|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
HPO |
|
|
|
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The discovery of the tumor suppressor genes, for which loss of function mutations are oncogenic as in the RB gene of the retinoblastoma and p53 gene, has introduced a new concept of oncogenesis which could be useful even in the cure of the neoplasms.
|
1331337 |
1992 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
If both RB1 and TP53 are involved in the initiation of osteosarcoma, the mechanisms for development of the retinoblastoma and osteosarcoma tumors are different.
|
1336709 |
1992 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Classical examples are the Rb-1 gene associated with the development of retinoblastoma and the p53 gene, which is associated with a wider range of neoplasms, including breast cancer.
|
1336726 |
1992 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
LOH affecting p53 was observed in 8 of 17 (47%) of heterozygous patients, while LOH of Rb and the mcc/apc locus was observed in 9 of 27 (33%) and 13 of 39 (33%) of heterozygotes, respectively.
|
1346256 |
1992 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
In addition, we studied the c-myc gene for rearrangements by Southern blotting and assessed expression of the retinoblastoma (Rb) and p53 genes by immunostaining.
|
1361372 |
1992 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Retinoblastoma and p53 gene expression related to relapse and survival in human breast cancer: an immunohistochemical study.
|
1453267 |
1992 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Our findings further implicate Rb and p53 derangements in mammary oncogenesis.
|
1468776 |
1992 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression.
|
1501894 |
1992 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
This element overlaps the basal transcription unit of the Rb promoter, suggesting that p53 suppresses Rb transcription through inhibition of the basal promoter activity.
|
1608930 |
1992 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
However, we found that the expression of Rb and p53 RNA is regulated differently in cell cycle synchronized normal human fibroblasts.
|
1784274 |
1991 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Data concerning mutations of protooncogenes (H-, K-, and N-RAS) and tumor suppressor genes (retinoblastoma and p53 genes) in various common cancers are providing evidence of multiple genetic lesions that occur during the multistage process of carcinogenesis.
|
1910603 |
1991 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Two prostate carcinoma cell lines, DU-145 and PC-3, were examined for abnormalities in the retinoblastoma (Rb) and the p53 putative tumor suppressor genes.
|
1986144 |
1991 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The retinoblastoma sensitivity protein (Rb) and the p53 gene product both appear to function as negative regulators of cell division or abnormal cellular growth in some differentiated cell types.
|
2140509 |
1990 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Here, we used human papilloma virus 16 E6 and E7 oncogenes, which target p53 and Rb tumor suppressor proteins, respectively, to immortalize MECs present in early or late passages of human mammary tissue-derived cultures or in milk.
|
7537374 |
1995 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Two of the three tumors with abnormal Rb expression also had p53 mutations and staining on serial sections demonstrated that selected ovarian cancer cells possessed mutations in both oncogenes.
|
7545631 |
1995 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Genetic changes found in human osteogenic sarcoma cells, including loss of the p53 and Rb tumor suppressor elements and overexpression of the cyclin G1 (CYCG1) proto-oncogene, suggest the potential of gene transfer as a treatment for metastatic disease.
|
7585620 |
1995 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Further characterization of this line demonstrated its clonal origin, with integration of two copies of SV40T at the same site and the presence of both normal retinoblastoma and wild-type p53 proteins.
|
7586160 |
1995 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
However, INK4 mRNA was expressed at high levels in 5 cell lines, and this was associated with deletion or inactivation of the retinoblastoma susceptibility gene product pRB but not with mutation of TP53.
|
7591270 |
1995 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
The HPV E6 and E7 proteins bind to and inactivate the products of the p53 and retinoblastoma (Rb) tumor suppressor genes, which thereby allow the cervical carcinoma cells to circumvent the action of these tumor suppressor genes.
|
7621252 |
1995 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
Involvement of the retinoblastoma susceptibility (RB-1), p16INK4, p53 and telomerase genes in immortalisation was examined by determining their status in 15 human cell lines representing four immortalisation complementation groups.
|
7675456 |
1995 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
For example, both the RB gene of retinoblastoma and the p53 gene, which is commonly mutated in breast and colon cancer among others, produce proteins involved in distinct steps of cell cycle control, while the nm23 product prevents metastasis.
|
7819583 |
1994 |
|
Retinoblastoma
|
0.200 |
AlteredExpression
|
disease |
BEFREE |
Because the E6 and E7 proteins, as well as the SV40 large T antigen, specifically bind to and interfere with the activity of the retinoblastoma (RB) and p53 tumor suppressor proteins, our results suggest that these proteins have critical roles in regulating the proliferation of human corneal endothelial cells.
|
7822156 |
1995 |
|
Retinoblastoma
|
0.200 |
Biomarker
|
disease |
BEFREE |
In the two-stage model of controlling cellular senescence in cultured human fibroblasts, retinoblastoma (Rb) and p53 proteins may be key factors regulating the mortality stage 1 mechanism.
|
7898935 |
1995 |
|
Retinoblastoma
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
These data seem to suggest that whereas mutant type of p53 and retinoblastoma susceptibility genes may exhibit "oncogenic" function in many human tumors, mutational inactivation of these genes may not be an important feature in the carcinogenic development of human papillomavirus-negative small cell cervical carcinomas.
|
7934068 |
1994 |