Glioblastoma
|
0.400 |
Biomarker
|
disease |
MGD |
|
|
|
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Negative growth regulation in a glioblastoma tumor cell line that conditionally expresses human wild-type p53.
|
2143581 |
1990 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Results suggested that aberrations of the p53 gene were not correlated with the malignancy of some types of brain tumors such as anaplastic astrocytoma and glioblastoma, contrary to previous observations on colorectal cancers.
|
1886708 |
1991 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
A subpopulation of cells were present in the low-grade tumours that contained the same p53 gene mutation predominant in the cells of the recurrent tumours that had progressed to glioblastoma.
|
1311419 |
1992 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The more malignant histological features of anaplastic astrocytoma and glioblastoma multiforme appear to be reflected by a greater incidence of p53 accumulation.
|
1336544 |
1992 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Human malignant gliomas (glioblastomas and anaplastic astrocytomas) are the most frequent brain tumors and are associated with a variety of genetic alterations including retinoblastoma (RB) and p53 gene mutations, loss of interferon alpha and beta (IFNA, IFNB) genes and lack of O6-methylguanine-DNA methyltransferase (MGMT) expression.
|
1501894 |
1992 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Our results show that p53 mutations are not restricted to glioblastoma multiforme and may be important in the tumorigenesis of lower-grade astrocytomas and that p53 mutations in lower-grade astrocytomas are associated with loss of chromosome 17p.
|
1349850 |
1992 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Conditional expression of wild-type (wt) p53 protein in a glioblastoma tumor cell line has been shown to be growth inhibitory.
|
1409626 |
1992 |
Glioblastoma
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
Human wild-type p53 adopts a unique conformational and phosphorylation state in vivo during growth arrest of glioblastoma cells.
|
1630823 |
1992 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
LOH on chromosome 10 and p53 mutation were found together only in patients with glioblastoma multiforme (22%), suggesting that these genetic changes may accumulate during astrocytoma progression.
|
1346255 |
1992 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Finally, we suggest that glioblastomas with p53 mutations in the conserved region of the gene may be a subset that are more common in women and in younger patients.
|
8381161 |
1993 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Six astrocytic tumors (one anaplastic astrocytoma and five glioblastoma multiforme) were found to have putative p53 mutations.
|
7903434 |
1993 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Mutations in, and aberrant expression of, the p53 tumor suppressor gene were assessed in 17 cell lines derived from human malignant brain tumors (glioblastoma multiforme).
|
8253536 |
1993 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here we show that Ser-15 and Ser-9 in the N-terminal transactivation domain of wild-type human p53 are phosphorylated in vivo in cells derived from the human glioblastoma line T98G.
|
8327466 |
1993 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These and published data support the view that p53 mutations are frequently involved both in low-grade and progressive (anaplastic) astrocytomas, including glioblastomas multiforme.
|
8397797 |
1993 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Although 30 of 37 glioblastomas analyzed showed concordance for p53 protein expression and p53 gene mutations, a subset of seven glioblastomas showed discordant accumulation of the p53 protein in the absence of any detectable p53 gene mutations.
|
8293182 |
1993 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We analysed 31 non-glioblastoma astrocytomas for alterations in p53 protein expression and for mutations in the p53 gene.
|
8108140 |
1994 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Using a monoclonal antibody that reacts with both mutant and wild-type p53 protein (PAb 1801), reactivity was assessed immunohistochemically in specimens from the first diagnosis of astrocytic neoplasm in 95 patients: 26 astrocytomas (A), 19 anaplastic astrocytomas (AA), and 50 glioblastomas multiforme (GBM).
|
7866633 |
1994 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Glioblastomas with one normal and one mutated copy of the p53 gene and allelic deletions on 17p distal to p53, on the other hand, show predominantly cytoplasmic staining, probably originating from the wild type p53 protein.
|
8261427 |
1994 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The human glioblastoma cell line SNB-19, which expresses the latent form of TGF-beta, was transfected with a retroviral vector containing wild-type p53 (wt-p53) or p53 with a mutation (mut-p53) at codon 273.
|
8119773 |
1994 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We evaluated 35 astrocytic tumors (17 pilocytic, 4 diffuse low grade, 12 anaplastic, and 2 glioblastoma) in pediatric patients for p53 mutations, using polymerase chain reaction-single-stranded conformation polymorphism analysis as a screening technique.
|
8084407 |
1994 |
Glioblastoma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Transcriptional regulation of basic fibroblast growth factor gene by p53 in human glioblastoma and hepatocellular carcinoma cells.
|
8090761 |
1994 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
We investigated the accumulation of p53 proteins after heat stress and their association with HSP72/HSC73 using four human glioblastoma cell lines.
|
7954368 |
1994 |
Glioblastoma
|
0.400 |
Biomarker
|
disease |
BEFREE |
Here, we tested the role of p53 in the angiogenic process by introducing a tetracycline-regulated wild type p53 gene into null glioblastoma cells.
|
7531056 |
1994 |
Glioblastoma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that histologically indistinguishable, low-grade astrocytic gliomas that are destined to progress to higher grades, do so along two distinct clinicopathologic pathways (either stepwise to anaplastic glioma, then glioblastoma, or directly to glioblastoma) marked by the presence or absence of p53 mutation.
|
8007011 |
1994 |