|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TP53 alteration in primary tumour was significantly associated with the following parameters: positive node status, T status > 1, negative oestrogen receptor status, negative progesterone receptor status, presence of ERBB2 gene amplification, and invasive ductal histology.
|
8102535 |
1993 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Of note, human genomic databases (TCGA, METABRIC etc.) show a high degree of p53 LOH in all examined tumor types that carry missense p53 mutations, including sarcomas and breast carcinomas (with and without HER2 amplification).
|
28277540 |
2017 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HER-2 gene amplification and TP53 gene deletion were detected in CTCs.
|
21527564 |
2011 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found elevated risks of disease recurrence and overall mortality in patients with both p53 mutation and neu/erbB-2 amplification in their tumor compared with patients with neither or only one of the alterations.
|
14701769 |
2004 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
HER-2/neu amplification was identified in 12 of 30 DCIS samples (40%), and p53 mutations were identified in 6 of 30 DCIS samples (20%).
|
11147584 |
2000 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
All cases showing p53 mutations or HER-2 amplification represented protein expression of p53 or HER-2, respectively.
|
9338750 |
1997 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients carrying a TP53 mutation showed a significantly higher likelihood of developing a breast cancer with Human Epidermal growth factor Receptor (HER2) amplification (83%) when compared to the cohort of young onset breast cancer cases (16%); ER and PR status were equivalent between groups.
|
20805372 |
2010 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Heterogeneous gene alterations in primary breast cancer contribute to discordance between primary and asynchronous metastatic/recurrent sites: HER2 gene amplification and p53 mutation.
|
12738987 |
2003 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a significant association between HER-2/neu amplification and deletion of a p53 allele.
|
24399009 |
2013 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Patients with TP53 mutation (-) PIK3CA mutation (-) ERBB2 amplification (+) CCND1 amplification (-), TP53 mutation (+) PIK3CA mutation (-) ERBB2 amplification (+) CCND1 amplification (-) or TP53 mutation (+) PIK3CA mutation (+) ERBB2 amplification (+) CCND1 amplification (-)had significantly higher pCR rates (P < 0.05 for ypT0/isypN0 and ypT0/is) than wild type genotype tumors.
|
30776175 |
2019 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our analysis showed that GAED frequently harbors TP53 mutations and ERBB2 amplification.
|
29751042 |
2018 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Together, resistance to HER2 blockade should be indicated during treatment if any of the following situations applies: 1) recurrence or persistence of HER2 amplification in the blood; 2) emergence or ≥20% increase in the fraction of mutations in any of these resistance-related genes including TP53/PIK3CA/MTOR/PTEN.
|
27602761 |
2016 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TP53 mutational status (exons 2-10) and ERBB2 amplification status were determined in tumor specimens from a prospective cohort of 543 women with node-negative breast cancer.
|
17221157 |
2007 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No such correlation is found for p53 mutations or erbB2 amplification.
|
1306132 |
1992 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Since p53 mutations as well as c-erbB-2 amplification were detected almost selectively in Grade 3 cases but were not associated with lymph nodal status in invasive breast cancer, these two gene alterations could be indicators of prognosis of disease independent of lymph nodal status.
|
8099903 |
1993 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TP53 mutations and ERBB2 amplification were more frequent in SDCXPA than in SDCDN (P = .0007 and P = .01, respectively).
|
30946933 |
2019 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TP53 mutations (15/27, 56%), PTEN loss (11/29, 38%, including 2 cases with PTEN mutation), PIK3CA hotspot mutations (10/30, 33%), HRAS hotspot mutations (10/29; 34%), and ERBB2 amplification (9/29, 31%, including 1 case with mutation) represented the 5 most common abnormalities.
|
25723113 |
2015 |
|
HER2 gene amplification
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with CCNE1 amplification (n = 28), TP53 mutations (n = 23, 82.1%) and ERBB2 amplification (n = 8, 28.6%) were the most frequent concurrent genetic alterations.
|
31178228 |
2019 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
By conventional light microscopy, HER-2/neu amplification (>/=6 copies >50% cancer cells) was detected in 14% (8/59) tumours, HER-2/neu overexpression (>10% cells moderate/strong complete membrane staining) in 22% (13/60) for A0485, and 18% (11/60) for TAB250, p53 (>10% +cells) in 61% (36/59), and Ki-67 (>50% +cells) in 50% (30/60).
|
14752523 |
2004 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
While TOP2alpha and p53 gene amplification was detected in no case, 5 cases (8%) showed HER2 gene amplification, which was related to HER2 3+ score in 4 cases.
|
15816547 |
2005 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additional FISH studies that use probes to the SMS, RARA, and TP53 genes are an effective way to determine the true HER2 amplification status in patients with polysomy 17 and they have important potential implications for guiding HER2-targeted therapy in breast cancer.
|
21947821 |
2011 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, a Fluorescent In Situ Hybridization (FISH) assay for HER2 gene amplification and p53 genotyping was performed on all cell lines.
|
23372829 |
2013 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between TP53 mutation and ERBB2 amplification was confirmed in a wider DCIS cohort using p53 immunohistochemistry as a surrogate marker for TP53 mutations (P=0.03).
|
28338653 |
2017 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
FISH analysis showed erbB-2 gene amplification and p53 deletions in selected CIS, as well as a marked chromosome 17 copy number heterogeneity in all six CIS examined.
|
7672797 |
1995 |
|
HER2 gene amplification
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, we now show that p53 positivity in unamplified 17 polysomy identifies cases that are associated with an even higher Nottingham score and greater hormone receptor negativity that is similar to cases with HER2 amplification.
|
20823770 |
2011 |