THPO, thrombopoietin, 7066

N. diseases: 185; N. variants: 9
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4021790
Disease: Abnormality of the skeletal system
Abnormality of the skeletal system 		0.110 Biomarker disease BEFREE Essential thrombocythemia in a child with elevated thrombopoietin concentrations and skeletal anomalies. 17455310 2008
CUI: C4021790
Disease: Abnormality of the skeletal system
Abnormality of the skeletal system 		0.110 Biomarker disease HPO
CUI: C2931757
Disease: Acquired amegakaryocytic thrombocytopenia
Acquired amegakaryocytic thrombocytopenia 		0.020 Biomarker phenotype BEFREE HCV infection might also induce autoantibodies to c-Mpl, resulting in the development of AAMT. 29085203 2017
CUI: C2931757
Disease: Acquired amegakaryocytic thrombocytopenia
Acquired amegakaryocytic thrombocytopenia 		0.020 Biomarker phenotype BEFREE This rare AATP case presentation highlights the importance of a well-structured diagnostic approach to thrombocytopenia during pregnancy and supports the successful use of thrombopoietin agonists for the management of AATP. 31229978 2019
CUI: C0271907
Disease: Acquired aplastic anemia
Acquired aplastic anemia 		0.010 Biomarker disease BEFREE We measured the endogenous plasma concentration of TPO in 40 patients with acquired aplastic anaemia (AA) and in 32 patients with idiopathic thrombocytopenic purpura (ITP) by a sensitive Sandwich enzyme-linked immunosorbent assay (ELISA) and compared the results. 12150725 2002
CUI: C0154301
Disease: Acquired thrombocytopenia
Acquired thrombocytopenia 		0.010 AlteredExpression disease BEFREE To better understand the pathogenesis of thrombopoiesis in this hereditary thrombocytopenic disorder, we determined the percentage of reticulated platelets (RP), plasma glycocalicin (GC) and thrombopoietin (TPO) levels in 29 patients with CHMT, 23 patients with immune thrombocytopenic purpura (ITP), and 17 patients with thrombocytopenia secondary to decreased bone marrow megakaryocytes (hypoplasia). 10997880 2000
CUI: C0221347
Disease: Acrocyanosis
Acrocyanosis 		0.100 Biomarker phenotype HPO
CUI: C0742343
Disease: Acute Chest Syndrome
Acute Chest Syndrome 		0.010 Biomarker disease BEFREE Modest correlation was revealed between MPV and plasma thrombopoietin (TPO) measured at the first day of ACS (r = 0.279, P = 0.005). 23941967 2014
CUI: C0085669
Disease: Acute leukemia
Acute leukemia 		0.010 AlteredExpression disease BEFREE We studied serum thrombopoietin (TPO) levels and circulating numbers of platelet during five courses of myelosuppressive post-remission chemotherapy in three patients with acute leukemia in complete remission. 9529122 1998
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 AlteredExpression disease BEFREE Primary leukemia cells separated from patients with B-precursor acute lymphoblastic leukemia with Ph1 or 11q23 translocation also showed the surface c-Mpl expression and a significant responsiveness to TPO. 10995006 2000
CUI: C0023462
Disease: Acute Megakaryocytic Leukemias
Acute Megakaryocytic Leukemias 		0.020 Biomarker disease BEFREE The supernatant of the transfected 293T cells stimulated the proliferation of a human megakaryoblastic leukemia cell line (UT-7/TPO) cells in a dose dependent manner, indicating that the feline TPO cDNA obtained in this study encodes biologically active feline TPO. 9880100 1998
CUI: C0023462
Disease: Acute Megakaryocytic Leukemias
Acute Megakaryocytic Leukemias 		0.020 Biomarker disease BEFREE Acute megakaryoblastic leukaemia with 3q inversion and elevated thrombopoietin (TSF): an autocrine role for TSF? 4084458 1985
CUI: C0023465
Disease: Acute monocytic leukemia
