|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
We aimed to determine the changes in TRPM2 and autophagic-apoptotic gene expression levels in human prostate adenocarcinomas, and to investigate the affect of TRPM2 on autophagic pathways in PC-3 cell line.
|
30888515 |
2019 |
|
Adult Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to evaluate the effect of combination therapy of RESV and PAX on activation of TRPM2 in DBTRG glioblastoma cells.
|
30984336 |
2019 |
|
Adult Glioblastoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
TRPM2 seems to be a candidate for gene therapy in glioblastoma cells, since the insertion of TRPM2 into A172 cells can facilitate cell death through Ca2+ increase after H2O2 treatment without increasing malignancy.
|
18225560 |
2008 |
|
Adult Glioblastoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
The aim of this study was to evaluate the effect of combination therapy of DTX and Se on activation of TRPM2 in DBTRG glioblastoma cells.
|
30796690 |
2019 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
TRPM2 dependence of ROS-induced NLRP3 activation in Alzheimer's disease.
|
29107864 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
The 'hypothesis' based on these new findings discusses the prospect of considering the TRPM2 channel as a novel therapeutic target for intervening AD and age-related dementia.
|
30009973 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Emerging evidence supports an important role for the ROS-sensitive TRPM2 channel in mediating age-related cognitive impairment in Alzheimer's disease (AD), particularly neurotoxicity resulting from generation of excessive neurotoxic Aβ peptides.
|
29416015 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Transient receptor potential melastatin 2 (TRPM2) is an oxidative stress sensing calcium-permeable channel that is thought to contribute to calcium dysregulation associated with neurodegenerative diseases, including Alzheimer's disease.
|
26558786 |
2015 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
We investigated the mechanisms by which Aβ<sub>42</sub> activates the TRPM2 channel in microglial cells and the relationships to microglial activation and generation of tumor necrosis factor-α (TNF-α), a key cytokine implicated in AD.
|
29143372 |
2018 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
GeneticVariation
|
disease |
LHGDN |
We found a heterozygous variant of TRPM2 in a subset of Guamanian ALS (ALS-G) and PD (PD-G) cases.
|
19004782 |
2008 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
TRPM7 and TRPM2-Candidate susceptibility genes for Western Pacific ALS and PD?
|
17395433 |
2007 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We found a heterozygous variant of TRPM2 in a subset of Guamanian ALS (ALS-G) and PD (PD-G) cases.
|
19004782 |
2008 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, the results of the present study demonstrated that the TRPM2 overexpression in a PDAC cell line (PANC‑1) promoted cell proliferation, invasion and metastatic ability.
|
29620272 |
2018 |
|
Anxiety
|
0.020 |
Biomarker
|
disease |
BEFREE |
The main findings of our study were: (a) TRPM2-KO had a protective effect on epilepsy; (b) TRPM2-KO improved spatial memory deficits overtime during epilepsy, but it did not improve anxiety; (c) the protective effect probably occurred via the PARP1 downstream signaling pathway; (d) TRPM2-KO could ameliorate epilepsy-induced hippocampal pathological damages and weaken astrocyte activation.
|
31794795 |
2020 |
|
Anxiety
|
0.020 |
Biomarker
|
disease |
BEFREE |
Trpm2-deficient mice exhibited BD-related behavior such as increased anxiety and decreased social responses, along with disrupted EEG functional connectivity.
|
26311765 |
2015 |
|
Anxiety Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
Trpm2-deficient mice exhibited BD-related behavior such as increased anxiety and decreased social responses, along with disrupted EEG functional connectivity.
|
26311765 |
2015 |
|
Anxiety Disorders
|
0.020 |
Biomarker
|
group |
BEFREE |
The main findings of our study were: (a) TRPM2-KO had a protective effect on epilepsy; (b) TRPM2-KO improved spatial memory deficits overtime during epilepsy, but it did not improve anxiety; (c) the protective effect probably occurred via the PARP1 downstream signaling pathway; (d) TRPM2-KO could ameliorate epilepsy-induced hippocampal pathological damages and weaken astrocyte activation.
|
31794795 |
2020 |
|
Aortic coarctation
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The locus on 21q22.3 in the sporadic CoA cohort overlapped with a gene locus identified in all familial cases of CoA (candidate gene TRPM2).
|
25984793 |
2015 |
|
Autism Spectrum Disorders
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we propose that the interaction between CD38 and TRPM2 seems to be a new mechanism for stress-induced release of OT, which may result in anxiolytic effects for temporal recovery from social impairments in children with autism spectrum disorder during hyperthermia.
|
28736241 |
2018 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Previous work from our group has shown that <i>Cd38<sup>-/-</sup></i> mice develop a milder pristane-induced lupus disease than WT or <i>Art2<sup>-/-</sup></i> counterparts, demonstrating a new role for CD38 in promoting aberrant inflammation and lupus-like autoimmunity via a Transient Receptor Potential Melastatin 2 (TRPM2)-dependent apoptosis-driven mechanism.
|
30257456 |
2018 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Oxidant sensor cation channel TRPM2 regulates neutrophil extracellular trap formation and protects against pneumoseptic bacterial infection.
|
29906250 |
2018 |
|
Bipolar Disorder
|
0.370 |
Biomarker
|
disease |
BEFREE |
The brains of Trpm2(-/-) mice showed a marked increase in phosphorylated glycogen synthase kinase-3 (GSK-3), a key element in BD-like behavior and a target of lithium.
|
26311765 |
2015 |
|
Bipolar Disorder
|
0.370 |
GeneticVariation
|
disease |
BEFREE |
A significant association of iPLA2β variants with BD-I and a trend gene-gene interaction between iPLA2β and TRPM2 provides additional support for the notion that genetic variation in these two functionally implicated candidates contributes toward the risk and pathophysiology of this illness.
|
23277130 |
2013 |
|
Bipolar Disorder
|
0.370 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest genetic variants of the TRPM2 gene increase risk for BD and support the notion that TRPM2 may be involved in the pathophysiology of BD.
|
16252251 |
2006 |
|
Bipolar Disorder
|
0.370 |
Biomarker
|
disease |
CTD_human |
Chronic oxidative stress modulates TRPC3 and TRPM2 channel expression and function in rat primary cortical neurons: relevance to the pathophysiology of bipolar disorder.
|
23602965 |
2013 |