Aortic Aneurysm, Abdominal
|
0.080 |
Biomarker
|
disease |
BEFREE |
We analyzed the expression of all known MMPs with established elastolytic activity and TIMPs in human AAA and control tissue. mRNA coding for MMP-9, MMP-2, human macrophage metalloelastase, MMP-7, TIMP-1, and TIMP-2 were amplified by reverse transcriptase-PCR in control and AAA tissue.
|
9588507 |
1998 |
Aortic Aneurysm, Abdominal
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We analyzed TIMP1 and TIMP2 coding sequences in 12 individuals with abdominal aortic aneurysms (AAA), one individual with AAA and intracranial aneurysms (IA), four individuals with IA and two clinically unaffected individuals.
|
10372551 |
1999 |
Aortic Aneurysm, Abdominal
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
The remodeling of the aortic wall in AAA and AOD involves gene activation of a large and similar spectrum of proteolytic enzymes while the expression of two physiological inhibitors, TIMP-2 and PAI-1, is significantly lower in AAA compared to AOD.
|
14522424 |
2003 |
Aortic Aneurysm, Abdominal
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Although genes for TIMP-1, -2 and -3 tended to be upregulated in AAA, relative expression levels of MMP-1 to TIMP-1, MMP-1 to TIMP-2, MMP-1 to TIMP-3, and MMP-3 to TIMP-2 were still higher in AAA than in non-dilated regions (1.12 +/- 0.63 versus 0.10 +/- 0.03, 4.13 +/- 1.12 versus 0.43 +/- 0.11, 1.61 +/- 0.59 versus 0.14 +/- 0.03, and 7.81 +/- 1.60 versus 2.56 +/- 0.76, respectively, P < 0.05).
|
15530910 |
2004 |
Aortic Aneurysm, Abdominal
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Decreased TIMP-1 and TIMP-2 expression in the extracellular matrix of the walls of AAAs has been shown in several studies.
|
17899257 |
2007 |
Aortic Aneurysm, Abdominal
|
0.080 |
Biomarker
|
disease |
BEFREE |
Similar mRNA upregulation of TNF-α, interleukin-1β, matrix metalloproteinases (MMP)-2, MMP-9, and tissue inhibitors of metalloproteinases (TIMP)-1 and TIMP-2 was observed in the AAAs, and TG2 and TNF-α were colocalized in the aortic walls at 1 week.
|
20615646 |
2010 |
Aortic Aneurysm, Abdominal
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
The TIMP2 gene promoter polymorphism was evaluated by polymerase chain reaction, followed by restriction enzyme analysis and pyrosequencing in 128 patients affected by AAA and in 180 individuals included as references.
|
24534323 |
2015 |
Aortic Aneurysm, Abdominal
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We compared (1) the histopathological findings in patients with abdominal aortic aneurysms (AAA) and aortoiliac occlusive disease (AOD); (2) the expression of MMP-2/MMP-9 and TIMP-1/TIMP-2 in aortic layers, inflammatory cells and smooth muscle cells (SMCs), aiming to identify the common underlying pathogenic mechanisms of the disease development.
|
29687775 |
2017 |