients without OP.
|
25981594 |
2015 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of vertebral fracture in 168 postmenopausal female patients with osteoporosis was analyzed, and its association with the TGF-beta1 gene polymorphism and serum 25(OH)D concentration was assessed cross-sectionally.
|
20052600 |
2010 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The T29-->C polymorphism of the TGFbeta1 gene exhibited inverse patterns of association with genetic susceptibility to spinal osteophytosis and with osteoporosis.
|
10693888 |
2000 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that allelic variation at the TGF-beta 1 gene contributes to the development of osteoporosis at the hip.
|
11157141 |
2001 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the C-509-->T polymorphism, alone or in combination with the T869-->C polymorphism, of the transforming growth factor-beta1 gene is a genetic determinant of bone mass, and that the number of T alleles in the combined genotype is a risk factor for the genetic susceptibility to osteoporosis in postmenopausal Japanese women.
|
11357939 |
2001 |
Osteoporosis
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Thus, analysis of the TGF-beta1 genotype may be useful in the prevention and management of osteoporosis.
|
9783545 |
1998 |