|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Combinatory anti-tumor effects of electroporation-mediated chemotherapy and wild-type p53 gene transfer to human esophageal cancer cells.
|
11251180 |
2001 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
We investigated associations of p53 overexpression with codon 72 variants and other factors with esophageal cancer.
|
16318864 |
2006 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In order to characterize p53 alterations in esophageal cancer and to study their roles in carcinogenesis, we performed gene mutation and immunohistochemical analysis on 43 surgically resected human esophageal specimens, which contain squamous cell carcinoma (SCC) and adjacent non-cancerous lesions, from a high-incidence area of Linzhou in Henan, China.
|
10223186 |
1999 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Loss of RAR-beta expression and accumulation of p53 and Ki 67 proteins may serve as biomarkers for esophageal cancer.
|
11315258 |
2001 |
|
Malignant neoplasm of esophagus
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
These data indicate that inactivation of the p53 gene is a frequent event in oesophageal squamous cell carcinomas and such an inactivation might be an important molecular pathway for the development of oesophageal cancer.
|
8054284 |
1994 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Our findings do not support the association between risk of oesophageal cancer, human papilloma virus infection, and TP53 codon 72 polymorphism in a Chinese population at high risk of oesophageal cancer.
|
11146230 |
2001 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Concomitant presence of mutations in mitochondrial genome and p53 in cancer development - a study in north Indian sporadic breast and esophageal cancer patients.
|
18792899 |
2008 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
A normal esophageal epithelial cell line (EN53F) and two human esophageal cancer cell lines (ECGI-10 and T.Tn) with a p53 alteration were used.
|
11495154 |
2001 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The codon 213 P53 mutation that recurred in proximal CRC was previously reported as frequent in esophageal cancer from Northern Iran.
|
18330889 |
2008 |
|
Malignant neoplasm of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Frequent aberrant p53 and Fhit expression in endoscopically resected superficial hypopharyngeal cancer and esophageal cancer.
|
28693209 |
2017 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
There are no data on p53 mutations in esophageal cancer patients from Iran yet; however, this country experiences one of the highest cancer mortality rates in the world for esophageal squamous cell carcinomas (ESCCs).
|
11306496 |
2001 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
South African patients with oesophageal squamous cell carcinoma display a lower incidence of point mutations in the p53 gene than described elsewhere, suggesting that the profile of aetiological agents may be different than described for other high-risk areas for oesophageal cancer.
|
12121007 |
2003 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Viral shedding after p53 adenoviral gene therapy in 10 cases of esophageal cancer.
|
20175784 |
2010 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms and mutations found in the regions flanking exons 5 to 8 of the TP53 gene in a population at high risk for esophageal cancer in South Africa.
|
12550754 |
2003 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In summary, p73 G4C14-to-A4T14 polymorphism but not the p53 intron3 16 bp duplication polymorphism is associated with EC and its clinical characteristics in northern Indian population.
|
21573788 |
2012 |
|
Malignant neoplasm of esophagus
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The sensitivity of the p53 fluorescent in situ hybridization probe was13.3 % for any abnormality, 10 % for intestinal metaplasia, and 0 % for dysplasia or esophageal cancer.
|
27561634 |
2017 |
|
Malignant neoplasm of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
We also observed a significant increase in ERCC1 expression, and decrease in p53 and EGFR expression, in EC-9706 cells treated with SNX-2112 (P < 0.05), indicating the regulation of EC by SNX-2112.
|
27420968 |
2016 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
CTD_human |
Low expression of Bax predicts poor prognosis in patients with locally advanced esophageal cancer treated with definitive chemoradiotherapy.
|
17634542 |
2007 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
We have examined how disease progression correlates with changes in expression of the p14ARF (ARF) tumour suppressor, a key regulator of the p53 tumour suppressor pathway that is silenced in some 30% of cancers overall, but for which a role in oesophageal cancer is unclear.
|
18410530 |
2009 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
These observations further implicate the p53 tumor suppressor gene in the pathogenesis of human esophageal cancers.
|
8007679 |
1994 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
Esophageal cancer (ESC) is one of the most deadly diseases for human. p53 in most cancers, including ESC cell, is mutated, and the mutated p53 losses its original function and acquires "gain of function" that allows for promoting the hallmarks of cancer, such as antiapoptosis, metastasis, invasion, angiogenesis, and resistance to chemotherapy.
|
31354907 |
2019 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
To test the value of TP53 as a biomarker prognosing outcome in patients with neoadjuvantly treated esophageal cancer.
|
25135238 |
2014 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
However, the finding of p53 mutations in Barrett's epithelium adjacent to adenocarcinomas may have clinical implications for p53 as a premalignant marker for esophageal cancer.
|
1943188 |
1991 |
|
Malignant neoplasm of esophagus
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Inactivated tumor suppressor genes, including p53, often are suggested by loss of heterozygosity (LOH) studies. p53 gene inactivation has been reported in esophageal cancers.
|
8443743 |
1993 |
|
Malignant neoplasm of esophagus
|
0.700 |
Biomarker
|
disease |
BEFREE |
The goal was to compare the cellular events, p53 protein accumulation and gene mutations with the presence of serum anti-p53 antibodies (p53-Abs) and to assess the utility of serological p53-Ab analysis as a surrogate marker for p53 alterations in esophageal cancer.
|
10709097 |
2000 |