Acute monocytic leukemia 		0.010 Biomarker disease BEFREE However, it remains unclear, whether TPO mimetics influence the increase of blast cells and therefore to premature progression to AML. 28962071 2017
CUI: C0001339
Disease: Acute pancreatitis
Acute pancreatitis 		0.010 Biomarker disease BEFREE Our data provide the first evidence for TPO as potential early prognostic biomarker in AP patients. 28079612 2017
CUI: C0220615
Disease: Adult Acute Myeloblastic Leukemia
Adult Acute Myeloblastic Leukemia 		0.010 Biomarker disease BEFREE Here, we show that TPO, interleukin-3 (IL-3) and, at least in short-term assays, also interferon gamma (IFN gamma) induced proliferation in acute myeloid leukemia (AML-M7)-derived M-07e cells. 9766506 1998
CUI: C3900098
Disease: Adult Myelodysplastic Syndrome
Adult Myelodysplastic Syndrome 		0.010 Biomarker disease BEFREE Involvement of transforming growth factor-beta and thrombopoietin in the pathogenesis of myelodysplastic syndrome with myelofibrosis. 16034467 2005
CUI: C1264031
Disease: Alloimmune thrombocytopenia
Alloimmune thrombocytopenia 		0.010 Biomarker disease BEFREE Fetal alloimmune thrombocytopenia allows insight into the biology of TPO when fetal megakaryopoiesis is chronically stimulated. 11446655 2001
CUI: C1879691
Disease: Amegakaryocytosis
Amegakaryocytosis 		0.010 AlteredExpression disease BEFREE A plasma Tpo level <128 AU/ml excludes (negative predictive value 96%, 95% CI 90-99) severe asphyxia, congenital viral infections and amegakaryocytosis as the cause for thrombocytopenia in newborns.Increased plasma Tpo levels indicate that thrombocytopenia in newborns, as a result of various nonimmune disorders, is often caused by (temporary) bone marrow suppression/failure. 30759044 2020
CUI: C0002871
Disease: Anemia
Anemia 		0.010 AlteredExpression disease BEFREE The platelet change ratio (i.e., platelet count at week 4/platelet count at baseline) in the patients with developing anemia was correlated with the increase in the serum EPO level over 4 weeks (r = 0.88, P = 0.002), but not with the increase in the serum TPO level over 4 weeks. 22460221 2012
CUI: C1260899
Disease: Anemia, Diamond-Blackfan
Anemia, Diamond-Blackfan 		0.020 AlteredExpression disease BEFREE Elevated thrombopoietin levels and alterations in the sequence of its receptor, c-Mpl, in patients with Diamond-Blackfan anemia. 15531462 2004
CUI: C1260899
Disease: Anemia, Diamond-Blackfan
Anemia, Diamond-Blackfan 		0.020 Biomarker disease LHGDN We conclude that TPO enhances bone marrow erythropoiesis in patients with DBA in the presence of EPO and SCF and/or IL-3. 12041668 2002
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia 		0.090 Biomarker disease BEFREE For acquired thrombocytopenias, data on TPO in aplastic anemia, immune thrombocytopenia, human immunodeficiency virus infection, and liver disease are given. 11446655 2001
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia 		0.090 GeneticVariation disease LHGDN Thrombopoietin is essential for the maintenance of normal hematopoiesis in humans: development of aplastic anemia in patients with congenital amegakaryocytic thrombocytopenia. 12799278 2003
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia 		0.090 Biomarker disease BEFREE Recombinant Human Thrombopoietin Promotes Platelet Engraftment and Improves Prognosis of Patients with Myelodysplastic Syndromes and Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation. 28642072 2017
CUI: C0002874
Disease: Aplastic Anemia
Aplastic Anemia 		0.090 AlteredExpression disease BEFREE Eighteen of 19 patients with AA and a mean platelet count (MPC) of 18,000/microliters (2,000 to 61,000/microliters) had markedly elevated TPO levels (mean, 1,467 pg/mL; range, 597 to 3,834 pg/mL). 8639762 1996