|
Kidney Failure, Acute
|
0.010 |
Biomarker
|
disease |
BEFREE |
To explore the role of ASPP2 in the progression of AKI, we prepared an AKI mouse model induced by ischaemia reperfusion (I/R) in wild-type (ASPP2<sup>+/+</sup> ) mice and ASPP2 haploinsufficient (ASPP2<sup>+/-</sup> ) mice.
|
30675758 |
2019 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our findings provide functional and mechanistic insights into the critical role of ASPP2 in the regulation of the mevalonate pathway and the importance of this pathway in tumor initiation and tumor growth, which may provide a new therapeutic opportunity for HCC.
|
31685796 |
2019 |
|
Gestational Trophoblastic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and ASPP2, have been reported to be dysregulated in GTD.
|
31615473 |
2019 |
|
Gestational trophoblastic disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASPP (Ankyrin-repeat, SH3-domain and proline-rich region containing protein) family proteins, ASPP1 and ASPP2, have been reported to be dysregulated in GTD.
|
31615473 |
2019 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our data not only highlight an important role of ASPP2 in RCC progression and drug resistance, but also reveal new regulatory mechanisms of ASPP2, which provides important insights into novel treatment strategies by targeting ASPP2 dysregulation in RCC.
|
29890207 |
2018 |
|
Malignant neoplasm of gallbladder
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Gallbladder Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Fibrosis, Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASPP2<sup>+/-</sup> and ASPP2+/+ Balb/c mice were used to examine the effects of ASPP2 on liver fibrosis in vivo.
|
29196956 |
2018 |
|
Malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study, migration and invasion assays, apoptosis assay, caspase activity assay, TUNEL staining, real time PCR and western blot were used to investigate the mechanism of ASPP2 regulated by miR-21 in lung cancer in vitro and in vivo.
|
29669316 |
2018 |
|
Conventional (Clear Cell) Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In summary, our data not only highlight an important role of ASPP2 in RCC progression and drug resistance, but also reveal new regulatory mechanisms of ASPP2, which provides important insights into novel treatment strategies by targeting ASPP2 dysregulation in RCC.
|
29890207 |
2018 |
|
Laryngeal Squamous Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Endocrine resistance (CCND1, RAF1, RB1, and SMAD2) and Hippo signaling pathway (CCND1, LATS1, SMAD2, and TP53BP2) could be of importance in LSCC, because they had high connectivity degrees in the blue module.
|
29443735 |
2018 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Apoptosis-stimulating protein of p53 (ASPP2), a tumorigenesis related protein, plays a critical role in the initiation and development of various types of cancers.
|
29669316 |
2018 |
|
Carcinoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study, migration and invasion assays, apoptosis assay, caspase activity assay, TUNEL staining, real time PCR and western blot were used to investigate the mechanism of ASPP2 regulated by miR-21 in lung cancer in vitro and in vivo.
|
29669316 |
2018 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of ASPP2 decreased progressively from NEE to LGIN, to HGIN, and to ESCC, and it was related to TNM stage, histological differentiation and lymph node metastasis in ESCC (P < 0.05).
|
29747775 |
2018 |
|
Primary malignant neoplasm of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the study, migration and invasion assays, apoptosis assay, caspase activity assay, TUNEL staining, real time PCR and western blot were used to investigate the mechanism of ASPP2 regulated by miR-21 in lung cancer in vitro and in vivo.
|
29669316 |
2018 |
|
Liver regeneration disorder
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
However, the role of ASPP2 in hepatocyte proliferation and liver regeneration has not been reported.
|
30560875 |
2018 |
|
High Grade Intraepithelial Neoplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression of ASPP2 decreased progressively from NEE to LGIN, to HGIN, and to ESCC, and it was related to TNM stage, histological differentiation and lymph node metastasis in ESCC (P < 0.05).
|
29747775 |
2018 |
|
Stage 0 Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Stage IIA Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Stage IIB Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Stage III Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Stage IV Gallbladder Cancer AJCC v8
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our data showed that downregulation of ASPP2 in patients with GBC was linked to poor prognosis.
|
30389910 |
2018 |
|
Invasive Lobular Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Notably, MYH9, PPP1R12B and TP53BP2 were also frequently aberrated in human ILC, highlighting these genes as drivers of a novel oncogenic pathway underlying ILC development.
|
28650484 |
2017 |
|
Peritoneal dissemination
|
0.010 |
Biomarker
|
disease |
BEFREE |
ASPP2 suppressed migration and invasion of GC cells in vitro and peritoneal dissemination of GC cells in vivo in a mouse model.
|
28400336 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In this study, we report that downregulation of ASPP2, a member of the ankyrin-repeat-containing, SH3-domain-containing, and proline-rich-region-containing protein (ASPP) family, bestowed HCC cells with stem-like properties and resistance to chemotherapy, including the expansion of side population fractions, formation of hepatospheroids, expression of stem cell-associated genes, loss of chemosensitivity, and increased tumorigenicity in immunodeficient mice.
|
27473084 |
2016 |