Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results indicated that immunization with an autologous TSHR antigen, TSHR739, induced Graves'-like disease in mice, and that TSHR739 is a candidate autoantigen in autoimmune thyroid disease.
|
23538203 |
2013 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The measurement of autoantibodies to thyroid-stimulating hormone receptor (TSHR) is important for the diagnosis of autoimmune thyroid disease such as Graves' disease (GD).
|
23852019 |
2013 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thyrotropin receptor and leukocyte adhesion molecules in autoimmune thyroid disease: a study of their gene expression by northern blot analysis and in situ hybridization.
|
7524954 |
1994 |
Autoimmune thyroid disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Three of the TSH receptor mutants, deletions of residues 295-306 and 387-395 and the point mutation of cysteine 301 to serine, are shown to be particularly useful in these assays and may be useful to clarify the pathogenetic role and clinical significance of stimulating TSHRAbs in patients with autoimmune thyroid disease who also have blocking TSHRAbs.
|
8100829 |
1993 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Speculation is presented which suggests that elimination of negative regulation of MHC class I and the TSH receptor is an important factor in the development of autoimmune thyroid disease.(ABSTRACT TRUNCATED AT 400 WORDS)
|
1283175 |
1992 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Prevalence and clinical relevance of thyroid stimulating hormone receptor-blocking antibodies in autoimmune thyroid disease.
|
28439882 |
2017 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thyrotropin receptor T cell epitopes in autoimmune thyroid disease.
|
7535671 |
1995 |
Autoimmune thyroid disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of thyroid-stimulating hormone receptor in OLP lesions suggests that mechanisms related to autoimmune thyroid disease are involved in the aetiology of OLP.
|
29500871 |
2018 |
Autoimmune thyroid disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The present study was initiated to characterize thyrotropin receptor (TSH-R) expression in thyroids from patients with Graves' disease, as well as parameters that influence TSH-R expression either causally, such as interferon-gamma (IFN-gamma), the leading candidate among the cytokines thought to play a key role in the initiation of autoimmune thyroid disease, or therapeutically, such as iodide, which is used to prepare patients for surgery.
|
8981006 |
1996 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSH receptor antibodies (TRAbs) are characteristic indicators for the common autoimmune thyroid disease Graves disease (GD).
|
29265783 |
2018 |
Autoimmune thyroid disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Expression levels of the thyrotropin receptor gene in autoimmune thyroid disease: coregulation with parameters of thyroid function and inverse relation to major histocompatibility complex classes I and II.
|
8496329 |
1993 |
Autoimmune thyroid disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between thyroid stimulating hormone receptor gene intron polymorphisms and autoimmune thyroid disease in a Chinese Han population.
|
22673349 |
2012 |
Autoimmune thyroid disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Future studies should focus on the regulation of this transcript, as well as on the role TSH and TSH receptor may play in modulating local lymphokine activation of T and B cells, both in normal conditions and in autoimmune thyroid disease.
|
1824338 |
1991 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Site-directed mutagenesis of a portion of the extracellular domain of the rat thyrotropin receptor important in autoimmune thyroid disease and nonhomologous with gonadotropin receptors. Relationship of functional and immunogenic domains.
|
1655787 |
1991 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The presence of a thyroidal mRNA encoding both the signal peptide and ligand-binding region of the hTSHR, but not the seven transmembrane helices, provides the potential to produce soluble receptors which could play important roles in thyroid physiology and/or autoimmune thyroid disease.
|
1530609 |
1992 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
TSH receptor antibody testing should be considered in pregnant women with any history of autoimmune thyroid disease and symptoms of fetal hyperthyroidism.
|
27813690 |
2017 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autoantibodies that occur in autoimmune thyroid disease and that interact with the TSH receptor are reviewed.
|
3319587 |
1987 |
Autoimmune thyroid disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A polymorphism in the extracellular domain of the thyrotropin receptor is highly associated with autoimmune thyroid disease in females.
|
7544179 |
1995 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TSH-receptor (TSH-R) and thyroid peroxidase (TPO) are targets of autoantibody production in the autoimmune thyroid disease, Graves' disease, and are also likely to be the target of T-cell responses.
|
8397716 |
1993 |
Autoimmune thyroid disease
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of autoimmune thyroid disease with microsatellite markers for the thyrotropin receptor gene and CTLA-4 in Japanese patients.
|
11081251 |
2000 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Since the TSAb and TSBAb epitopes are in regions of the extracellular domain of the TSH receptor that have no homology in gonadotropin receptors, these data explain at least in part the organ-specific nature of TSH receptor autoantibodies in autoimmune thyroid disease.
|
1349156 |
1992 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Genetics of Thyroid-Stimulating Hormone Receptor-Relevance for Autoimmune Thyroid Disease.
|
28421036 |
2017 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
The TSHR is also a primary antigen in autoimmune thyroid disease, and some TSHR antibodies may activate the receptor, while others inhibit its activation or have no influence on signal transduction at all, depending on how they influence the integrity of the structure.
|
16075037 |
2005 |
Autoimmune thyroid disease
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We compared it with the TBII assay utilizing porcine thyroid membranes expressing porcine TSHR, which has been widely used for TBII assay, by using 96 serum samples from patients with autoimmune thyroid disease and normal individuals.
|
8543557 |
1995 |
Autoimmune thyroid disease
|
0.100 |
Biomarker
|
disease |
BEFREE |
Thyroid stimulatory autoantibodies in different patients with autoimmune thyroid disease do not all recognize the same components of the human thyrotropin receptor: selective role of receptor amino acids Ser25-Glu30.
|
1361193 |
1992 |