|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASDB |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this post hoc analysis of cross-sectional data from US participants in the Comparison of AMD Treatments Trials, genotyping was performed in 835 participants with TaqMan assays for the SNPs rs1061170 (Y402H variant in CFH), rs800292 (rs800292" genes_norm="3075">I62V variant in CFH), rs10490924 (rs10490924;s10490924" genes_norm="387715;717">A69S variant in ARMS2), rs11200638 (HTRA1), rs547154 (C2), rs2230199 (rs2230199" genes_norm="5654;718">R102G variant in C3), rs10468017 (LIPC), and rs4151667 (L9H variant in CFB).
|
29801032 |
2018 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Association between genetic variation of complement C3 and the susceptibility to advanced age-related macular degeneration: a meta-analysis.
|
30352574 |
2018 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
While significant but modest associations were identified between the complement factor H, the age-related maculopathy susceptibility protein 2, and the complement component 3 single nucleotide polymorphisms and AD, these were different in direction or genetic model to that observed in AMD.
|
22300950 |
2012 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we investigated the associations of haplotype-tagging single nucleotide polymorphisms (SNPs) in the complement component 3 (C3) gene with both neovascular AMD and PCV, and potential epistatic effects on C3.
|
25388911 |
2014 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Complement C3 variant and the risk of age-related macular degeneration.
|
17634448 |
2007 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
Our study showed a significant association between variants in the C3 gene and AMD and further highlights the crucial role of the complement pathway in the etiology of AMD.
|
19168221 |
2009 |
|
Age related macular degeneration
|
0.700 |
GeneticVariation
|
disease |
GWASCAT |
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.
|
21665990 |
2011 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Variation in complement factor 3 is associated with risk of age-related macular degeneration.
|
17767156 |
2007 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Rare variants in CFI, C3 and C9 are associated with high risk of advanced age-related macular degeneration.
|
24036952 |
2013 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3 Inhibitor Pegcetacoplan for Geographic Atrophy Secondary to Age-Related Macular Degeneration: A Randomized Phase 2 Trial.
|
31474439 |
2020 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
Identification of a rare coding variant in complement 3 associated with age-related macular degeneration.
|
24036949 |
2013 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement C3, C2, and factor B gene polymorphisms and age-related macular degeneration in a Greek cohort study.
|
24519512 |
2014 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Joint association of complement component 3 and CC-cytokine ligand2 (CCL2) or complement component 3 and CFH polymorphisms in age-related macular degeneration.
|
28095095 |
2017 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
CTD_human |
A rare nonsynonymous sequence variant in C3 is associated with high risk of age-related macular degeneration.
|
24036950 |
2013 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Systematic review and meta-analysis of the association between complement component 3 and age-related macular degeneration: a HuGE review and meta-analysis.
|
21576320 |
2011 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
BEFREE |
Complement component 3: an assessment of association with AMD and analysis of gene-gene and gene-environment interactions in a Northern Irish cohort.
|
20157618 |
2010 |
|
Age related macular degeneration
|
0.700 |
Biomarker
|
disease |
LHGDN |
Variation in complement factor 3 is associated with risk of age-related macular degeneration.
|
17767156 |
2007 |
|
Age related macular degeneration
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Estimation of systemic complement C3 activity in age-related macular degeneration.
|
17420372 |
2007 |