C3AR1, complement C3a receptor 1, 719

N. diseases: 73; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C2749604
Disease: HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1
HEMOLYTIC UREMIC SYNDROME, ATYPICAL, SUSCEPTIBILITY TO, 1 		0.100 GeneticVariation disease CLINVAR
CUI: C0026769
Disease: Multiple Sclerosis
Multiple Sclerosis 		0.010 Biomarker disease BEFREE However, a strong C3aR staining was evident in areas of inflammation in multiple sclerosis and bacterial meningitis. 9531317 1998
CUI: C0085437
Disease: Meningitis, Bacterial
Meningitis, Bacterial 		0.010 Biomarker group BEFREE However, a strong C3aR staining was evident in areas of inflammation in multiple sclerosis and bacterial meningitis. 9531317 1998
CUI: C0004096
Disease: Asthma
Asthma 		0.250 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C0036690
Disease: Septicemia
Septicemia 		0.020 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C0243026
Disease: Sepsis
Sepsis 		0.020 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C0032285
Disease: Pneumonia
Pneumonia 		0.010 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C3714636
Disease: Pneumonitis
Pneumonitis 		0.010 AlteredExpression disease BEFREE These results demonstrate the expression of C3aR and C5aR by cells endogenous to the lung, and, given the participation of bronchial epithelial and smooth muscle cells in the pathology of diseases such as sepsis and asthma, the data suggest a role for these receptors during lung inflammation. 11160252 2001
CUI: C0004096
Disease: Asthma
Asthma 		0.250 AlteredExpression disease LHGDN Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma. 15039137 2004
CUI: C0021368
Disease: Inflammation
Inflammation 		0.010 AlteredExpression phenotype LHGDN Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma. 15039137 2004
CUI: C0024117
Disease: Chronic Obstructive Airway Disease
Chronic Obstructive Airway Disease 		0.010 AlteredExpression disease LHGDN Complement factors c3a, c4a, and c5a in chronic obstructive pulmonary disease and asthma. 15039137 2004
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker disease RGD Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. 15159277 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.250 GeneticVariation disease BEFREE A patient-only association study suggested that severity of childhood BA was associated with 1526G/A of the C3AR1 gene (P = 0.0057). 15278436 2004
CUI: C0011303
Disease: Demyelinating Diseases
Demyelinating Diseases 		0.010 Biomarker group BEFREE However, the role that C3a and the C3aR play in chronic inflammation, such as in the demyelinating disease experimental autoimmune encephalomyelitis (EAE), remains unclear. 15383607 2004
CUI: C0014070
Disease: Encephalomyelitis
Encephalomyelitis 		0.010 Biomarker disease BEFREE C3aR-deficient (C3aR(-/-)) mice had a significantly attenuated course of EAE compared with control mice during the chronic phase of the disease. 15383607 2004
CUI: C0004096
Disease: Asthma
Asthma 		0.250 GeneticVariation disease BEFREE Support for a causal role for altered anaphylatoxin production in human disease comes from reports of exaggerated complement production in the lungs of asthmatics as well as the association of asthma with polymorphisms in C3/C3aR genes. 16091207 2005
CUI: C0035222
Disease: Respiratory Distress Syndrome, Adult
Respiratory Distress Syndrome, Adult 		0.200 Therapeutic disease RGD Complement inhibitors selectively attenuate injury following administration of cobra venom factor to rats. 16782534 2006
CUI: C0024143
Disease: Lupus Nephritis
Lupus Nephritis 		0.010 AlteredExpression disease LHGDN However, glomerular C3aR staining was detected in 42.9% of lupus-N specimens in association with immunoglobulin G immune-complex depositions. 17472841 2007
CUI: C0004096
Disease: Asthma
Asthma 		0.250 Biomarker disease RGD Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. 17544263 2007
CUI: C0024115
Disease: Lung diseases
Lung diseases 		0.200 Biomarker group RGD Use of monoclonal antibodies to assess expression of anaphylatoxin receptors in rat and murine models of lung inflammation. 17544263 2007
CUI: C0021051
Disease: Immunologic Deficiency Syndromes
Immunologic Deficiency Syndromes 		0.010 Biomarker group BEFREE In agreement with the murine data, blockage of C3aR on human umbilical cord blood CD34(+) cells by C3aR antagonist SB290157 impairs their engraftment in non-obese diabetic/severe combined immunodeficient mice. 19357704 2009
CUI: C0019061
Disease: Hemolytic-Uremic Syndrome
Hemolytic-Uremic Syndrome 		0.010 Biomarker disease BEFREE The functional role of C3a was documented by data showing that glomerular fibrin(ogen), platelet clumps, and TM loss were markedly decreased in HUS mice receiving C3aR antagonist. 21642543 2011
CUI: C0856825
Disease: Acute GVH disease
Acute GVH disease 		0.010 Biomarker disease BEFREE T cells deficient in C3a receptor (C3aR) and/or C5a receptor (C5aR) responded weakly in allogeneic hosts and exhibited limited ability to induce GvHD. 22585573 2012
CUI: C0004364
Disease: Autoimmune Diseases
Autoimmune Diseases 		0.030 Biomarker group BEFREE Complement activation products C3a and C5a have broad pro-inflammatory potential through their receptors, C3aR and C5aR, and contribute to the pathogenesis of several inflammatory and autoimmune diseases, but their roles in IgAN are poorly defined. 24327134 2014
CUI: C1956346
Disease: Coronary Artery Disease
Coronary Artery Disease 		0.020 GeneticVariation disease BEFREE Candidate pathway-based GWAS identified positive association between variants in C3AR1 and C6 and CAD. 25249547 2014