|
Acute Cerebrovascular Accidents
|
0.300 |
Therapeutic
|
disease |
CTD_human |
Uncoupling protein-2 prevents neuronal death and diminishes brain dysfunction after stroke and brain trauma.
|
12858170 |
2003 |
|
Acute Chest Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In our study we analysed the association between LTL and five selected variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and rs8053257; UCP2 rs659366 and rs622064), which are not only involved in telomere-length maintenance but also potentially associated with higher risk of acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls).
|
26765095 |
2016 |
|
Acute Coronary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In our study we analysed the association between LTL and five selected variants within three candidate genes (TERC rs12696304; TERF2IP rs3784929 and rs8053257; UCP2 rs659366 and rs622064), which are not only involved in telomere-length maintenance but also potentially associated with higher risk of acute coronary syndrome (ACS) in Czech women (505 cases and 642 controls).
|
26765095 |
2016 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previous studies indicate that mitochondrial uncoupling protein 2 (UCP‑2) is involved in the progression of AMI.
|
28901505 |
2017 |
|
Acute pancreatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Moreover, irisin upregulated UCP2 expression in the pancreas, and administration of genipin, a specific UCP2 antagonist, abolished irisin's beneficial effects in L-arginine-induced AP.
|
31250660 |
2019 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
UCP2 was the most significantly upregulated gene in primary adenocarcinoma cells in the current study.
|
27478826 |
2016 |
|
Adenocarcinoma of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Intriguingly, the autophagy induced by genipin is able to potentiate the autophagic cell death triggered by gemcitabine, the standard chemotherapeutic drug for pancreatic adenocarcinoma, supporting the development of an anti-cancer therapy based on UCP2 inhibition associated to standard chemotherapy.
|
23124112 |
2013 |
|
Adenocarcinoma of pancreas
|
0.020 |
Biomarker
|
disease |
BEFREE |
Altogether, these results reveal novel mechanisms through which UCP2 promotes cancer cell proliferation and support the combined inhibition of UCP2 and of Akt/mTOR pathway as a novel therapeutic strategy in the treatment of pancreatic adenocarcinoma.
|
28962872 |
2017 |
|
Adenoviral infections
|
0.010 |
AlteredExpression
|
group |
BEFREE |
High-glucose exposure reduced EDR in mouse aortae, which was exaggerated in UCP2 knockout (KO) mice, whereas UCP2 overexpression by adenoviral infection (AdUCP2) restored the impaired EDR.
|
22461387 |
2012 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, MiR-30e-UCP2 pathway participates in different stages of ALD and its therapeutic effect on AH may be through influencing oxidative stress and energy metabolism.
|
28969071 |
2017 |
|
Agitation
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Agitation, CTCAE 3.0
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Agitation, CTCAE 5.0
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
alcohol sensitivity
|
0.300 |
Biomarker
|
phenotype |
PSYGENET |
Uncoupling protein 2 (UCP2) lowers alcohol sensitivity and pain threshold.
|
12147287 |
2002 |
|
Alcoholic Liver Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To investigate the expression of miR-30e-UCP2 pathway in different stages of alcoholic liver disease (ALD) and its capacity and mechanism in regulating alcoholic hepatitis (AH) progress.
|
28969071 |
2017 |
|
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Chronic hyperglycemia, independent of plasma lipid levels, is sufficient for the loss of beta-cell differentiation and secretory function in the db/db mouse model of diabetes.
|
16123366 |
2005 |
|
Alloxan Diabetes
|
0.300 |
Biomarker
|
disease |
CTD_human |
Impaired expression of NADH dehydrogenase subunit 1 and PPARgamma coactivator-1 in skeletal muscle of ZDF rats: restoration by troglitazone.
|
14563825 |
2004 |
|
Alzheimer's Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our current results suggest that upregulation of GMF expression is associated with down-regulation of UCP2 as well as UCP4 in the parahippocampal gyrus of AD brains as compared to non-AD brains.
|
28572767 |
2017 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Here, we tested the potential neuroprotective effects of UCP2 and its ability to modulate mitochondrial function, in the G93A mutant SOD1 mouse model of familial ALS.
|
24141050 |
2013 |
|
Amyotrophic Lateral Sclerosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings suggest a novel hypothesis of ALS bioenergetics linking FAO and UCP2.
|
29500423 |
2018 |
|
Anaplastic carcinoma
|
0.300 |
Biomarker
|
disease |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
|
Animal Mammary Neoplasms
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Global gene expression profiling of chemically induced rat mammary gland carcinomas and adenomas.
|
16316942 |
2005 |
|
Anorexia
|
0.010 |
Biomarker
|
disease |
LHGDN |
Uncoupling protein-2/uncoupling protein-3 gene polymorphism is not associated with anorexia nervosa.
|
15564896 |
2004 |
|
Anorexia Nervosa
|
0.030 |
GeneticVariation
|
disease |
LHGDN |
Analysis of microsatellite markers at the UCP2/UCP3 locus on chromosome 11q13 in anorexia nervosa.
|
11920154 |
2002 |
|
Anorexia Nervosa
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Association between a marker in the UCP-2/UCP-3 gene cluster and genetic susceptibility to anorexia nervosa.
|
10089012 |
1999 |