Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor alpha (TNF alpha) antagonists are biologic agents used in the management of inflammatory conditions such as rheumatoid arthritis, seronegative spondyloarthropathies and inflammatory bowel disease.
|
27748629 |
2017 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Recent advances show that proinflammatory mediators in Paneth cell dense core secretory granules mediate tumor necrosis factor-α-induced shock, that Paneth cell α-defensins modulate the composition of the small intestinal microflora, that development of crypt organoid culture systems provides a novel means for investigating the crypt microenvironment, and that varied genetic defects that disrupt Paneth cell homeostasis are emergent as risk factors in inflammatory bowel disease.
|
20693892 |
2010 |
Inflammatory Bowel Diseases
|
0.600 |
AlteredExpression
|
group |
BEFREE |
To determine the effect of CAR in IBD using QPCR and Western blotting to determine the expression of CAD in TNF-<i>α</i> induced NCM460 and SW480 cells and IBD tissues compared to control groups.
|
30175139 |
2018 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Although these data are observational, they have implications for the use of TNF-α inhibitors in patients with inflammatory bowel disease and other immunodysregulatory disorders.
|
28038706 |
2017 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
The aim of this study was to describe the surgical stress response in patients with inflammatory bowel disease (IBD) and to investigate whether the pre-operative administration of anti-tumor necrosis factor alpha (anti-TNF-α) agents modify the surgical stress response.
|
30390672 |
2018 |
Inflammatory Bowel Diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
The genes encoding for tumor necrosis factor-alpha (TNF-alpha), epidermal growth factor receptor (EGFR) and the vitamin D receptor (VDR) are colocalized to inflammatory bowel disease-associated linkage regions on chromosomes 6, 7 and 12.
|
12428072 |
2002 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
The efficacy of antitumour necrosis factor (TNF)-α biologics has validated the role of inflammatory cytokines notably TNF-α in the exacerbation and perpetuation of IBD.
|
30407662 |
2019 |
Inflammatory Bowel Diseases
|
0.600 |
GeneticVariation
|
group |
BEFREE |
Additionally, polymorphisms of TNF-α gene are known to affect the gene expression level and particular TNF-α genotypes may influence the response of IBD patients treated with TNF-α inhibitors.
|
25386052 |
2014 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Antibodies against tumor necrosis factor represent an effective therapy for patients with inflammatory bowel disease.
|
23448791 |
2013 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
In inflammatory bowel disease (IBD), immune activation with increased circulating TNF-α is linked to the intensity of gastrointestinal symptoms and depression or anxiety.
|
29518097 |
2018 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Opposite effects of interferon regulatory factor 1 and osteopontin on the apoptosis of epithelial cells induced by TNF-α in inflammatory bowel disease.
|
25208103 |
2014 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Since anti-tumor necrosis factor (TNF)-α agents (TNF-α inhibitors) induce both clinical response and remission in patients with moderate to severe inflammatory bowel disease (IBD), the use of anti-TNF therapies has fundamentally changed the approach to treatment for patients with IBD.
|
30286108 |
2018 |
Inflammatory Bowel Diseases
|
0.600 |
AlteredExpression
|
group |
BEFREE |
TNF receptor (TNFR) 2 expression is increased in inflammatory bowel diseases, the azoxymethane/dextran sodium sulfate (AOM/DSS) model of colitis-associated cancer, and by combined interleukin (IL) 6 and TNFα.
|
21994466 |
2011 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
There was a positive correlation between IgA and IgG on CD but not UC, as well as between IgA and TNF in total IBD patients.
|
30884988 |
2019 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Is There a Risk of Lymphoma Associated With Anti-tumor Necrosis Factor Drugs in Patients With Inflammatory Bowel Disease? A Systematic Review of Observational Studies.
|
30941038 |
2019 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Little is known about the risk of serious infection when combining anti-tumour necrosis factor [TNF] therapy for refractory inflammatory bowel disease [IBD] with immunosuppression after liver transplantation [LT].
|
28482085 |
2017 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
In recent years, more molecules, both biologically and chemically synthetized, have been developed as potential therapeutic options for IBD that target different molecular pathways aside from TNF blockade, and which have been proposed as targets for novel drugs.
|
31316377 |
2019 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
In inflammatory bowel disease (IBD), tumor necrosis factor plays an important role in mediating inflammation, but several other pathways are also involved in eliciting an inflammatory response.
|
29740202 |
2018 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
In addition, research into nuclear factor kappa B (NF-kappa B), the proteasome, interleukins, and tumor necrosis factor alpha has improved our understanding of IBD.
|
12710125 |
2003 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Anti-tumor necrosis factor-alpha (anti-TNF-α) therapy alters the gut microbiota in many diseases, including inflammatory bowel disease.
|
31556231 |
2019 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
We therefore performed a comprehensive analysis of vedolizumab-induced alterations in mucosal and systemic immunity in patients with inflammatory bowel disease (IBD), using anti-inflammatory therapy with the TNFα antibody infliximab as control.
|
29730603 |
2019 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Clinical data including lifestyle and treatment response and biological specimens (blood, faeces, urine, and, in IBD patients, intestinal biopsies) are sampled prior to and while on TNF inhibitor therapy.
|
28505128 |
2017 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor antagonists have revolutionized the therapeutic management of inflammatory bowel disease.
|
28472597 |
2017 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) may be involved in the pathogenesis of inflammatory bowel disease.
|
28040992 |
2017 |
Inflammatory Bowel Diseases
|
0.600 |
Biomarker
|
group |
BEFREE |
Therapeutic Drug Monitoring During Induction of Anti-Tumor Necrosis Factor Therapy in Inflammatory Bowel Disease: Defining a Therapeutic Drug Window.
|
28816757 |
2017 |