|
Acute infectious disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Among others, the ion of m/z 4963 was the most important to identify acute infection and was tentatively identified as Thymosin β4.
|
28758666 |
2017 |
|
Acute lymphocytic leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
A cDNA clone encoding human thymosin-beta 4 was isolated from a cDNA library prepared from peripheral blood leukocytes of a patient with acute lymphocytic leukemia.
|
3500230 |
1987 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
This study investigated the time course of TB4 and VEGF during AMI, cardiac arrest, and resuscitation.
|
21332365 |
2011 |
|
Adenocarcinoma of colon
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thymosin β4 was highly expressed in the hepatic cells in the normal adult liver, duct, and acinar cells in pancreas, and muscle cells in the heart and also expressed highly in certain tumor cells, including osteosarcoma, colon adenocarcinoma, esophageal squamous cell carcinoma, kidney and urinary bladder transitional carcinoma, lung cancer, and liver cancer.
|
20975530 |
2011 |
|
Adenoviral infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Together, our results show for the first time that in vivo silencing of Tβ4 expression by its shRNA generated after adenoviral infection can suppress CRC growth.
|
25124811 |
2014 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thymosin β 4 gene silencing decreases stemness and invasiveness in glioblastoma.
|
24355709 |
2014 |
|
Adult Liver Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Thymosin β4 was highly expressed in the hepatic cells in the normal adult liver, duct, and acinar cells in pancreas, and muscle cells in the heart and also expressed highly in certain tumor cells, including osteosarcoma, colon adenocarcinoma, esophageal squamous cell carcinoma, kidney and urinary bladder transitional carcinoma, lung cancer, and liver cancer.
|
20975530 |
2011 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Among leukemic cell samples obtained from leukemia patients, the T beta 4 gene was highly expressed in a lymphoid lineage, especially in adult T-cell leukemia (ATL) cells, rather than in a granulocyte lineage.
|
2393720 |
1990 |
|
Allergic Conjunctivitis
|
0.010 |
AlteredExpression
|
disease |
LHGDN |
Conjunctival expression of thymosin-beta4 in vernal keratoconjunctivitis.
|
17200658 |
2006 |
|
AMYOTROPHIC LATERAL SCLEROSIS 1
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Amyotrophic Lateral Sclerosis, Familial
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Amyotrophic Lateral Sclerosis, Sporadic
|
0.300 |
Biomarker
|
disease |
CTD_human |
Differential expression of inflammation- and apoptosis-related genes in spinal cords of a mutant SOD1 transgenic mouse model of familial amyotrophic lateral sclerosis.
|
11796754 |
2002 |
|
Aortic Aneurysm, Abdominal
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thymosin beta-4 was the most abundant of 101 transcripts detected in both AAAs and normal aorta, whereas 44 genes exhibited differential patterns of expression (39 predominant in AAAs and 5 in normal aorta).
|
11436088 |
2001 |
|
Autoimmune thyroid disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results implicate a coordinate expression of ICAM-1, T beta 4 and Ii in autoimmune thyroid disease, yielding distinct cellular expression patterns.
|
7524954 |
1994 |
|
B-Cell Lymphomas
|
0.010 |
Biomarker
|
group |
BEFREE |
In conclusion, inhibition of microRNA-34a mediated protection of thymosin beta 4 in endothelial progenitor cells against advanced glycation endproducts by targeting B-cell lymphoma 2, which was helpful for understanding the therapeutic potential of thymosin beta 4 for diabetic patients.
|
31397599 |
2019 |
|
Bacterial keratitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Use of adjunctive Tβ4 provides a more efficacious approach for bacterial keratitis by addressing both the infectious pathogen and deleterious host response.
|
30241380 |
2018 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that the expression of thymosin β4 is highly related with tumorigenesis of certain tumors including the osteosarcoma and colorectal cancers.
|
20975530 |
2011 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
These results suggest that Tβ4 levels are related to tumorigenesis in ovarian cancers and metastasis in stomach cancers.
|
23055022 |
2013 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Thymosin beta-4 (Tβ4) is known to be involved in tumorigenesis.
|
25124811 |
2014 |
|
Carcinogenesis
|
0.080 |
AlteredExpression
|
phenotype |
BEFREE |
Taken together, these results suggest that Tβ4 overexpression could be one of the causes of tumorigenesis and progression in OSCCs.
|
26276576 |
2016 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
In this review, we summarize the staging system, the most critical genetic and epigenetic alterations, the pleiotropic effects of MMP-7, the controversial roles of Hedgehog signaling, the intriguing involvement of thymosin beta-4, and the possible contribution of the putative colon (cancer) stem cells in CRC tumorigenesis.
|
16501890 |
2006 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Recently, a role for Tβ(4) has been proposed in experimental and human carcinogenesis.
|
22233609 |
2012 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Thymosin beta-4 (Tβ4) is known as a major pleiotropic actin-sequestering protein that is involved in tumorigenesis.
|
31333080 |
2019 |
|
Carcinogenesis
|
0.080 |
Biomarker
|
phenotype |
BEFREE |
Thymosin beta 4 (Tβ4), a pleiotropic actin-sequestering polypeptide that is involved in wound healing and developmental processes, has been reported to be strongly associated with tumorigenesis.
|
27521796 |
2016 |
|
Carcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Recent studies have shown that overexpression of the Tbeta-4 gene occurs not only in many human carcinomas but also in the highly metastatic melanomas and fibrosarcomas.
|
12761500 |
2003 |