TP53, tumor protein p53, 7157

N. diseases: 2494; N. variants: 527
Disease: Glioblastoma Multiforme ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease HPO
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 AlteredExpression disease BEFREE Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53. 2143581 1990
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE Results suggested that aberrations of the p53 gene were not correlated with the malignancy of some types of brain tumors such as anaplastic astrocytoma and glioblastoma, contrary to previous observations on colorectal cancers. 1886708 1991
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE The more malignant histological features of anaplastic astrocytoma and glioblastoma multiforme appear to be reflected by a greater incidence of p53 accumulation. 1336544 1992
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE LOH on chromosome 10 and p53 mutation were found together only in patients with glioblastoma multiforme (22%), suggesting that these genetic changes may accumulate during astrocytoma progression. 1346255 1992
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE A subpopulation of cells were present in the low-grade tumours that contained the same p53 gene mutation predominant in the cells of the recurrent tumours that had progressed to glioblastoma. 1311419 1992
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE Our results show that p53 mutations are not restricted to glioblastoma multiforme and may be important in the tumorigenesis of lower-grade astrocytomas and that p53 mutations in lower-grade astrocytomas are associated with loss of chromosome 17p. 1349850 1992
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE Conditional expression of wild-type (wt) p53 protein in a glioblastoma tumor cell line has been shown to be growth inhibitory. 1409626 1992
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 PosttranslationalModification disease BEFREE Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells. 1630823 1992
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE A correlative study of p53 protein alteration and p53 gene mutation in glioblastoma multiforme. 8293182 1993
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE Here we show that Ser-15 and Ser-9 in the N-terminal transactivation domain of wild-type human p53 are phosphorylated in vivo in cells derived from the human glioblastoma line T98G. 8327466 1993
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE Six astrocytic tumors (one anaplastic astrocytoma and five glioblastoma multiforme) were found to have putative p53 mutations. 7903434 1993
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 AlteredExpression disease BEFREE Mutations in, and aberrant expression of, the p53 tumor suppressor gene were assessed in 17 cell lines derived from human malignant brain tumors (glioblastoma multiforme). 8253536 1993
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE We investigated the accumulation of p53 proteins after heat stress and their association with HSP72/HSC73 using four human glioblastoma cell lines. 7954368 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE We analysed 31 non-glioblastoma astrocytomas for alterations in p53 protein expression and for mutations in the p53 gene. 8108140 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated wild type p53 gene into null glioblastoma cells. 7531056 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE The human glioblastoma cell line SNB-19, which expresses the latent form of TGF-beta, was transfected with a retroviral vector containing wild-type p53 (wt-p53) or p53 with a mutation (mut-p53) at codon 273. 8119773 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE These findings suggest that histologically indistinguishable, low-grade astrocytic gliomas that are destined to progress to higher grades, do so along two distinct clinicopathologic pathways (either stepwise to anaplastic glioma, then glioblastoma, or directly to glioblastoma) marked by the presence or absence of p53 mutation. 8007011 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE We evaluated 35 astrocytic tumors (17 pilocytic, 4 diffuse low grade, 12 anaplastic, and 2 glioblastoma) in pediatric patients for p53 mutations, using polymerase chain reaction-single-stranded conformation polymorphism analysis as a screening technique. 8084407 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 AlteredExpression disease BEFREE Analysis of the p53 gene and its expression in human glioblastoma cells. 8306326 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 AlteredExpression disease BEFREE Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells. 8090761 1994
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 GeneticVariation disease BEFREE This case report describes the use of allele-specific PCR (A-PCR) to detect a C-->T transition in p53 codon 273 in DNA extracted from the cerebrospinal fluid (CSF) of a patient whose glioblastoma contained the same mutation. 7726135 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 AlteredExpression disease BEFREE We have investigated the increased levels of p53 and hsp72 after UV or gamma-ray irradiation and the association of these using two human glioblastoma cell lines. 7600522 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 Biomarker disease BEFREE We addressed this question in glioblastoma, a disease characterized by an unusually high level of intrinsic resistance to therapy and poor prognosis: mean survival time from diagnosis is only about 1 yr. We introduced the gene for wild-type p53 into human T98G glioblastoma cells, which express endogenous mutant p53 but not wild-type p53. 8519417 1995
CUI: C1621958
Disease: Glioblastoma Multiforme
Glioblastoma Multiforme 		0.200 AlteredExpression disease BEFREE In this study, we show that the expression of both wild-type p53 and MDM2 (murine double minute 2) proteins was induced when cis-diamminedichloroplatinum (cisplatin) caused apoptosis in human glioblastoma U87-MG cells, which expressed neither wild-type p53 nor MDM2 protein prior to treatment. 7761100 1995