Small cell carcinoma of lung
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Small-cell lung cancer (SCLC) is an excellent candidate for early detection given there are no successful therapeutic options for late-stage disease, and it displays almost universal inactivation of TP53.
|
27377626 |
2016 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Small cell lung cancer TP53 mutations lead to expression of tumor antigens that elicits specific cytotoxic T-cell immune responses.
|
30591959 |
2019 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Small cell lung cancer (SCLC) tumor suppressors regulate the stem cells: Rb and p53 suppress self-renewal, whereas Notch marks the stem cells and initiates deprogramming and transit amplification.
|
31585080 |
2019 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Small-cell lung cancer has mutations or deletions in the p53 and retinoblastoma genes more frequently than are found in non-small-cell lung cancer.
|
9260589 |
1997 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
A p53 wild-type small cell lung cancer cell line (SBC3) and three p53 mutant cell lines (SBC5, small cell lung cancer; PC3, adenocarcinoma; and EBC1, squamous cell carcinoma) were infected with AxE1AdB, in which the E1B55K gene was deleted, to assess the cytotoxicity and induction of apoptosis.
|
16211279 |
2005 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A mouse model has been developed based on the fact that the RB and p53 tumor suppressor genes are mutated in more than 90% of human SCLCs.
|
20406986 |
2010 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Alterations targeting the tumor suppressor Pten occurred in the majority of murine SCLC studied, and engineered Pten deletion accelerated murine SCLC and abrogated loss of Chr19 in Trp53; Rb1; Pten compound mutant tumors.
|
24630729 |
2014 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
An SNP, Val83Met, in the MTH1 (microtT homolog 1) gene encoding a triphosphatase that hydrolyzes pro-mutagenic oxidized nucleoside triphosphates, such as 8-hydroxy-dGTP and 2-hydroxy-dATP, showed the strongest and a significant association with SCLC risk [odds ratio (OR)=1.6, 95% confidence interval (CI): 1.2-2.2, P=0.004], while three other SNPs in the TP53, BLM and SNM1 genes, respectively, also showed marginal associations (0.05<P<0.1).
|
16774934 |
2006 |
Small cell carcinoma of lung
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Chromosome abnormalities and p53 expression in a small cell carcinoma of the bladder.
|
7889499 |
1995 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Coincident abnormalities of K-ras and p53, or K-ras and RB genes were not found in any cell lines, and those of the p53 and RB genes were found in only 2 SCLC lines.
|
8263009 |
1994 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Comprehensive analysis of differential expression profiles reveals potential biomarkers associated with the cell cycle and regulated by p53 in human small cell lung cancer.
|
29545845 |
2018 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
CTD_human |
Comprehensive genomic analysis identifies SOX2 as a frequently amplified gene in small-cell lung cancer.
|
22941189 |
2012 |
Small cell carcinoma of lung
|
0.700 |
SomaticCausalMutation
|
disease |
ORPHANET |
Comprehensive genomic profiles of small cell lung cancer.
|
26168399 |
2015 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Conclusion EGFR TKI-resistant SCLCs are branched out early from the LADC clones that harbor completely inactivated RB1 and TP53.
|
28498782 |
2017 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Cytogenetic losses of 5q21, 13q14, and 17p13 (sites of the APC, RB1, and TP53 suppressor loci, respectively) also are common in SCLC.
|
8402711 |
1993 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Data were insufficient to determine the prognostic value of p53 in small cell lung cancer.
|
11716177 |
2001 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Deletions of the 3p chromosome region and molecular alterations of the tumor suppressor genes RB1 and TP53, located, respectively, at 13q14 and 17p13, are well-documented in small cell lung cancer (SCLC).
|
1346589 |
1992 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Despite the fact that many of the genetic alterations, including loss of heterozygocity in the 3p chromosome locus and point mutations in the tumor-suppressor genes TP53 and retinoblastoma (RB1), occur in nearly all histopathologic types of lung cancer, the frequency and the "timing" of their occurrence seems to differ between small-cell lung cancer (SCLC) cells, that are characterized by neuroendocrine differentiation, and non-small-cell lung cancer (NSCLC) cells.
|
19914087 |
2010 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Direct sequencing of DNA isolated from the small cell carcinoma revealed a TGC to TTC mutation at codon 404 of TP53 exon 5.
|
21989450 |
2012 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Dysregulation of tumor suppressor genes TP53 and RB1 was observed in 82% and 62% of SCLC patients, respectively, and more than half of the SCLC patients (62%) harbored TP53 and RB1 mutation and/or copy number loss.
|
27093186 |
2016 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Epidemiological studies indicate the majority of SCLCs to be caused by smoking and the TP53 mutational pattern to be consistent with that evoked by smoke carcinogens; however, there is no direct evidence that such carcinogens induce alterations to RB in SCLC.
|
19390995 |
2009 |
Small cell carcinoma of lung
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice.
|
22941188 |
2012 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
CTD_human |
Finally, we detected many of the alterations found in humans in SCLC tumors from Tp53 and Rb1 double knockout mice.
|
22941188 |
2012 |
Small cell carcinoma of lung
|
0.700 |
Biomarker
|
disease |
BEFREE |
Five xenografts came from untreated patients (SCLC-61, SCLC-6, SCLC-10, SCLC-41, and SCLC-96) and three after treatment (SCLC-74, SCLC-101, and SCLC-108). p53 was inactivated in all of them.
|
10815935 |
2000 |
Small cell carcinoma of lung
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
Frequent inactivation of TP53 and RB1 as well as histone dysmodifications in SCLC suggest that transcriptional and epigenetic regulations play a major role in SCLC disease evolution.
|
29760044 |
2018 |