Corrigendum: The neuroprotective action of dexmedetomidine on apoptosis, calcium entry and oxidative stress in cerebral ischemia-induced rats: Contribution of TRPM2 and TRPV1 channels.
Activation of transient receptor potential melastatin 2 (TRPM2), an oxidative stress-sensitive Ca<sup>2+</sup>-permeable channel, contributes to the aggravation of cerebral ischemia-reperfusion (CIR) injury.
These data suggest persistent TRPM2 activity following ischemia contributes to impairments of the surviving hippocampal network and that inhibition of TRPM2 channels at chronic time points may represent a novel strategy to improve functional recovery following cerebral ischemia that is independent of neuroprotection.