|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
The human Unp gene at 3p21.3 has sequence similarity to ubiquitin proteases and has been suggested to play a role in carcinogenesis of the lung (Gray et al., 1995).
|
9464533 |
1998 |
|
Carcinoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Among genes that were most significantly upregulated in carcinomas were 2 ubiquitin-related genes (USP4 and UFD1L) and several insulinlike growth factor-related genes (IGF2, IGF2R, IGFBP3 and IGFBP6).
|
16360395 |
2005 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
Taken together, the present study provides a novel insight into the regulation of the NF-κB signalling pathway and uncovers a previously unknown function of USP4 in cancer.
|
22029577 |
2012 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Taken together, the present study provides a novel insight into the regulation of the NF-κB signalling pathway and uncovers a previously unknown function of USP4 in cancer.
|
22029577 |
2012 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
Importantly, AKT (also known as protein kinase B), which has been associated with poor prognosis in breast cancer, directly associates with and phosphorylates USP4.
|
22706160 |
2012 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Depletion of USP4 mitigates TGF-β-induced epithelial to mesenchymal transition and metastasis.
|
22706160 |
2012 |
|
Breast Carcinoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Importantly, AKT (also known as protein kinase B), which has been associated with poor prognosis in breast cancer, directly associates with and phosphorylates USP4.
|
22706160 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Therefore, our results indicate that USP4 has tumor suppressor roles in HNSCC and suggest USP4 as a potential therapeutic target for HNSCC.
|
23313255 |
2013 |
|
Squamous cell carcinoma of the head and neck
|
0.010 |
Biomarker
|
disease |
BEFREE |
Therefore, our results indicate that USP4 has tumor suppressor roles in HNSCC and suggest USP4 as a potential therapeutic target for HNSCC.
|
23313255 |
2013 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
In a heterotropic patient-derived HCC xenograft model, USP4 was also overexpressed in G1 and G2 tumors when miR-148a was dysregulated, reflecting the closer link between miR-148a and USP4 for a shift in the expansion phase of tumorgraft.
|
24798342 |
2014 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
microRNA-148a dysregulation discriminates poor prognosis of hepatocellular carcinoma in association with USP4 overexpression.
|
24798342 |
2014 |
|
Rheumatic Heart Disease
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Moreover, USP4 and IL-17 mRNA, but not RORγt mRNA, were significantly elevated in CD4(+) T cells from patients with rheumatic heart disease.
|
25821221 |
2015 |
|
Autoimmune Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Thus, USP4 could be a novel therapeutic target for the treatment of Th17-modulated autoimmune diseases.
|
25821221 |
2015 |
|
Malignant tumor of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Consistent with this correlation, USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.
|
26189775 |
2015 |
|
Colon Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Consistent with this correlation, USP4 knockdown in HCT116, a colon cancer cell line, reduced invasion and migration activity.
|
26189775 |
2015 |
|
Neoplasm Metastasis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of USP4 diminished colorectal cancer cell growth, colony formation, migration, and invasion in vitro and metastasis in vivo.
|
26669864 |
2016 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Ubiquitin specific protease 4 (USP4) is a deubiquitinating enzyme with key roles in the regulation of p53 and TGFβ signaling, suggesting its importance in tumorigenesis.
|
26669864 |
2016 |
|
Malignant Neoplasms
|
0.040 |
Biomarker
|
group |
BEFREE |
However, the mechanisms and regulatory roles of USP4 in cancer, including colorectal cancer, remain largely elusive.
|
26669864 |
2016 |
|
Tumor Cell Invasion
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
Knockdown of USP4 diminished colorectal cancer cell growth, colony formation, migration, and invasion in vitro and metastasis in vivo.
|
26669864 |
2016 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
However, the mechanisms and regulatory roles of USP4 in cancer, including colorectal cancer, remain largely elusive.
|
26669864 |
2016 |
|
Colorectal Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we found that phosphatase of regenerating liver-3 (PRL-3) is indispensable for USP4-mediated oncogenic activity in colorectal cancer.
|
26669864 |
2016 |
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Importantly, we found that phosphatase of regenerating liver-3 (PRL-3) is indispensable for USP4-mediated oncogenic activity in colorectal cancer.
|
26669864 |
2016 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
Biomarker
|
disease |
BEFREE |
Taken together, our results indicate that USP4 is a promising therapeutic target for brain metastasis in patients with lung adenocarcinoma.
|
26883469 |
2016 |
|
Metastatic malignant neoplasm to brain
|
0.010 |
Biomarker
|
disease |
BEFREE |
Using bioluminescence imaging, we found that knockdown of USP4 suppressed brain metastasis in vivo and significantly increased overall survival and brain metastasis-free survival.
|
26883469 |
2016 |
|
Malignant neoplasm of breast
|
0.050 |
Biomarker
|
disease |
BEFREE |
The migration and invasion assays showed that USP4 promotes human breast cancer cell migration and invasion by USP4 overexpression, and knockdown of USP4 by siRNA inhibits human breast cancer cell migration and invasion.
|
27049265 |
2016 |