Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Our observations suggest that VEGF expression could be used as a prognostic marker in early-stage prostate tumors, whereas neuropilin-1 overexpression might be a marker of aggressiveness.
|
10754495 |
2000 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
MMAC/PTEN tumor suppressor gene regulates vascular endothelial growth factor-mediated angiogenesis in prostate cancer.
|
12168088 |
2002 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Vascular endothelial growth factor and signaling in the prostate: more than angiogenesis.
|
12039075 |
2002 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
We have coupled two of these therapeutic approaches, gene therapy and antiangiogenic therapy and tested them in two murine prostate cancer models Recombinant adenovirus encoding the ligand-binding ectodomain of the VEGF receptor 2 (Flk1) fused to an Fc domain was administered to SCID mice carrying orthotopic human LNCaP tumors as well as to transgenic (TRAMP) mice with spontaneous prostate tumors.
|
12496487 |
2003 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Bombesin stimulates nuclear factor kappa B activation and expression of proangiogenic factors in prostate cancer cells.
|
12839933 |
2003 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for prostate cancer.
|
12893367 |
2003 |
Prostatic Neoplasms
|
0.400 |
GeneticVariation
|
group |
LHGDN |
Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for prostate cancer.
|
12893367 |
2003 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
The androgen receptor is significantly associated with vascular endothelial growth factor and hypoxia sensing via hypoxia-inducible factors HIF-1a, HIF-2a, and the prolyl hydroxylases in human prostate cancer.
|
16278385 |
2005 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Vascular endothelial growth factor (VEGF), its receptors (VEGFRs), and alpha5beta1 integrin were expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor.
|
15500293 |
2005 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Vascular endothelial growth factor (VEGF), its receptors (VEGFRs), and alpha5beta1 integrin were expressed by prostate cancer cells in vitro and by prostate tumors in vivo, and their expression was elevated at sites of bone metastasis compared to original prostate tumor.
|
15500293 |
2005 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Stage-specific characterization of the vascular endothelial growth factor axis in prostate cancer: expression of lymphangiogenic markers is associated with advanced-stage disease.
|
15701844 |
2005 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Overexpression of Id-1 in prostate cancer cells promotes angiogenesis through the activation of vascular endothelial growth factor (VEGF).
|
15905202 |
2005 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
A role for cyclin A1 in mediating the autocrine expression of vascular endothelial growth factor in prostate cancer.
|
16007189 |
2005 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interleukin 8 (IL-8) and vascular endothelial growth factor (VEGF) are two cytokines promoting prostate tumor growth and angiogenesis.
|
16530725 |
2006 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Association of VEGF genetic polymorphisms with prostate carcinoma risk and clinical outcome.
|
16908180 |
2006 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
Diverse effects of zinc on NF-kappaB and AP-1 transcription factors: implications for prostate cancer progression.
|
16606632 |
2006 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Expression analysis of peptide growth factors VEGF, FGF2, TGFB1, EGF and IGF1 in prostate cancer and benign prostatic hyperplasia.
|
16820871 |
2006 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Hypoxia increases VEGF-A production by prostate cancer and bone marrow stromal cells and initiates paracrine activation of bone marrow endothelial cells.
|
16826426 |
2006 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Prostate tumors showed a significant increase in the percentage of VEGF(121) and decreases in VEGF(165) (p < 0.01) and VEGF(189) (p < 0.05).
|
17278099 |
2007 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
These observations support the hypothesis that genistein may inhibit prostate tumor angiogenesis through the suppression of VEGF-mediated autocrine and paracrine signaling pathways between tumor cells and vascular endothelial cells.
|
17142033 |
2007 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Plasma levels and expression of vascular endothelial growth factor-A in human localized prostate cancer.
|
17549360 |
2007 |
Prostatic Neoplasms
|
0.400 |
AlteredExpression
|
group |
LHGDN |
Depletion of intracellular zinc increases expression of tumorigenic cytokines VEGF, IL-6 and IL-8 in prostate cancer cells via NF-kappaB-dependent pathway.
|
18615482 |
2008 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
A statistically significant correlation between expression of cyclin A1 and of MMP2, MMP9, and VEGF was observed in prostate tumors from 482 patients (P values from Spearman rank correlation tests < .001).
|
18612129 |
2008 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Human telomerase reverse transcriptase expression correlates with vascular endothelial growth factor-promoted tumor cell proliferation in prostate cancer.
|
18437586 |
2008 |
Prostatic Neoplasms
|
0.400 |
Biomarker
|
group |
LHGDN |
Inhibition of HIF-1 alpha and VEGF expression by the chemopreventive bioflavonoid apigenin is accompanied by Akt inhibition in human prostate carcinoma PC3-M cells.
|
18240292 |
2008 |