TNNI3, troponin I3, cardiac type, 7137

N. diseases: 159; N. variants: 50
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018213
Disease: Graves Disease
Graves Disease
0.010 Biomarker disease BEFREE This case demonstrates the importance of ECG and cTnI screening among GD patients. 30503299 2020
CUI: C0085612
Disease: Ventricular arrhythmia
Ventricular arrhythmia
0.010 AlteredExpression disease BEFREE The high dose prolonged the repolarization period, induced hemorrhagic tendency, and increased plasma cardiac troponin I level in addition to enhancement of the changes observed after the low dose, whereas it neither affected the cardiac conduction nor induced ventricular arrhythmias. 31280457 2020
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis
0.010 Biomarker disease BEFREE We identified patients in the Atherosclerosis Risk in Communities Surveillance Study admitted with chest pain and an initially elevated cardiac troponin I, who presented within 12 hours of symptom onset and were classified with non-ST-segment elevation myocardial infarction. 30958029 2019
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis
0.010 Biomarker disease BEFREE We identified patients in the Atherosclerosis Risk in Communities Surveillance Study admitted with chest pain and an initially elevated cardiac troponin I, who presented within 12 hours of symptom onset and were classified with non-ST-segment elevation myocardial infarction. 30958029 2019
CUI: C0010278
Disease: Craniosynostosis
Craniosynostosis
0.010 Biomarker disease BEFREE Herein, we introduce a novel surface-enhanced Raman scattering (SERS)-based sandwich immunoassay platform to simultaneously detect cardiac troponin I (cTnI), N-terminal prohormone of brain natriuretic peptide (NT-ProBNP), and neutrophil gelatinase-associated lipocalin (NGAL) for the early diagnosis of CRS by using Raman reporter-molecule-labeled Ag-Au nanostars (Ag-Au NSs) as nanotags and a three-dimensional ordered macroporous (3DOM) Au-Ag-Au plasmonic array as substrate. 30499654 2019
CUI: C0021400
Disease: Influenza
Influenza
0.010 Biomarker disease BEFREE We applied this method to detect the influenza nucleoprotein (NP) and cardiac troponin I (cTnI). 31269392 2019
CUI: C0026837
Disease: Muscle Rigidity
Muscle Rigidity
0.010 Biomarker phenotype BEFREE In the presence of cardiac troponin I (cTnI), the aptamer resides from the electrode surface owing to its rigidity, resulting in a reduction in charge transfer resistance of the modified working electrode and a ratio enhancement of two ECL signals of nGO@TiO<sub>2</sub> NLPs. 31480838 2019
CUI: C0031039
Disease: Pericardial effusion
Pericardial effusion
0.010 AlteredExpression disease BEFREE TNNI3 expression in blood, and MMP9 expression in pericardial fluid, were significantly higher when the cause of death was mechanical asphyxia, probably because of the more sensitive response of these proteins to acute systemic hypoxia/ischemia. 31419595 2019
CUI: C0032285
Disease: Pneumonia
Pneumonia
0.010 Biomarker disease BEFREE A small-molecule compound, Robert Costa Memorial drug-1 (RCM-1), has been recently identified from high-throughput screen as an inhibitor of FOXM1 <i>in vitro</i> and in mouse model of allergen-mediated lung inflammation. 31040162 2019
Systemic Inflammatory Response Syndrome
0.010 AlteredExpression disease BEFREE RESULTS The plasma BNP and cTnI levels in pediatric patients with sepsis were significantly higher than those in the SIRS group (p<0.05). 30956276 2019
CUI: C0268318
Disease: Cholestasis of pregnancy
Cholestasis of pregnancy
0.010 AlteredExpression disease BEFREE Objective The objective of our study was to determine if a correlation exists between maternal total bile acid levels, degree of maternal pruritus, and fetal cardiac troponin-I levels in asymptomatic patients without a diagnosis of intrahepatic cholestasis of pregnancy. 31667041 2019
Left ventricular outflow tract obstruction
0.010 Biomarker disease BEFREE We sought to explore the associations between the presence of AF and circulating biomarkers reflecting cardiovascular function (N-terminal pro-brain natriuretic peptide, NT-pro BNP), endothelial function (big endothelin-1, big ET-1), inflammation (high-sensitivity C-reactive protein), and myocardial damage (cardiac troponin I, cTnI) in HCM patients with and without left ventricular outflow tract obstruction (LVOTO).In all, 375 consecutive HCM in-hospital patients were divided into an AF group (n = 90) and a sinus rhythm (SR) group (n = 285) according to their medical history and electrocardiogram results.In comparison with the SR group, peripheral concentrations of big ET-1, NT-pro BNP, and cTnI were significantly higher in patients with AF. 30626765 2019
