|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Since TNF-alpha acts via two membrane receptors, we have extended those studies to investigate the distribution of the p55 and p75 TNF receptors (TNF-R) in RA tissue.
|
1320571 |
1992 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In summary, the ability of IL-1 and TNF to preferentially induce stromelysin and collagenase expression, versus TIMP, may define a pivotal role for these cytokines in the pathogenesis of rheumatoid arthritis.
|
1698773 |
1990 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Elevated levels of a number of cytokines such as Il-1, IL-2, IL-6, interferon-gamma (IFN-gamma), transforming growth factor-beta and tumour necrosis factor-alpha (TNF-alpha) have been detected in the synovial fluid of patients with rheumatoid arthritis and other inflammatory arthritides.
|
1914237 |
1991 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Using neutralizing antibodies to tumor necrosis factor (TNF)-alpha we demonstrated that GM-CSF production in RA synovial cell cultures is dependent on the continued presence of active TNF-alpha.
|
1915559 |
1991 |
|
Rheumatoid Arthritis
|
0.700 |
Therapeutic
|
disease |
CTD_human |
Tumor necrosis factor alpha (TNF) and interleukin-1 (IL-1) production by alveolar macrophages (AM) was evaluated in 17 rheumatoid arthritis (RA) patients without interstitial lung disease (ILD, Group 1) and 14 RA patients with clinical ILD (Group 2) in comparison with 10 control subjects.
|
2001072 |
1991 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
CTD_human |
Tumor necrosis factor alpha (TNF) and interleukin-1 (IL-1) production by alveolar macrophages (AM) was evaluated in 17 rheumatoid arthritis (RA) patients without interstitial lung disease (ILD, Group 1) and 14 RA patients with clinical ILD (Group 2) in comparison with 10 control subjects.
|
2001072 |
1991 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Cytokines in chronic inflammatory arthritis. VI. Analysis of the synovial cells involved in granulocyte-macrophage colony-stimulating factor production and gene expression in rheumatoid arthritis and its regulation by IL-1 and tumor necrosis factor-alpha.
|
2026869 |
1991 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Tumour necrosis factor alpha (TNF alpha) was produced spontaneously at high levels by both RA and OA synovial cells.
|
2505790 |
1989 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We describe here an Nco I restriction fragment length polymorphism of tumor necrosis factor carried by the 8.1 (HLA-A1,B8,BfS,C4AQ0,C4B1,DR3) and the 44.1 (HLA-B44,BfS,C4A3,C4BQ0,DR4) ancestral haplotypes associated with complications of rheumatoid arthritis.
|
2573586 |
1989 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the uncommon allele (TNF2) of a polymorphism in the promoter region of the tumour necrosis factor alpha (TNF alpha) gene in patients with rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) was found to be 3 times that of the normal anglo-saxon population.
|
7614782 |
1995 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
In addition, type I collagen could also induce IL-1, IL-6 and TNF-alpha in these samples from RA and OD patients but was less potent than type II collagen.
|
7622181 |
1995 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A tumour necrosis factor alpha polymorphism is not associated with rheumatoid arthritis.
|
7668906 |
1995 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recent studies show that important mediators in the pathogenesis of RA such as prostaglandin E, interleukin 1 (IL1) or tumor necrosis factor (TNF) alpha also play important roles in bone remodelling.
|
7809909 |
1994 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We found evidence that the IL-10 expression was functionally relevant, as neutralization of endogenously produced IL-10 in the RA synovial membrane cultures resulted in a two- to threefold increase in the protein levels of proinflammatory cytokines tumor necrosis factor alpha (TNF-alpha) and IL-1 beta, although IL-6 and IL-8 levels were not affected.
|
8163935 |
1994 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
To investigate both the involvement of chemokines in general and the relative importance of specific chemokines in rheumatoid arthritis (RA), we characterized the effect of the monokines tumor necrosis factor alpha (TNF alpha) and interleukin-1 beta (IL-1 beta) on the synthesis of neutrophil-activating factors by synovial fibroblasts isolated from the joints of patients with RA.
|
8216423 |
1993 |
|
Rheumatoid Arthritis
|
0.700 |
Therapeutic
|
disease |
CTD_human |
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
|
8391952 |
1993 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
CTD_human |
TNF-alpha in rheumatoid arthritis and prospects of anti-TNF therapy.
|
8391952 |
1993 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Expression of monocyte chemotactic and activating factor in rheumatoid arthritis. Regulation of its production in synovial cells by interleukin-1 and tumor necrosis factor.
|
8507217 |
1993 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Differentially regulated tumor necrosis factor (TNF) expression may lead to a better understanding of the causal pathogenesis of EOPA while T cell receptor (TCR) gene polymorphisms appear crucial for RA manifestations in certain patient groups.
|
8582358 |
1995 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Therefore, our data do not suggest a role for transcriptionally distinct TNFA alleles in the susceptibility to RA.
|
8641702 |
1996 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
TNF microsatellites found to be associated with RA do not appear to be independent of class II HLA associations.
|
8670318 |
1996 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The TNF-LT region appears to influence susceptibility to RA, distinct from HLA-DR.
|
8751869 |
1996 |
|
Rheumatoid Arthritis
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
TNF microsatellite polymorphisms are different in male and female patients with RA.
|
9002044 |
1997 |
|
Rheumatoid Arthritis
|
0.700 |
Biomarker
|
disease |
BEFREE |
The results of this study suggests that the TNF alpha gene may play a role in the disease profile of rheumatoid arthritis.
|
9027971 |
1997 |
|
Rheumatoid Arthritis
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
To compare the cytokine profile with the degree and composition of cellular infiltration in rheumatoid arthritis (RA) and osteoarthritis (OA) synovium, synovial membranes from patients with RA (n = 14) and OA (n = 5) were examined, employing immunohistochemistry and competitive reverse-transcriptase polymerase chain reaction (RT-PCR), for interleukin (IL)-I beta, IL-2, IL-4, IL-5, IL-6, and IL-10, and tumour necrosis factor-alpha (TNF-alpha) gene expression.
|
9032818 |
1997 |