|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
We examined 33 patients with renal cell carcinoma and 29 with bladder cancer; heterozygosity in the p53 gene was lost in 60% (6 of 10 cases) and 73% (8 of 11 cases) of the renal and bladder tumors, respectively.
|
2009130 |
1991 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The p53 mutations are the first genetic alterations demonstrated to occur in a high proportion of primary invasive bladder cancers.
|
2024123 |
1991 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
[Science (Washington DC), 252: 706-709, 1991] showing that p53 gene mutations were frequently found in invasive bladder cancers by sequence analysis on polymerase chain reaction amplified products corresponding to exons 5 to 9.
|
1540947 |
1992 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Inactivation of two well-characterized tumor suppressor genes, p53 and Rb, also appears to be important in the pathogenesis of bladder cancer, and evidence suggests that inactivation of p53 correlates with the acquisition by bladder cancer cells of the invasive phenotype.
|
1556051 |
1992 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The results confirm that p53 is involved in the growth regulation of bladder cancer and is certainly a subject for detailed analysis of specific mutations.
|
8428790 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Analysis of multiple or recurrent primary tumors in 7 patients for these markers was generally consistent with recently published data that the tumors are monoclonal in origin and that p53 mutations occur as a late event in the generation of invasive bladder cancers.
|
8358736 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To elucidate the impact of cigarette smoking or bilharzial infection on the p53 gene mutation pattern, 61 cases of urothelial cancer from Japan and 7 cases of bladder cancer with schistosomiasis from Egypt were examined for mutations of the p53 gene.
|
8339293 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Recent reports reveal that mutations of the p53 tumor suppressor gene (also known as TP53) occur commonly in bladder cancers.
|
7677935 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Finally, both grade and stage of bladder cancer are related to p53 alterations, detected by immunohistochemistry or molecular methods.(ABSTRACT TRUNCATED AT 400 WORDS)
|
7901994 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
Since mutation and allelic loss of the p53 gene were also detected in a low-grade and low-stage tumor in the present study, it is suggested that the p53 gene is involved in early stages of some bladder cancers as well as in their late stages.
|
8123944 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
Additional follow-up and further studies are required to better define the role of p53 nuclear overexpression and 17p deletions as markers of tumor progression in human bladder cancer.
|
7904525 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Distinct pattern of p53 mutations in bladder cancer: relationship to tobacco usage.
|
8439962 |
1993 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We undertook the present study in order to determine the frequency of MDM2 and TP53 abnormalities in bladder tumors, as well as to examine the clinical relevance of identifying their altered patterns of expression in patients affected with bladder cancer.
|
8064890 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
To obtain further information on a possible involvement of p53 in bladder cancer development or tumor progression, investigations of precursor lesions and early stages of this disease are required.
|
8087143 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Physical deletion of the p53 gene in bladder cancer. Detection by fluorescence in situ hybridization.
|
8160775 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Therefore we studied p53 mutations in 47 bladder cancers obtained from 45 patients using polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis.
|
8080737 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
To demonstrate the program, the mutational spectra of single base substitutions in the p53 gene are compared in (i) bladder cancers from smokers and non-smokers, (ii) small-cell lung cancers, non-small-cell lung cancers and colon cancers and (iii) hepatocellular carcinomas from high- and low-aflatoxin exposure groups. p53 mutations differ in several important aspects from a typical mutational spectra experiment, where a homogeneous population of cells is treated with a specific mutagen and mutations at a specific locus are recovered by phenotypic selection.
|
7955067 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The objective of this study was to characterize the pattern of p53 mutations in bladder cancer.
|
7906253 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The detection of nuclear p53 was significantly associated with an increased risk of recurrence of bladder cancer (P < 0.001) and with decreased overall survival (P < 0.001).
|
7935683 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Our results are consistent with the literature in that mutations in p53 are predominantly found in high grade bladder cancer (Odds Ratio = 4.05, Fisher Exact P = 0.104); however, the results were not statistically significant due to small numbers.
|
7957118 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
mRNA and protein expression of p53 mutations in human bladder cancer cell lines.
|
8033064 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
We conclude that p53 nuclear overexpression is an early event in bladder cancer, occurring in 48% of cases of carcinoma in situ of the bladder.
|
8015077 |
1994 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
Analysis of p53 tumor suppressor gene mutations and human papillomavirus infection in human bladder cancers.
|
7483675 |
1995 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
Biomarker
|
disease |
BEFREE |
The aneuploidy of tumors correlates with the p53 positivity in bladder cancer.
|
7660508 |
1995 |
|
Malignant neoplasm of urinary bladder
|
0.600 |
GeneticVariation
|
disease |
BEFREE |
The fact that all tumors with mutations of the p53 gene except for one were of high nuclear grade (grade III) suggests that p53 mutation is associated with the progression of bladder cancers.
|
7777479 |
1995 |