Malignant neoplasm of kidney
|
0.700 |
GenomicAlterations
|
disease |
CGI |
|
|
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
|
|
|
Malignant neoplasm of kidney
|
0.700 |
CausalMutation
|
disease |
CGI |
|
|
|
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The VHL gene is a powerful tool for the study of the biology and diagnosis of kidney cancer.
|
7754256 |
1995 |
Malignant neoplasm of kidney
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
The VHL tumour-suppressor gene (TSG) has a critical 'gatekeeper' role in regulating growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer.
|
9820032 |
1998 |
Malignant neoplasm of kidney
|
0.700 |
PosttranslationalModification
|
disease |
BEFREE |
pVHL, the product of the VHL tumor suppressor gene, plays an important role in the regulation of cell growth and differentiation of human kidney cells, and inactivation of the VHL gene is the most frequent genetic event in human kidney cancer.
|
10421634 |
1999 |
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
In this study, we collected 35 archived Swedish sporadic RCCs identified from an epidemiological study on occupational exposure and kidney cancer to test how well stored pathological specimens could be retrieved and analyzed for VHL mutations.
|
10454237 |
1999 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
Recent identification of VHL, c-met and TSC as candidate genes mutated in various types of renal carcinomas has greatly enhanced our understanding of the pathogenesis of renal carcinomas and has provided novel therapeutic options for patients with renal cancer.
|
11753085 |
2002 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
CTD_human |
Down-regulation of von Hippel-Lindau protein in N-nitroso compound-induced rat non-clear cell renal tumors.
|
11880179 |
2002 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The TRC8 hereditary kidney cancer gene suppresses growth and functions with VHL in a common pathway.
|
12032852 |
2002 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
In conclusion, unlike other hereditary kidney cancer-related genes (i.e., VHL and MET), which are cell type-specific, BHD is involved in the entire spectrum of histological types of renal tumors, suggesting its major role in kidney cancer tumorigenesis.
|
12907635 |
2003 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
In addition to VHL, which is associated with clear cell carcinoma, one can now list HPRC (associated with type I papillary renal cancer) and HLRCC (associated with type II papillary renal cancer).
|
14521208 |
2003 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
This review summarizes the current knowledge of the molecular pathogenesis of von Hippel-Lindau disease and the role of the VHL gene product (pVHL) in kidney cancer and the mammalian oxygen sensing pathway.
|
14569079 |
2003 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The von Hippel-Lindau (VHL) gene is the major renal cancer gene in adults.
|
14973063 |
2004 |
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
VHL mutations in renal cell cancer: does occupational exposure to trichloroethylene make a difference?
|
15177666 |
2004 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The von Hippel-Lindau tumor suppressor gene and kidney cancer.
|
15448019 |
2004 |
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Genetic and epigenetic analysis of von Hippel-Lindau (VHL) gene alterations and relationship with clinical variables in sporadic renal cancer.
|
16488999 |
2006 |
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
The von Hippel-Lindau tumor suppressor protein (pVHL) is frequently mutated in kidney cancer and is part of the ubiquitin ligase complex that targets prolyl hydroxylated HIFalpha for destruction.
|
17220275 |
2007 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
Most of what is known about the genetic basis of kidney cancer has been learned from study of the inherited forms of kidney cancer: von Hippel Lindau (VHL gene), hereditary papillary renal carcinoma (c-Met gene), Birt Hogg Dubé (BHD gene), and hereditary leiomyomatosis renal cell cancer (fumarate hydratase gene).
|
17255292 |
2007 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The VHL gene product, pVHL, has multiple functions, but the best documented, and the one most clearly linked to tumor development, relates to its role as the substrate recognition module of a ubiquitin ligase complex that targets hypoxia-inducible factor (HIF) for destruction. pVHL function is often compromised in sporadic kidney cancers, and inhibitors of the HIF-responsive growth factor (vascular endothelial growth factor) are active against this disease. pVHL, by inhibiting atypical protein kinase C and hence JunB, also affects neuronal survival, as do the products of the other genes linked to familial pheochromocytoma or paraganglioma (NF1, RET, SDHB, SDHC, and SDHD).
|
18039096 |
2007 |
Malignant neoplasm of kidney
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Clear-cell renal cell carcinoma (RCC) is the most prevalent form of kidney cancer and is frequently associated with loss of von Hippel-Lindau (VHL) gene function, resulting in the aberrant transcriptional activation of genes that contribute to tumor growth and metastasis, including transforming growth factor-alpha (TGF-alpha), a ligand of the epidermal growth factor receptor (EGFR) tyrosine kinase.
|
18243508 |
2008 |
Malignant neoplasm of kidney
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Loss of VHL function causes the overexpression of transforming growth factor (TGF)-alpha, leading us to hypothesize that TGF-alpha could be a potential TAA for immunotherapy of kidney cancer, which was evaluated in this study.
|
19052740 |
2009 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
We investigated whether alcohol is associated with (epi)genetic changes of the von Hippel-Lindau (VHL) gene in renal cell cancer.
|
19064569 |
2008 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
The VHL gene is the gene for the hereditary cancer syndrome, von Hippel-Lindau, as well as for the common form of sporadic, noninherited, clear cell kidney cancer.
|
19402075 |
2009 |
Malignant neoplasm of kidney
|
0.700 |
Biomarker
|
disease |
BEFREE |
VHL is the gene for clear cell kidney cancer.
|
20059341 |
2010 |