|
Chronic Obstructive Airway Disease
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations.
|
30804561 |
2019 |
|
Autism Spectrum Disorders
|
0.100 |
GeneticVariation
|
disease |
CLINVAR |
|
|
|
|
Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
There was a statistically significant increase in the TOP2B H-index in locally advanced CaP in comparison with localized tumors (p=0.046).
|
24195515 |
2014 |
|
Leukemia, Myelocytic, Acute
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
NUP98 is fused to topoisomerase (DNA) IIbeta 180 kDa (TOP2B) in a patient with acute myeloid leukemia with a new t(3;11)(p24;p15).
|
16166424 |
2005 |
|
Congestive heart failure
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, cardiomyocyte-specific deletion of Top2b protects mice from the development of doxorubicin-induced progressive heart failure, suggesting that doxorubicin-induced cardiotoxicity is mediated by topoisomerase-IIβ in cardiomyocytes.
|
23104132 |
2012 |
|
Congenital Abnormality
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Top2b deletion leads to malformation of photoreceptor outer segments (OSs) and synapses accompanied by dramatic cell loss at late-stage photoreceptor differentiation.
|
28370415 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.
|
23277395 |
2013 |
|
Malignant neoplasm of endometrium
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Topoisomerase IIβ binding protein 1 c.*229C>T (rs115160714) gene polymorphism and endometrial cancer risk.
|
24346708 |
2014 |
|
Heart failure
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, cardiomyocyte-specific deletion of Top2b protects mice from the development of doxorubicin-induced progressive heart failure, suggesting that doxorubicin-induced cardiotoxicity is mediated by topoisomerase-IIβ in cardiomyocytes.
|
23104132 |
2012 |
|
Li-Fraumeni Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
While 11 genes (ATP-binding cassette, sub-family G (WHITE), member 2(ABCG2), activating transcription factor (ATF2), beta-2-microglobulin (B2M), deoxycytidine kinase (DCK), occludin (OCLN), v-raf-1 murine leukemia viral oncogene homolog (RAF1), ralA binding protein 1 (RALBP1), splicing factor (45 kD) (SPF45), S-phase kinase-associated protein 2 (p45) (SKP2), tumor protein p53 (Li-Fraumeni syndrome) (TP53) and topoisomerase (DNA) II beta (TOP2B)) maintained the unmethylated patterns, three genes displayed to various extents the hypermethylation state in tumor tissues in comparison with the normal counterparts.
|
15526362 |
2004 |
|
Deformity
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Top2b deletion leads to malformation of photoreceptor outer segments (OSs) and synapses accompanied by dramatic cell loss at late-stage photoreceptor differentiation.
|
28370415 |
2017 |
|
Endometrial Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Topoisomerase IIβ binding protein 1 c.*229C>T (rs115160714) gene polymorphism and endometrial cancer risk.
|
24346708 |
2014 |
|
Global developmental delay
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Global developmental delay and intellectual disability associated with a de novo TOP2B mutation.
|
28343847 |
2017 |
|
Breast Carcinoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer.
|
23277395 |
2013 |
|
Nonsyndromic Deafness
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Therefore, we hypothesized that mutations in TOP2B can cause autosomal-dominant nonsyndromic hearing impairment through inhibition of the PI3K-Akt signalling pathway.
|
31198993 |
2019 |
|
Intellectual Disability
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Global developmental delay and intellectual disability associated with a de novo TOP2B mutation.
|
28343847 |
2017 |
|
Prostatic Intraepithelial Neoplasias
|
0.300 |
Biomarker
|
disease |
CTD_human |
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
|
20601956 |
2010 |
|
Non-Small Cell Lung Carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
We used cell viability assays, western blotting, and EdU proliferation assay combined with calcein-AM treatment or siRNA interference to investigate the role of topoisomerase IIβ binding protein 1 (TopBP1) and p53 in NSCLC chemotherapy.
|
28628491 |
2017 |
|
Leukemia, Myelocytic, Acute
|
0.040 |
Biomarker
|
disease |
BEFREE |
For investigation of relative differences in mRNA expression levels and of correlations in the expression of genes possibly involved in multidrug resistance (MDR) of acute myelogenous leukemias (AML), a complementary DNA polymerase chain reaction (cDNA-PCR) analysis was established for the genes encoding MDR1/P-glycoprotein, the multidrug resistance-associated protein (MRP), topoisomerase II alpha, topoisomerase II beta, topoisomerase I, glutathione S-transferase pi, protein kinase C (PKC) isozymes alpha, beta 1, beta 2, epsilon, eta, theta and cyclin A.
|
8642857 |
1996 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
Here, we hypothesize that these transcription-induced, TOP2B-mediated DSBs can also be exploited therapeutically and propose that, in hormone-dependent tumors like breast and prostate cancers, a hormone-cycling therapy, in combination with topoisomerase II poisons or inhibitors of the DNA repair components PARP1 and DNA-PK, could overwhelm cancer cells with transcription-associated DSBs.
|
21385925 |
2011 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
The results indicate that detection of the TMPRSS2-ERG fusion gene and parallel immunohistochemical examination of AR, TOP2B and ERG has diagnostic significance and may be useful in assessing the biological character of the prostate cancer as well as selecting the best treatment.
|
24195515 |
2014 |
|
Malignant neoplasm of prostate
|
0.030 |
Biomarker
|
disease |
BEFREE |
Androgen-induced TOP2B-mediated double-strand breaks and prostate cancer gene rearrangements.
|
20601956 |
2010 |
|
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Topoisomerase IIβ-binding protein 1 (TOPBP1) participates in DNA replication and DNA damage response; however, its role in DNA repair and relevance for human cancer remain unclear.
|
26811421 |
2016 |
|
Congestive heart failure
|
0.020 |
Biomarker
|
disease |
BEFREE |
Besides the most common hypothesis that anthracycline-induced congestive heart failure (CHF) is mainly caused by generation of reactive oxygen species, recent data point to a critical role of topoisomerase II beta (TOP2B), which is a primary target of anthracycline poisoning, in the pathophysiology of CHF.
|
28102848 |
2017 |
|
Acute Promyelocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our results identify a novel mechanism of resistance in APL and provide further insight to the role of TopoIIbeta in gene regulation and differentiation.
|
18212063 |
2008 |