|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
This study confirms tissue transglutaminase C as a major autoantigen in coeliac disease and describes novel radiobinding assays for large scale testing to identify cases of coeliac disease.
|
10028022 |
1999 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
We have developed a radioassay for autoantibodies to tissue transglutaminase (tTG) following the report that this enzyme is 'the' endomysial autoantigen (EMA) of celiac disease.
|
10441179 |
1999 |
|
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
No polymorphism in the tissue transglutaminase gene detected in coeliac disease patients.
|
10672836 |
2000 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Consistent with earlier reports indicating that host tissue transglutaminase modification of gliadin enhances gliadin-specific CD T-cell responses, tissue transglutaminase specifically deamidated Q65 in the peptide of A-gliadin amino acids 56-75.
|
10700238 |
2000 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These complexes may permit gluten-reactive T cells to provide help to tTG-specific B cells by a mechanism of intramolecular help, thereby explaining the occurrence of gluten-dependent tTG autoantibodies that is a characteristic feature of active CD.
|
10837052 |
2000 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Molecular dissection of the tissue transglutaminase autoantibody response in celiac disease.
|
11238668 |
2001 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Autoantibodies from patients with coeliac disease recognize distinct functional domains of the autoantigen tissue transglutaminase.
|
11529912 |
2001 |
|
Celiac Disease
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
There is no evidence from this study that mutations in TGM2, which lead to an altered protein, contribute to CD susceptibility.
|
11742196 |
2001 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In addition to providing a quantitative framework for understanding the role of tTGase in Celiac Sprue, our results lay the groundwork for the design of small molecule mimetics of gliadin peptides as selective inhibitors of tTGase.
|
11772038 |
2002 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Our results indicate that the tTG gene can be excluded as a major primary genetic factor in CD pathogenesis.
|
11774946 |
2001 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
The correlation of endomysial and tissue transglutaminase antibodies and the correlation of endomysial antibodies to the HLA typical for coeliac disease was determined.
|
11843051 |
2002 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Gliadin T cell epitope selection by tissue transglutaminase in celiac disease. Role of enzyme specificity and pH influence on the transamidation versus deamidation process.
|
12093810 |
2002 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
In EMA-positive subjects, human tissue transglutaminase IgA antibodies and CD-associated human leukocyte antigen DQ2/DQ8 haplotypes were determined.
|
12578508 |
2003 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
For both groups, serologic screening for CD was performed through antiendomysium (EMA) and tissue transglutaminase autoantibodies (tTGAA).
|
12658037 |
2003 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Because the 33-mer peptide is not present in cereal proteins that do not cause coeliac disease, Shan and colleagues suggest that generation of this peptide in vivo underlies the specific association between gluten, immune responsiveness, and tissue transglutaminase in coeliac disease.
|
12699968 |
2003 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
There have been a number of advances in our understanding of the pathogenesis of coeliac disease, in particular the mechanisms whereby gluten epitopes are processed, become modified by tissue transglutaminase (tTG) and then interact with HLA restricted T cells.
|
14592529 |
2004 |
|
Celiac Disease
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Celiac disease is a complex autoimmune disease which is characterized by a strong genetic association (HLA-DQ2 or -DQ8), gluten as nutritional etiological factor, and the enzyme tissue transglutaminase as endomysial autoantigen.
|
14600421 |
2003 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
These experiments showed that the tTG N-terminal aa 1-89 were important for tTG Ab binding in all 15 coeliac disease sera studied and the central residues (aa 401-491) were important for binding of tTG Abs in all but one sera.
|
14709413 |
2004 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
One-step cloning of anti tissue transglutaminase scFv from subjects with celiac disease.
|
14709414 |
2004 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Transglutaminase 2 in celiac disease: minireview article.
|
15290344 |
2004 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
CD is strongly associated with HLA-DQ2 and it has recently been established that gut-derived DQ2-restricted T cells from patients with CD predominantly recognize gluten-derived peptides in which specific glutamine residues are deamidated to glutamic acid by tissue transglutaminase.
|
15309343 |
2004 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Tissue transglutaminase and celiac disease.
|
15746535 |
2005 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Celiac disease is driven by intestinal T cells responsive to proline-rich gluten peptides that often harbor glutamate residues formed by tissue transglutaminase-mediated glutamine conversion.
|
15972656 |
2005 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
BEFREE |
Molecular mechanisms responsible for the involvement of tissue transglutaminase in human diseases: Celiac Disease.
|
16146729 |
2006 |
|
Celiac Disease
|
0.400 |
Biomarker
|
disease |
LHGDN |
Unexpected role of surface transglutaminase type II in celiac disease.
|
16285941 |
2005 |