Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.010 Biomarker disease BEFREE Molecular cloning of human TAK1 and its mutational analysis in human lung cancer. 9466656 1998
CUI: C0684249
Disease: Carcinoma of lung
Carcinoma of lung 		0.010 Biomarker disease BEFREE Molecular cloning of human TAK1 and its mutational analysis in human lung cancer. 9466656 1998
CUI: C1306460
Disease: Primary malignant neoplasm of lung
Primary malignant neoplasm of lung 		0.010 Biomarker disease BEFREE Molecular cloning of human TAK1 and its mutational analysis in human lung cancer. 9466656 1998
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.020 Biomarker disease BEFREE Treating leukemia cells with an antisense oligonucleotide complementary to the WT1 gene resulted in reduced TAK-1-mediated cytotoxicity, suggesting that target antigen of TAK-1 on leukemia cells is the naturally processed WT1 peptide in the context of HLA-A24. 10607714 2000
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.020 Biomarker disease BEFREE Treating leukemia cells with an antisense oligonucleotide complementary to WT1 reduced TAK-1-mediated cytotoxicity. 11699391 2001
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.070 Biomarker disease BEFREE By RT-PCR analysis, the TAK1 gene located at these loci did not correlate with LOH status, indicating that TAK1 is not a target gene in prostate carcinoma. 12967473 2003
CUI: C0206664
Disease: Teratocarcinoma
Teratocarcinoma 		0.010 Biomarker disease BEFREE To further study the potential roles of TR4 during cell differentiation, a tetracycline-inducible system with anti-sense TR4 in teratocarcinoma P19 cell lines was generated to analyze the retinoic acid-induced differentiation of these cells. 15381082 2004
CUI: C0009319
Disease: Colitis
Colitis 		0.010 Biomarker disease BEFREE Together, the results show that TAK1, by controlling the generation of central Treg cells, is important for preventing spontaneously developing colitis. 16940043 2006
CUI: C0025202
Disease: melanoma
melanoma 		0.040 Biomarker disease BEFREE The data indicate that H11/HspB8 overload causes melanoma growth arrest and apoptosis through TAK1 activation and suggest that H11/HspB8 is a promising molecular therapy target. 17173073 2007
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.100 Biomarker phenotype BEFREE Together, these findings suggest that TAK1 contributes to TGF-beta1-mediated tumor angiogenesis and metastasis via a mechanism involving the TAK1-NF-kappaB-MMP-9 pathway. 17828308 2008
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE The orthotopic xenograft studies in SCID mice showed that suppression of TAK1 signaling by dn-TAK1 reduces tumor growth and formation of lung metastases. 17828308 2008
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.080 AlteredExpression phenotype BEFREE We found that suppression of TAK1 signaling by dominant-negative (dn) TAK1 or RNA interference (siRNA) reduces expression of MMP-9 and tumor cell invasion, without growth inhibition in cell culture. 17828308 2008
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast 		0.070 Biomarker disease BEFREE Here, we present evidence that TGF-beta-activated protein kinase 1 (TAK1) is critical for TGF-beta regulation of MMP-9 and the metastatic potential of breast cancer cell line MDA-MB-231. 17828308 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE Here, we present evidence that TGF-beta-activated protein kinase 1 (TAK1) is critical for TGF-beta regulation of MMP-9 and the metastatic potential of breast cancer cell line MDA-MB-231. 17828308 2008
CUI: C0153676
Disease: Secondary malignant neoplasm of lung
Secondary malignant neoplasm of lung 		0.020 Biomarker disease BEFREE The orthotopic xenograft studies in SCID mice showed that suppression of TAK1 signaling by dn-TAK1 reduces tumor growth and formation of lung metastases. 17828308 2008
CUI: C1519666
Disease: Tumor-Associated Vasculature
Tumor-Associated Vasculature 		0.010 Biomarker disease BEFREE Dn-TAK1 reduced the proliferation Ki-67 index and neovasculature of orthotopic xenografts. 17828308 2008
CUI: C1519670
Disease: Tumor Angiogenesis
Tumor Angiogenesis 		0.010 Biomarker phenotype BEFREE Together, these findings suggest that TAK1 contributes to TGF-beta1-mediated tumor angiogenesis and metastasis via a mechanism involving the TAK1-NF-kappaB-MMP-9 pathway. 17828308 2008
CUI: C0010346
Disease: Crohn Disease
Crohn Disease 		0.020 GeneticVariation disease BEFREE MDP-induced tolerance was independent of receptor downregulation but was associated with reduced levels of phosphorylated TAK1 and abrogated phosphorylation of the downstream MAPK.Since Nod2 mutations have been associated with susceptibility to develop Crohn's disease (CD), we compared the MDP-induced tolerance in healthy donors and CD patients with compound heterozygous Nod2 mutations (Mut-Nod2) expressing variant NOD2 proteins. 19572373 2009
CUI: C3539920
Disease: ECTODERMAL DYSPLASIA 11B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE
ECTODERMAL DYSPLASIA 11B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE 		0.010 GeneticVariation disease BEFREE To determine frequency of EDARADD, TRAF6, TAB2 and TAK1 mutations in HED. 20222921 2010
CUI: C3541517
Disease: ECTODERMAL DYSPLASIA 11A, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL DOMINANT
ECTODERMAL DYSPLASIA 11A, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL DOMINANT 		0.010 GeneticVariation disease BEFREE To determine frequency of EDARADD, TRAF6, TAB2 and TAK1 mutations in HED. 20222921 2010
CUI: C3887494
Disease: ECTODERMAL DYSPLASIA 10B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE
ECTODERMAL DYSPLASIA 10B, HYPOHIDROTIC/HAIR/TOOTH TYPE, AUTOSOMAL RECESSIVE 		0.010 GeneticVariation disease BEFREE To determine frequency of EDARADD, TRAF6, TAB2 and TAK1 mutations in HED. 20222921 2010
CUI: C3888065
Disease: ECTODERMAL DYSPLASIA 10A, HYPOHIDROTIC/HAIR/NAIL TYPE, AUTOSOMAL DOMINANT
ECTODERMAL DYSPLASIA 10A, HYPOHIDROTIC/HAIR/NAIL TYPE, AUTOSOMAL DOMINANT 		0.010 GeneticVariation disease BEFREE To determine frequency of EDARADD, TRAF6, TAB2 and TAK1 mutations in HED. 20222921 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.070 Biomarker disease BEFREE TAK1-TAB2 signaling contributes to bone destruction by breast carcinoma cells. 21700681 2011
CUI: C0153690
Disease: Secondary malignant neoplasm of bone
Secondary malignant neoplasm of bone 		0.020 Biomarker disease BEFREE These findings identify the TAK1-TAB2 axis as a potential therapeutic target in bone metastasis. 21700681 2011
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.010 GeneticVariation disease BEFREE It identified two high-ranking, biologically interesting interactions: (1) rs748120 of NR2C2 and subregions of 8q24 that contain independent susceptibility loci specific to PRCA and (2) rs4810671 of SULF2 and both JAZF1 and HNF1B that are associated with PRCA and type 2 diabetes. 22086326 2011