Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Tyrosine hydroxylase (TH, a marker of dopamine-synthesizing cells), NR1 (an NMDA receptor subunit) and GluR5 (a kainate subunit) transcript levels were significantly increased in the SNc in schizophrenia.
|
14969737 |
2004 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A number of studies have suggested an association between schizophrenia and the tryptophan hydroxylase (TPH) and tyrosine hydroxylase (TH) genes.
|
16741719 |
2006 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Among primates, a tyrosine hydroxylase (THO1) intron STR, previously implicated in both schizophrenia and drug withdrawal delirium, exhibited frequent replacements.
|
15656986 |
2005 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
An attractive model to study processes related to neurodevelopment in schizophrenia is reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) and differentiating them into different neuronal lineages. iPSCs from three schizophrenia patients and from two controls were reprogrammed from hair follicle keratinocytes, because of their accessibility and common ectodermal origin with neurons. iPSCs were differentiated into Pax6(+)/Nestin(+) neural precursors and then further differentiated into β3-Tubulin(+)/tyrosine hydroxylase(+)/DAT(+) dopaminergic neurons.
|
23732879 |
2013 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of DNA polymorphism in the first intron of the tyrosine hydroxylase gene with disturbances of the catecholaminergic system in schizophrenia.
|
9075305 |
1997 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Failure to replicate an association between a rare allele of a tyrosine hydroxylase gene microsatellite and schizophrenia.
|
9684913 |
1998 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the dopamine D5 receptor on chromosome 5 and the tyrosine hydroxylase gene on chromosome 11 have both been suggested as candidate genes in schizophrenia and may also be implicated in susceptibility to poor glycaemic control.
|
16459247 |
2005 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Indeed, an association between a rare variant allele of the gene encoding TH and the occurrence of schizophrenia has been found in several populations.
|
8984738 |
1996 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Linkage to schizophrenia was tested by linkage analyses of 6 polymorphic markers (at 4 loci) in chromosome 11p15.5 including the dopamine D4 receptor (DRD4) and the tyrosine hydroxylase (TH) loci.
|
8135305 |
1993 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Mice born with gene knockouts of some possible schizophrenia susceptibility genes are dopamine supersensitive, and their striata reveal markedly elevated D2High states; suchgenes include dopamine-beta-hydroxylase, dopamine D4 receptors, G protein receptor kinase 6, tyrosine hydroxylase, catechol-O-methyltransferase, the trace amine-1 receptor, regulator of G protein signaling RGS9, and the RIIbeta form of cAMP-dependent protein kinase (PKA).
|
16786561 |
2006 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
No association between the tyrosine hydroxylase microsatellite marker HUMTH01 and schizophrenia or bipolar I disorder.
|
9686421 |
1998 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our purpose was to test the dopamine D2 receptor gene (DRD2), the tyrosine hydroxylase (TH) gene and the monoamino oxydase A (MAO-A) gene for linkage to schizophrenia and bipolar disorders.
|
8710185 |
1996 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results provide significant evidence for exclusion for linkage between schizophrenia and the dopamine D4 receptor gene and the TH gene under the models specified.
|
7909222 |
1994 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our study indicates that the TH gene is not likely to play a major role in the genetic predisposition to schizophrenia, mood disorders, or alcohol dependence.
|
9754624 |
1998 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, an association has been reported between schizophrenia and a rare allele containing 10-repeats (A10) of a polymorphic tetranucleotide motif in the first intron of the tyrosine hydroxylase (TH) gene.
|
9564682 |
1998 |
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
TH and aromatic acid decarboxylase (AADC) mRNA and TH protein were unchanged in the midbrain in schizophrenia compared with controls.
|
28094812 |
2017 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of this study is to profile the peripheral biomarkers (tyrosine hydroxylase, TH; interleukin-1beta, IL-1beta; and tumor necrosis factor-alpha, TNF-alpha) for schizophrenia and explore their relations with clinical symptoms.
|
20067853 |
2010 |
Schizophrenia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The combined schizophrenia group had higher TH and GAD67 protein levels than controls (an increase of 69.6%, P=0.01 and 19.5%, P=0.004, respectively).
|
27550734 |
2017 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The present data suggest that the biosynthesis of catecholamine by the action of TH should be deeply involved in decreased intellectual ability in patients with schizophrenia.
|
24417771 |
2014 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results are compatible with the view that the tyrosine hydroxylase, dopamine receptor D2 and D4 gene polymorphisms examined are not of major importance in the aetiology or pathophysiology of schizophrenia.
|
8908411 |
1996 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The revealed differences in the susceptibility to schizophrenia depending on polymorphic allele variants in repetitive TCAT sequence in TH01 locus may be associated with the function of a regulatory element in the process of TH gene transcription.
|
19189602 |
2009 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results indicate that exon 3 of the human TH gene lacks association with schizophrenia in Japanese patients.
|
11326301 |
2001 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results suggest that TH could be considered as a minor gene contributing to the susceptibility of Japanese female schizophrenia.
|
11475015 |
2001 |
Schizophrenia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that the polymorphic intron 1 of the human TH gene may be associated with disturbances of the catecholamine pathway in schizophrenia.
|
7551967 |
1995 |
Schizophrenia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This result does not preclude the possibility that the D4 receptor gene or the TH gene has only a nonmajor effect on the genetic etiology of schizophrenia or that families in other populations are linked.
|
7991733 |
1994 |