WT1, WT1 transcription factor, 7490

N. diseases: 446; N. variants: 61
Disease: Nephroblastoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease HPO
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 CausalMutation disease CGI
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 SusceptibilityMutation disease ORPHANET
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease GENOMICS_ENGLAND
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 SomaticCausalMutation disease ORPHANET
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GenomicAlterations disease CGI
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease BEFREE On the basis of accumulating data, the recently isolated WT1 gene is a Wilms' tumor gene and a putative tumor suppressor gene. 1311774 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease BEFREE These findings show new aspects of the role of the WT1 gene in the development of Wilms' tumor. 1314024 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Inactivation of the remaining allele of the WT1 gene in a Wilms' tumour from a WAGR patient. 1314370 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease UNIPROT The detection of one nonsense point mutation and one missense WT1 gene point mutation adds to the accumulating evidence implicating this gene in a proportion of Wilms tumor patients. 1317572 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE The detection of one nonsense point mutation and one missense WT1 gene point mutation adds to the accumulating evidence implicating this gene in a proportion of Wilms tumor patients. 1317572 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Modulation of DNA binding specificity by alternative splicing of the Wilms tumor wt1 gene transcript. 1321494 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Identification of the cellular protein encoded by the human Wilms' tumor (WT1) gene. 1334252 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Fluorescence in situ hybridization (FISH) with biotin-labeled probes mapping to 11p13 has been used for the molecular analysis of deletions of the WAGR (Wilms tumor, aniridia, genitourinary abnormalities, and mental retardation) locus. 1334370 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Intragenic homozygous deletion of the WT1 gene in Wilms' tumor. 1350671 1992
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease BEFREE The WT-33 Wilms' tumor candidate gene maps to this deleted segment. 1648959 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE We now report constitutional mutations within the WT1 genes of two individuals with a combination of WT and genital abnormalities as evidence of a role for a recessive oncogene in mammalian development. 1654525 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease BEFREE The wt1 gene, a putative tumor suppressor gene located at the Wilms tumor (WT) locus on chromosome 11p13, encodes a zinc finger-containing protein that binds to the same DNA sequence as EGR-1, a mitogen-inducible immediate-early gene product that activates transcription. 1654597 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Familial predisposition to Wilms tumor does not segregate with the WT1 gene. 1655633 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease BEFREE These antisera should be useful in characterizing the structure and function of the WT1 protein in human Wilms' tumor specimens. 1662794 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 Biomarker disease BEFREE Two similar candidate WT cDNA clones (WT33 and LK15) have recently been identified on the basis of both their expression in fetal kidney and their location within the smallest region of overlap of somatic 11p13 deletions in some tumors. 1673293 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Two of these features are also seen in the WAGR (Wilms' tumour, aniridia, genito-urinary abnormalities, mental retardation) complex, known to be associated with deletions of chromosome region 11p13. 1849870 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 PosttranslationalModification disease BEFREE Structural rearrangements of the WT1 gene in Wilms' tumour cells. 1851548 1991
CUI: C0027708
Disease: Nephroblastoma
Nephroblastoma 		0.800 GeneticVariation disease BEFREE Complete physical map of the WAGR region of 11p13 localizes a candidate Wilms' tumor gene. 2154334 1990