|
Malignant neoplasm of thyroid
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this article, we investigate the function of UPP1 expression in thyroid cancer.
|
31496029 |
2019 |
|
Giardiasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Four selected proteins, uridine phosphorylase-like protein-1, protein 21.1 (GL50803_27925), α1-giardin, and α11-giardin, were subsequently produced in recombinant form and shown to be immunogenic in mice and <i>G. lamblia</i>-infected humans and confer protection against <i>G. lamblia</i> infection upon intranasal immunization in rodent models of giardiasis.
|
30962402 |
2019 |
|
Septicemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expression of S100a8, Upp1, and Mt2a in all three brain regions of young septic rats indicate that these genes may be involved in the first line of response to sepsis in the younger brain.
|
30706174 |
2019 |
|
Thyroid Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this article, we investigate the function of UPP1 expression in thyroid cancer.
|
31496029 |
2019 |
|
Sepsis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The increased expression of S100a8, Upp1, and Mt2a in all three brain regions of young septic rats indicate that these genes may be involved in the first line of response to sepsis in the younger brain.
|
30706174 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Notably, pyrroline-5-carboxylate reductase 2 (PYCR2) and uridine phosphorylase 1 (UPase1) were found to be altered in ESCC.
|
30559182 |
2019 |
|
Thyroid carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this article, we investigate the function of UPP1 expression in thyroid cancer.
|
31496029 |
2019 |
|
Secondary malignant neoplasm of lymph node
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
UPP1 overexpression was significantly correlated with lymph node metastasis, tumour stage and tumour size.
|
31496029 |
2019 |
|
Colonic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
UPP1-knockout mice have increased intestinal concentrations of uridine and Deoxyuridine triphosphate (dUTP), have increased uridine-induced DNA damage, and develop colon tumors.
|
29964038 |
2018 |
|
Fetal Growth Retardation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Autophagy increases in placenta-related obstetrical diseases such as preeclampsia and intrauterine growth retardation but the regulation of autophagy by ubiquitin proteasome pathway (UPP) proteins, p97/Valosin containing protein (VCP) and ubiquitin (Ub) have not been previuosly studied in preeclampsia.
|
29941173 |
2018 |
|
Tuberculosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
A M. tuberculosis knockout strain for upp gene was generated by allelic replacement.
|
28130366 |
2017 |
|
Adenoma of lung
|
0.010 |
Biomarker
|
disease |
BEFREE |
Multiple tumors (e.g., lymphoma, hepatoma and lung adenoma) occurred simultaneously in some UPase deficient mice, but not in wild-type mice raised under the same conditions.
|
26801745 |
2016 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Targeted disruption (-/-) of murine uridine phosphorylase (UPase) disrupted the homeostasis of uridine and increased spontaneous tumorigenesis by more than 3-fold.
|
26801745 |
2016 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
To investigate whether UPP activated ROS/PARP and NF-κB inflammatory factor pathways in Diabetic Retinopathy, human retinal endothelial cells (HRECs) and rats with streptozotocin-induced diabetes were used to determine the effect of UPP on ROS generation, cell apoptosis, mitochondrial membrane potential (ΔΨm) and inflammatory factor protein expression, through flow cytometry assay, immunohistochemistry, Real-time PCR, Western blot analysis and ELISA.
|
26391545 |
2015 |
|
Diabetic Retinopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
It has been indicated that the pathogenic effect of UPP on DR was involved in the increase of ROS generation and NF-κB expression, which associated with the ROS/PARP and NF-κB inflammatory factor pathways.
|
26391545 |
2015 |
|
Epiretinal Membrane
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Clinical study showed the overexpression of UPP and detachment of epiretinal membranes in proliferative DR (PDR) patients.
|
26391545 |
2015 |
|
Malignant neoplasm of stomach
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU.
|
17214321 |
2007 |
|
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Up-regulated expression of the uridine phosphorylase gene in human gastric tumors is correlated with a favorable prognosis.
|
17214321 |
2007 |
|
Stomach Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data suggest that the paired expression level of the UP gene in gastric cancer is a possible prognostic marker for the patients who received 5-FU.
|
17214321 |
2007 |
|
Toxic Epidermal Necrolysis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we evaluated the correlation between sensitivity to 5-fluorouracil (5-FU) and the mRNA expression level of several 5-FU-related metabolic enzymes [thymidylate synthase, dihydropyrimidine dehydrogenase (DPD), thymidylate phosphorylase (TP), orotate phosphoribosyl transferase, and uridine phosphorylase] in primary colorectal cancer and synchronous liver metastases from ten patients to investigate how colorectal cancer acquires 5-FU resistance during liver metastases.
|
16525674 |
2006 |
|
Adenocarcinoma of large intestine
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The mRNA levels of TS, DPD, OPRT, TP, and UP were measured by real-time quantitative RT-PCR in samples from 23 consecutive patients with both primary colorectal adenocarcinoma and liver metastasis.
|
15060742 |
2004 |
|
Mouth Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Uridine phosphorylase is a potential prognostic factor in patients with oral squamous cell carcinoma.
|
12115385 |
2002 |
|
Neoplasm Metastasis
|
0.010 |
AlteredExpression
|
phenotype |
LHGDN |
High staining of UPase (defined as > 50% of cells in a tumor biopsy that are positive for UPase) in primary tumors frequently was associated with the presence of metastasis to lymph nodes (P = 0.007 by the Fischer exact test) and with lower overall survival (P = 0.03 by the log-rank test).
|
12115385 |
2002 |
|
Solid Neoplasm
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
The expression levels of UPase and dThdPase are higher in human solid tumors including breast carcinomas than in normal tissues.
|
11807789 |
2002 |