|
Neoplasms
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We explored the effects of mtDNA mutations on tumor phenotype employing mtDNA-depleted SK-Hep1 rho0 hepatoma cells.
|
20127020 |
2010 |
|
Vital capacity
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Genome-wide association analyses for lung function and chronic obstructive pulmonary disease identify new loci and potential druggable targets.
|
28166213 |
2017 |
|
Fasting blood glucose measurement
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Fasting blood sugar result
|
0.100 |
GeneticVariation
|
phenotype |
GWASDB |
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways.
|
22885924 |
2012 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
TSP-1 was detected in human hepatocarcinoma SK-HEP-1, Hep 3B and immortalized human liver Chang cells.
|
11216860 |
2001 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The purpose of this study was to screen nimesulide for anticancer activity in chemically induced hepatocellular carcinoma in Wistar rats as well as in BEL 7402 and HEP G2 cell lines.
|
29728874 |
2019 |
|
Adult Liver Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Ras-carrying G12V and Y40C site mutation was transfected into liver cancer cell lines SNU-475 and SK-Hep-1.
|
31642074 |
2020 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Ras-carrying G12V and Y40C site mutation was transfected into liver cancer cell lines SNU-475 and SK-Hep-1.
|
31642074 |
2020 |
|
Malignant neoplasm of liver
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Ras-carrying G12V and Y40C site mutation was transfected into liver cancer cell lines SNU-475 and SK-Hep-1.
|
31642074 |
2020 |
|
TNF receptor-associated periodic fever syndrome (TRAPS)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Transcriptome analysis on 30,000 human genes was performed on SK-Hep-1 human endothelial cells transfected with either wild-type (WT) or TRAPS-associated mutant TNFRI.
|
19116900 |
2009 |
|
Steatohepatitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The values of PKC-ε were the highest in the steatosis groups (HL-7702 cells were 91.10%, SK-HEP-1 cells were 98.20%).
|
30573200 |
2018 |
|
Tumor Necrosis Factor Receptor 1-Associated Periodic Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Transcriptome analysis on 30,000 human genes was performed on SK-Hep-1 human endothelial cells transfected with either wild-type (WT) or TRAPS-associated mutant TNFRI.
|
19116900 |
2009 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In this report, an immunoprecipitate activity assay of protein kinase FA/glycogen synthase kinase-3 alpha (kinase F(A)/GSK-3 alpha) (a member of PDPK family) has been optimized for human hepatoma and used to demonstrate for the first time significantly increased (P < 0.01) activity in poorly differentiated SK-Hep-1 hepatoma (24.2 +/- 2.8 units/mg) and moderately differentiated Mahlavu hepatoma (14.5 +/- 2.2 units/mg) when compared to well differentiated Hep 3B hepatoma (8.0 +/- 2.4 units/mg).
|
9173087 |
1996 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Hepatoma cell lines (BEL-7402 and SK-Hep1) were treated with HBO at 2 atmosphere absolute pressure for 80 min per day or combined with sorafenib or cisplatin.
|
24956259 |
2014 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We show that the human hepatoma line SK-Hep-1 has cytosolic Ah receptor detectable by specific binding of [3H]TCDD.
|
11147830 |
2000 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Lack of CYP1A1 expression is involved in unresponsiveness of the human hepatoma cell line SK-HEP-1 to dioxin.
|
16054781 |
2005 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Using RT-QPCR and Taqman low density arrays we have analyzed biopsies from healthy livers or surgically removed tumors from naive patients and cell lines derived from HCC (SK-HEP-1, Alexander and Huh7), CGC (TFK1) and HPB (HepG2), before and after exposure to cisplatin at IC50 for 72 h. In liver tumors FXR expression was not enhanced but significantly decreased (healthy liver > HCC > HPB ≈ CGC).
|
22524153 |
2012 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Here we showed that PP7 VLPs carrying a CPP penetrated hepatoma SK-HEP-1 cells and delivered the pre-microRNA-23b, which was processed into a mature product within 24 h; a concentration of 10 nM was sufficient for the inhibition of hepatoma cell migration via the downregulation of liver-intestine cadherin expression.
|
28442387 |
2017 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Functional analysis showed that, in vitro, miR-451 inhibited the migration of hepatoma cell lines HepG2 and SK-Hep-1.
|
24968707 |
2014 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We investigated the causes of this low CYP activity by analysing the activity, protein, mRNA and heterologous nuclear RNA contents of the most important CYPs involved in drug metabolism (1A1, 1A2, 2A6, 2B6, 2C9, 2C19, 2D6, 2E1, 3A4, 3A5) in cultured human hepatocytes, and in HepG2 and Mz-Hep-1 hepatoma cell lines.2.
|
12160483 |
2002 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Among 7 hepatoma cell lines analyzed, 5-alpha-fetoprotein (AFP)-producing hepatoma cell lines (HepG2, Huh7, Hep3B, PLC/PRF/5, and Huh6) were shown to have common gene-expression profiles compared with those of AFP-negative hepatoma cell lines (HLE and SK-Hep1) and cancer cell lines of nonhepatocyte origin (HeLa and KMBC).
|
11230749 |
2001 |
|
Liver neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
None of the hepatoma cell lines studied, however, expressed detectable levels of androgen receptor messenger RNA except for the SK-HEP-1 hepatoma cell line.
|
1648543 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In BALB/nude mice, SK-Hep-1 HCC cells pretreated with the 5 microM antisense ODN MZF-1 formed tumors much smaller than the cells with sense ODN.
|
17593797 |
2007 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
The cytocompatibility of G4.0-PAMAM@HEP-mPEG nanocarriers was significantly increased compared with its parentally G4.0-PAMAM dendrimer in both mouse fibroblast NIH3T3 and the human tumor HeLa cell lines.
|
29025661 |
2018 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
SK-HEP-1 flank tumors (n = 24) in athymic mice were treated with HSV10xHRE/sFlk-1.
|
15531234 |
2004 |