|
Carcinoma, Lobular
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Patients with ILC had higher VWF RNA expression than patients with infiltrating ductal carcinoma and other histology.
|
31018945 |
2019 |
|
alpha 1-Antitrypsin Deficiency
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In particular, non-random occurrence was revealed for SERPINA1 c.1096G > A (alpha-1 antitrypsin deficiency), C8B c.1282C > T and c.1653G > A (complement component 8B deficiency), ATP7B c.3207C > A (Wilson disease), PROP1 c.301_302delAG (combined pituitary hormone deficiency), CYP21A2 c.844G > T (non-classical form of adrenogenital syndrome), EYS c.1155T > A (retinitis pigmentosa), HADHA c.1528G > C (LCHAD deficiency), SCO2 c.418G > A (cytochrome c oxidase deficiency), OTOA c.2359G > T (sensorineural deafness), C2 c.839_866del (complement component 2 deficiency), ACADVL c.848T > C (VLCAD deficiency), TGM5 c.337G > T (acral peeling skin syndrome) and VWF c.2561 G > A (von Willebrand disease, type 2N).
|
31028847 |
2019 |
|
Hallucinations, Visual
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
We used biochemical methods to assess microvessel density (level of von Willebrand factor, a marker of endothelial cell content), ante-mortem oxygenation (vascular endothelial growth factor, a marker of tissue hypoxia; myelin-associated glycoprotein to proteolipid protein-1 ratio, a measure of tissue oxygenation relative to metabolic demand), cholinergic innervation (acetylcholinesterase and choline acetyltransferase), butyrylcholinesterase and insoluble α-synuclein content in the BA18 and BA19 occipital cortex obtained post-mortem from 23 AD patients who had experienced visual hallucinations, 19 AD patients without hallucinations, 19 DLB patients, and 36 controls.
|
31511061 |
2019 |
|
Neurologic Symptoms
|
0.010 |
Biomarker
|
group |
BEFREE |
Statistical analysis showed that loss of VWF-HMWM as assessed by VWF:CB < 70 IU/dL is associated with detectable anti-ADAMTS13 antibodies, severe neurological symptoms and thrombocytopenia (p < 0.05).
|
31330376 |
2019 |
|
acute aortic dissection
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
This report showed that patients with acute aortic dissection had increased levels of VWF:GPIbM before surgery that decreased slightly during surgery.
|
31030033 |
2019 |
|
Mitral and aortic incompetence
|
0.010 |
Biomarker
|
disease |
BEFREE |
Loss of the highest-molecular-weight multimers of VWF and bleeding also have been described in subaortic stenosis in hypertrophic cardiomyopathy, in isolated mitral and aortic insufficiency, in endocarditis, in patients with prosthetic valve stenosis or regurgitation, and in patients with left ventricular assist devices (LVADs).
|
31230737 |
2019 |
|
Pancreatitis, Acute Necrotizing
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Lungs from the ANP mice showed increased expression of IL-6, IL-10, monocyte chemoattractant protein 1 (MCP-1) and von Willebrand factor compared to those from the controls.
|
31037357 |
2019 |
|
Exocrine pancreatic insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, while the effect of the <i>ABO</i> locus on Col-Epi phenotype is mediated through VWF and/or FVIII, the effect of the <i>ABO</i> locus on Col-ADP phenotype is partly produced through VWF and/or FVIII, and partly through other mechanisms.
|
31262040 |
2019 |
|
Factor 8 deficiency, acquired
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
They are more commonly directed against factor VIII (FVIII) or von Willebrand factor leading to acquired hemophilia A or acquired von Willebrand syndrome, respectively.
|
31808848 |
2019 |
|
Adult Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation of Preoperative Von Willebrand Factor with Magnetic Resonance Imaging Perfusion and Permeability Parameters as Predictors of Prognosis in Glioblastoma.
|
30312827 |
2019 |
|
Childhood Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation of Preoperative Von Willebrand Factor with Magnetic Resonance Imaging Perfusion and Permeability Parameters as Predictors of Prognosis in Glioblastoma.
|
30312827 |
2019 |
|
Adrenogenital Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In particular, non-random occurrence was revealed for SERPINA1 c.1096G > A (alpha-1 antitrypsin deficiency), C8B c.1282C > T and c.1653G > A (complement component 8B deficiency), ATP7B c.3207C > A (Wilson disease), PROP1 c.301_302delAG (combined pituitary hormone deficiency), CYP21A2 c.844G > T (non-classical form of adrenogenital syndrome), EYS c.1155T > A (retinitis pigmentosa), HADHA c.1528G > C (LCHAD deficiency), SCO2 c.418G > A (cytochrome c oxidase deficiency), OTOA c.2359G > T (sensorineural deafness), C2 c.839_866del (complement component 2 deficiency), ACADVL c.848T > C (VLCAD deficiency), TGM5 c.337G > T (acral peeling skin syndrome) and VWF c.2561 G > A (von Willebrand disease, type 2N).
