Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
TLR2 and TLR4 expression during bacterial infections.
|
17100621 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
TLR2 and TLR4 expression during bacterial infections.
|
17100621 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TLR2 recognizes bacterial lipoproteins and plays a central role in the host defense against bacterial infections, including those caused by Staphylococcus aureus.
|
28858870 |
2017 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
TLR2, is also the initial barrier against bacterial infection and plays an important role in recognising a variety of bacterial lipoproteins.
|
29457581 |
2018 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Arg753Gln polymorphism of the human toll-like receptor-2 gene in children with recurrent febrile infections.
|
17554618 |
2007 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Impaired airway innate immunity (e.g., suppressed Toll-like receptor 2 [TLR2] signaling) has been reported in allergic lungs with bacterial infection.
|
21892915 |
2011 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
In this study, we focused on the pathways regulating immune responses in murine macrophages and modeled post viral-bacterial infections through pretreatment of bone marrow-derived macrophages (BMDMs) with a toll-like receptor (TLR) 7/8 ligand (R848) and subsequent challenge with TLR2/4 agonists to mimic bacterial infection.
|
29515583 |
2018 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Increased mast cell IL-6 production in response to combined TLR2 and NLR activation could play a role in the protection against bacterial infection, but potentially exacerbate inflammation-dependent conditions.
|
20861644 |
2011 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Lipoteichoic acid (LTA) and lipoproteins are representative TLR2 ligands that play important roles in bacterial infection and in host inflammatory responses.
|
30176521 |
2018 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, we observed that expression of TLR2 and TLR4 was significantly higher in patients with AML and bacterial infection in comparison with group with separate fungal infection (ΔCt TLR2 1.15 ± 1.06 vs 0.66 ± 0.51 and ΔCt TLR4 0.45 ± 0.38 vs 0.21 ± 0.19).
|
25412934 |
2014 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
MyD88 adapter-like (Mal), also termed TIRAP, is involved in bridging MyD88 to the receptor complex for TLR-2 and TLR4 signaling in response to bacterial infection.
|
19592497 |
2009 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings demonstrate that during bacterial infection in vivo, newborns selectively and coordinately amplify the TLR2-MyD88 pathway in G+ bacterial infection and the TLR4/MD2/MyD88 pathway in G- bacterial infection, suggesting key roles for innate immune pathway in neonatal responses to bacterial infection.
|
20805788 |
2010 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our findings may offer a deliverable approach to attenuate bacterial infections in airways of asthma or chronic obstructive pulmonary disease patients with impaired TLR2 function.
|
21239529 |
2011 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our results confirmed pro-inflammatory function of extracellular Hsp70, and suggest its possible implication in COPD exacerbations caused by bacterial infection through desensitization or inappropriate activation of TLR2 and TLR4 receptors.
|
29067554 |
2018 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Our study indicated that TLR2 activation by infectious bacterial PGN played an important role in breast cancer cell invasiveness and illustrated a new link between infectious bacteria and the cancer cells, suggesting the importance of antibiotic therapy to treat cancer with bacterial infection.
|
20520770 |
2010 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Our study thus provides novel insights into the regulation of TLR2 expression in mixed bacterial infections.
|
18664270 |
2008 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Polymorphisms in TLR2 (Arg753Gln) and TLR4 (Asp299Gly, Thr399Ile) genes are associated with bacterial infections, we therefore studied these polymorphisms in osteomyelitis patients.
|
16487238 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
There was also a moderate positive correlation between the expression Myd88-Tnfrsf11 and Tlr2-Myd88, suggesting the relevance of Tlr2-Myd88 in bone loss due to bacterial infection.
|
29995146 |
2018 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These findings suggest that a mutation in the TLR2 gene may predispose individuals to life-threatening bacterial infections.
|
11035751 |
2000 |
Bacterial Infections
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results have indicated that there is a strong significant relationship between susceptibility to recurrent bacterial infections and Arg753Gln polymorphism of the TLR-2 gene.
|
17554618 |
2007 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
These studies may bring new insight for fully understanding the important role of EGFR signaling in regulating host defense and immune response by tightly controlling TLR2 induction during bacterial infections.
|
16115866 |
2005 |
Bacterial Infections
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This early response to viral capsids required the cell surface-expressed PRR TLR2 and allowed for improved clearance of subsequent bacterial infection that commonly complicates respiratory viral infections.
|
29138299 |
2017 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Thus, TLR2 in association with asialo-glycolipids presented within the context of lipid rafts provides a broadly responsive signaling complex at the apical surfaces of airway cells to initiate the host response to potential bacterial infection.
|
15146246 |
2004 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
BEFREE |
Thus, Ca(2+) participates as a second messenger in TLR2-dependent signaling and provides another target to modulate proinflammatory responses to bacterial infection.
|
16818794 |
2006 |
Bacterial Infections
|
0.100 |
Biomarker
|
group |
LHGDN |
Thus, Ca(2+) participates as a second messenger in TLR2-dependent signaling and provides another target to modulate proinflammatory responses to bacterial infection.
|
16818794 |
2006 |