|
Malignant neoplasm of breast
|
0.300 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
(-)-Englerin A ((-)-EA) has a rapid and potent cytotoxic effect on several types of cancer cell that is mediated by plasma membrane ion channels containing transient receptor potential canonical 4 (TRPC4) protein.
|
27875305 |
2017 |
|
Malignant Head and Neck Neoplasm
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Head and Neck Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Malignant neoplasm of kidney
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Renal carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRPC4 was found to be closely associated with incidence of head and neck cancer and poor survival of patients with kidney cancer.
|
26708603 |
2016 |
|
Malignant Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
|
30038709 |
2018 |
|
Primary malignant neoplasm
|
0.030 |
Biomarker
|
group |
BEFREE |
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
|
30038709 |
2018 |
|
Visceral Pain
|
0.200 |
Biomarker
|
phenotype |
RGD |
A rat knockout model implicates TRPC4 in visceral pain sensation.
|
24388923 |
2014 |
|
Graft-vs-Host Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Additionally, expression analysis identified PLEC, C8orf48, TRPC4, and ZNF14, as differentially regulated genes in senescent hMSCs that were similarly regulated in those hMSCs which failed to produce a therapeutic effect in a GVHD trial.
|
24496748 |
2014 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
BT-549 and Hs578T cells express high levels of TRPC4 and TRPC1/4, respectively, and are exquisitely, 2000- and 430-fold, more sensitive to englerin A than other TNBC cell lines.
|
31230251 |
2019 |
|
Right Ventricular Hypertrophy
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Ca<sup>2+</sup> handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.
|
29634917 |
2018 |
|
Primary Myelofibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, immunoblotting revealed that Stim2 levels remained constant as compared to N-ECFCs, while Stim1, Orai1, Orai3, TRPC1 and TRPC4 proteins were over-expressed in PMF-ECFCs.
|
24603752 |
2014 |
|
Focal cortical dysplasia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Elevated Expression of TRPC4 in Cortical Lesions of Focal Cortical Dysplasia II and Tuberous Sclerosis Complex.
|
28455787 |
2017 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Englerin A Agonizes the TRPC4/C5 Cation Channels to Inhibit Tumor Cell Line Proliferation.
|
26098886 |
2015 |
|
Pulmonary Hypertension
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
Enhanced expression of transient receptor potential channels in idiopathic pulmonary arterial hypertension.
|
15358862 |
2004 |
|
Renal Cell Carcinoma
|
0.010 |
Biomarker
|
disease |
LHGDN |
Further analysis revealed a profound decrease in transient receptor potential canonical ion channel 4 (TRPC4) Ca(2+) channel expression in RCC cells.
|
18021253 |
2007 |
|
Esophageal Neoplasms
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.
|
22960999 |
2012 |
|
Diastolic blood pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk.
|
28135244 |
2017 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In accordance, cortisol level tended to be higher in fish fed both supplemented diets at LD compared to fish fed CTRL, but was lower in fish fed TRP4 than in those fed TRP2 under HD condition.
|
31118899 |
2019 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
In accordance, cortisol level tended to be higher in fish fed both supplemented diets at LD compared to fish fed CTRL, but was lower in fish fed TRP4 than in those fed TRP2 under HD condition.
|
31118899 |
2019 |
|
Cerebellar medulloblastoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
OGR1 and TRPC4 are prominently expressed in healthy cerebellar tissue throughout postnatal development and in primary cerebellar medulloblastoma tissues.
|
28627017 |
2017 |
|
Tumor Cell Invasion
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Our results suggest that OGR1 enhances expression of TRPC4-containing channels that contribute to enhanced invasion and metastasis of granule precursor-derived human medulloblastoma.
|
28627017 |
2017 |