|
31028847 |
2019 |
|
Amputated structure (morphologic abnormality)
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
<i>Columba livia</i> (pigeon) ADAMTS13 (pADAMTS13) resembles human delT3-6, retains normal activation by VWF D4, and has a SAXS envelope consistent with amputation of the hairpin containing the dispensable T domains of human ADAMTS13.
|
30692120 |
2019 |
|
Stable angina
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Serum PTX-3, vWf and CXCL13 levels were significantly higher in USAP group than those in either SAP or control groups (p˂0.001).
|
31066256 |
2019 |
|
Chronic liver disease
|
0.010 |
Biomarker
|
group |
BEFREE |
Systematic review: role of elevated plasma von-Willebrand factor as predictor of mortality in patients with chronic liver disease.
|
31498279 |
2019 |
|
Endometriosis of uterus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The staining level of vWF and two pro-angiogenic markers (NF-κB nuclear p65 and TF) correlated with AUB in patients with adenomyosis.
|
31504506 |
2019 |
|
Overlap syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The expression levels of CD31 and VWF in alveolar wall cells in the OS group were lower than those in the OS+BMSC group.
|
31702032 |
2019 |
|
Developmental delay (disorder)
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
We describe a patient with a novel homozygous likely pathogenic missense variant c.1079A>C (p.Tyr360Ser) who presents with chronically low Factor VIII (FVIII) and von Willebrand Factor (vWF) levels and activities in addition to the previously reported symptoms of developmental delay and seizures.
|
30701557 |
2019 |
|
Aortic valve calcification
|
0.010 |
Biomarker
|
disease |
BEFREE |
After adjusting for cardiac risk factors, AVC progression was not independently associated with decreasing FMD% or increasing biomarkers [OR FMD% 1.105 (0.835, 1.463), CRP 1.014 (0.849, 1.210), vWF% 1.132 (0.559, 2.292), PAI 1.124 (0.960, 1.316), fibrinogen 0.909 (0.338, 2.443), IL6 1.061 (0.772, 1.459), E-selectin 0.794 (0.426, 1.480) and ICAM-1 0.998 (0.476, 2.092)].
|
30529828 |
2019 |
|
Sleep Apnea, Obstructive
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We found VWF rs1063856 (OR = 1.50, 95% CIs = 1.10-2.04; p = 0.010), IL-6 rs1800796 (OR = 1.32, 95% CIs = 1.11-1.56; p = 0.002), TNF rs1800629 (OR = 1.44, 95% CIs = 1.13-1.83; p = 0.003), and CRP rs2794521 (OR = 1.27, 95% CIs = 1.04-1.55; p = 0.021) were all significantly associated with increased susceptibility of OSA, while VWF rs1063856 (OR = 1.75, 95% CIs = 1.18-2.62; p = 0.006), IL-6 rs1800796 (OR = 1.39, 95% CIs = 1.10-1.76; p = 0.006) were associated with the severity of OSA.
|
31210414 |
2019 |
|
Global developmental delay
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We describe a patient with a novel homozygous likely pathogenic missense variant c.1079A>C (p.Tyr360Ser) who presents with chronically low Factor VIII (FVIII) and von Willebrand Factor (vWF) levels and activities in addition to the previously reported symptoms of developmental delay and seizures.
|
30701557 |
2019 |
|
Dissection of proximal aorta
|
0.010 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to analyze VWF activity (VWF:GPIbM) and thus the potential of Factor (F) VIII/VWF concentrate as a treatment for refractory bleeding in surgery for acute type A aortic dissection.
|
31030033 |
2019 |
|
Vascular Hemostatic Disorders
|
0.010 |
GeneticVariation
|
group |
BEFREE |
These cause excessive cleavage of VWF multimers resulting in a loss of HMW multimers, known as acquired von Willebrand syndrome (AVWS), a hemostatic disorder similar to VWD type 2A.
|
30867356 |
2019 |
|
Progressive Neoplastic Disease
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In contrast, VWF:Ag and the VWF:Ag/ADAMTS13:AC ratio were significantly lower in patients with SD, PR, and CR than in those with PD (<i>P <</i> 0.05 for both).
|
31139312 |
2019 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
For newly-diagnosed breast cancer, the association between VWF and histology in the GDC Breast Cancer dataset in The Cancer Genome Atlas (TCGA) was evaluated.
|
31018945 |
2019 |