Leukemia, Myelocytic, Acute
|
0.190 |
Biomarker
|
disease |
BEFREE |
Establishment of a cell line with AML1-MTG8, TP53, and TP73 abnormalities from acute myelogenous leukemia.
|
11550287 |
2001 |
Leukemia, Myelocytic, Acute
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
Gene expression of p73 was detected by reverse transcriptase-polymerase chain reaction (RT-PCR) in cell lines (5 of 7 pre B/B-acute lymphoblastic leukemia [ALL], 13 of 21 T-ALL/lymphoblastic lymphomas [LBL], 9 of 10 B-non-Hodgkin's lymphomas [B-NHL], 8 of 9 acute myelogenous leukemias [AML], 2 of 2 T-NHL, 3 of 3 multiple myeloma), and in patient samples (16 of 23 pre B-ALL, 5 of 8 T-ALL/LBL, 5 of 8 B-NHL).
|
10419905 |
1999 |
Leukemia, Myelocytic, Acute
|
0.190 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia.
|
27903959 |
2017 |
Leukemia, Myelocytic, Acute
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
In addition, biallelic expression of p73 occurs in normal bone marrows, some AML samples, and specific cell lines.
|
10400412 |
1999 |
Leukemia, Myelocytic, Acute
|
0.190 |
GeneticVariation
|
disease |
LHGDN |
Only six AML patients showed p73 mRNA expression, as analyzed by RT-PCR analysis.
|
15849769 |
2005 |
Leukemia, Myelocytic, Acute
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
Overexpression of p73 protein and aberrant expression of its particular isoforms, with very low frequency of P73 hypermethylation or mutations, were found in malignant myeloproliferations, including acute myeloblastic leukemia.
|
16541141 |
2006 |
Leukemia, Myelocytic, Acute
|
0.190 |
Biomarker
|
disease |
BEFREE |
RARbeta is methylated in 18% and p73 in 10% of AMLs.
|
15495254 |
2004 |
Leukemia, Myelocytic, Acute
|
0.190 |
PosttranslationalModification
|
disease |
BEFREE |
The p73 promoter was hypermethylated in AML cell lines and in primary AML cells but not in epithelial cells, which were resistant toward 5-Aza-CdR.
|
15609309 |
2005 |
Leukemia, Myelocytic, Acute
|
0.190 |
PosttranslationalModification
|
disease |
BEFREE |
The promoter of p73 was hypermethylated in AML cell lines in vitro and in primary AML cells ex vivo but not in DAC-resistant epithelial cells.
|
16193303 |
2005 |
Leukemia, Myelocytic, Acute
|
0.190 |
GeneticVariation
|
disease |
BEFREE |
This report is the first demonstrating the presence of mutations in p73 gene in acute myelogenous leukemia.
|
15849769 |
2005 |
Leukemia, Myelocytic, Acute
|
0.190 |
AlteredExpression
|
disease |
BEFREE |
Thus, the distinct gene expression profile of p73 further supports the notion that acute promyelocytic leukemia is a biologically different subset of AML.
|
15385938 |
2004 |