CUI: C0852036
Disease: Pregnancy associated hypertension
Pregnancy associated hypertension
0.010 GeneticVariation phenotype BEFREE In multivariate analysis, PIH (OR: 18.71, P = 0.003), placental abnormality (OR: 26.78, P = 0.007), and decreased hemoglobin after delivery (OR: 2.59, P <0.001) were the factors associated with elevated cTnI. 30730993 2019
Non ST segment elevation myocardial infarction
0.010 Biomarker disease BEFREE We identified patients in the Atherosclerosis Risk in Communities Surveillance Study admitted with chest pain and an initially elevated cardiac troponin I, who presented within 12 hours of symptom onset and were classified with non-ST-segment elevation myocardial infarction. 30958029 2019
CUI: C1561643
Disease: Chronic Kidney Diseases
Chronic Kidney Diseases
0.010 Biomarker group BEFREE Commonly, cardiac troponin T (CTnT), cardiac troponin I (CTnI) or creatine kinase muscle/brain subtype (CK-MB) have been used as cardiac biomarkers to assess ACS with certain limitations, such as increased time to rise for diagnosis and increased levels in the patients with chronic kidney disease (CKD). 31772848 2019
CUI: C1608389
Disease: Autoimmune myocarditis
Autoimmune myocarditis
0.010 Biomarker disease BEFREE Animals immunized with cTnI developed autoimmune myocarditis with a significant deterioration of cardiac parameters compared to the corresponding control group. 30716658 2019
CUI: C1719672
Disease: Severe Sepsis
Severe Sepsis
0.010 Biomarker disease BEFREE In this study, none of LVSD, cTnI, and NT-proBNP was associated with the prognosis of pediatric severe sepsis. 30921240 2019
CUI: C1739395
Disease: Takotsubo Cardiomyopathy
Takotsubo Cardiomyopathy
0.010 Biomarker disease BEFREE Our aim was to investigate whether strain values by STE and cardiac troponin I (cTnI) could predict early myocardial injury in rats with SCM. 31765453 2019
Idiopathic pulmonary arterial hypertension
0.010 Biomarker disease BEFREE Brain natriuretic peptide (BNP) and cardiac troponin I (cTnI) were measured simultaneously in 151 consecutive patients with no history of heart disease or pulmonary arterial hypertension (PAH). 30068764 2019
CUI: C3266262
Disease: Multiple Chronic Conditions
Multiple Chronic Conditions
0.010 Biomarker disease BEFREE Advancements in health care monitoring demand a rapid, accurate and reliable early diagnosis of "Heart Attack" (acute myocardial infarction) with an objective to develop a cost-effective, rapid and label-free point of care diagnostic test kit for the detection of cardiac troponin I (cTnI) on paper-based multi-frequency impedimetric transducers. 31844990 2019
CUI: C0002170
Disease: Alopecia
Alopecia
0.010 AlteredExpression disease BEFREE Alopecia areata plasma samples with high cardiac troponin I levels also induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays. 29740659 2018
CUI: C0002171
Disease: Alopecia Areata
Alopecia Areata
0.010 AlteredExpression disease BEFREE Alopecia areata plasma samples with high cardiac troponin I levels also induced significantly higher rates of cardiomyocyte apoptosis in cell culture assays. 29740659 2018
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis
0.010 Biomarker disease BEFREE High-sensitivity cardiac troponin I is a biomarker for occult coronary plaque burden and cardiovascular events in patients with rheumatoid arthritis. 29554376 2018
CUI: C0018553
Disease: Hamartoma Syndrome, Multiple
Hamartoma Syndrome, Multiple
0.010 Biomarker disease BEFREE Furthermore, in the Cox proportional hazard analysis, cTnI, but not ACE, IL2R or BNP, was a predictor of fatal arrhythmia in sarcoidosis patients (HR 2.418, P = 0.003).Higher ACE and sIL2-R are associated with systemic lesions, whereas BNP is a useful marker for detecting cardiac involvement in sarcoidosis patients. cTnI is a predictor of fatal arrhythmia in CS patients. 30101857 2018
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease
0.010 Biomarker disease BEFREE This study evaluated the association between high-sensitivity cardiac troponin I concentration and cardiovascular events in patients with COPD and heightened cardiovascular risk. 30165984 2018