|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells.
|
31602262 |
2019 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Furthermore, the overexpression of TMPO-α in gastric tissues (56%) was positively associated with Lauren classification (<i>P</i> = 0.0159), nodal status (<i>P</i> = 0.0265), distant metastasis (<i>P</i> < 0.0001), stage (<i>P</i> = 0.0367), and degree of differentiation (<i>P</i> = 0.0009).
|
31602262 |
2019 |
|
prostatitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Differential expression of the TPα and TPβ isoforms of the human T Prostanoid receptor during chronic inflammation of the prostate: Role for FOXP1 in the transcriptional regulation of TPβ during monocyte-macrophage differentiation.
|
31271729 |
2019 |
|
Tumor Progression
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The upregulation of TMPO-AS1, TMPO mRNA and protein levels were associated with tumor progression of NSCLC.
|
31230752 |
2019 |
|
Carcinoma, Large Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Using immunohistochemistry with antibodies for emerin, lamin A/C, lamin B, and LAP2, we examined 105 lung cancer tissues from 33 small cell lung carcinomas (SCLCs) and 72 non-SCLCs (34 adenocarcinomas, 30 squamous cell carcinomas, and 8 large cell carcinomas).
|
31201505 |
2019 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemistry showed that the expression of TMPO-α was significantly higher in GC tissues and cells in comparison with non-tumor tissues and cells.
|
31602262 |
2019 |
|
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In addition, studies conducted in GC cells indicated that knockdown of TMPO-α suppressed cell proliferation and invasion.
|
31602262 |
2019 |
|
Pancreatic Ductal Adenocarcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of thymopoietin by miR-139-5p suppresses cell proliferation and induces cell cycle arrest/apoptosis in pancreatic ductal adenocarcinoma.
|
31516562 |
2019 |
|
Progression of non-small cell lung cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Long noncoding RNA TMPO-AS1 promotes progression of non-small cell lung cancer through regulating its natural antisense transcript TMPO.
|
31230752 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression level of miR-139-5p was inversely associated with the expression of TMPO in PDAC specimens.
|
31516562 |
2019 |
|
Oestrogen receptor positive breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Enhanced expression of <i>ESR1</i> mRNA by <i>TMPO-AS1</i> could play a critical role in the proliferation of ER-positive breast cancer.
|
31501276 |
2019 |
|
Hormone refractory breast cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
<i>ESR1</i>-Stabilizing Long Noncoding RNA <i>TMPO-AS1</i> Promotes Hormone-Refractory Breast Cancer Progression.
|
31501276 |
2019 |
|
Carcinoma, Basal Cell
|
0.010 |
Biomarker
|
disease |
BEFREE |
GLI1 intranuclear trafficking by LAP2 isoforms represents a powerful signal amplifier in BCCs with implications for zinc finger-based signal transduction and therapeutics.
|
30503211 |
2019 |
|
Non-alcoholic Fatty Liver Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Nuclear lamina genetic variants, including a truncated LAP2, in twins and siblings with nonalcoholic fatty liver disease.
|
28902428 |
2018 |
|
Cardiomyopathies
|
0.010 |
Biomarker
|
group |
BEFREE |
To test this, we analyzed RNA-Seq datasets, finding novel isoforms or isoform tissue-specificity for: Lap2, linked to cardiomyopathy; Nesprin 2, linked to Emery-Dreifuss muscular dystrophy and Lmo7, that regulates the Emery-Dreifuss muscular dystrophy linked emerin gene.
|
29912636 |
2018 |
|
Hormone refractory prostate cancer
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, we recently discovered that both TPα and TPβ form functional signalling complexes with members of the protein kinase C-related kinase (PRK) family, AGC- kinases essential for the epigenetic regulation of androgen receptor (AR)-dependent transcription and promising therapeutic targets for treatment of castrate-resistant prostate cancer (CRPC).
|
28108419 |
2017 |
|
Fetal Growth Retardation
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Together our data indicate that expression of TPα mediates normal placentation; however, TPβ impairs placentation, and promotes the development of IUGR, and represents an underappreciated pathogenic factor in humans.
|
27363493 |
2016 |
|
Glioblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study observed that the expression of TMPO in GBM specimens was remarkably higher than that in normal brain specimens.
|
27756319 |
2016 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells.
|
27756319 |
2016 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Depletion of thymopoietin inhibits proliferation and induces cell cycle arrest/apoptosis in glioblastoma cells.
|
27756319 |
2016 |
|
Glioblastoma Multiforme
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This study observed that the expression of TMPO in GBM specimens was remarkably higher than that in normal brain specimens.
|
27756319 |
2016 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Neither the normal nor the benign lesions of the breast showed positive TMPO immunodetection, whilst 45 % of the breast carcinomas were immunopositive (p = 0.000), nine of ten positives carcinomas correspond to the Luminal A subtype.
|
25837847 |
2015 |
|
Carcinoma, Papillary
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In papillary carcinomas (PCs), the nuclear proteins most frequently expressed at high levels were emerin (82 % positive), lamin A/C (64 %), and LAP2 (82 %).
|
26254781 |
2015 |
|
Fibroadenoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
TMPO expression was analyzed by immunohistochemistry in tissue microarray containing 46 breast tissue samples including normal (n = 6), benign lesions (n = 18) (fibroadenomas (n = 6), fibrocystic changes (n = 6), ductal hyperplasias (n = 6)) and breast carcinoma (n = 22).
|
25837847 |
2015 |
|
Medullary carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In all medullary carcinomas (MCs), intermediate to high levels of expression of lamin A/C and LAP2 were found.
|
26254781 |
2015 |