|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The nuclear WT1 protein can be found in blasts of approximately 50-60% of acute leukemia patients at diagnosis.
|
10674900 |
2000 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A high expression of Wilms tumor 1 (WT1) mRNA occurs in most cases of acute leukemia and myelodysplastic syndrome (MDS).
|
27866185 |
2017 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Wilms' tumor (WT1) gene mutations were detected in patients with most forms of acute leukemia.
|
24074521 |
2014 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this regard, many studies have identified WT1 protein as a tumor antigen, considered a target molecule for clinical application in human acute leukemias.
|
27466479 |
2016 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Using semiquantitative RT-PCR, we investigated the expression of the WT-1 gene in peripheral bloods (PBs) of 33 patients with acute leukemia (AML 26; ALL 7) and monitored its expression after achievement of CR.
|
9339129 |
1997 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Positive immunostaining of WT1 was observed only in the portion of acute leukemia and overt leukemia (OL) transformed from MDS with a high WT1 message level, suggesting the relatively high detection threshold of WT1 protein with the immunostaining method.
|
17803653 |
2007 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The tumor suppressor gene wt1 (Wilms tumor 1) encodes a zinc finger transcription factor reported to be expressed in many tumors, including mesotheliomas, carcinomas, and acute leukemias.
|
15894924 |
2005 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
WT1 protein expression in childhood acute leukemia.
|
18161786 |
2008 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Recent observations in adult patients with acute leukaemia suggest that wt1 gene expression is a poor prognostic factor.
|
10480287 |
1999 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Clear correlation was observed between the relative levels of WT1 gene expression (< 0.6 v > or = 0.6) and the prognosis for acute leukemia (AML, ALL, and AMLL).
|
7949179 |
1994 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Prognostic significance of quantitative analysis of WT1 gene transcripts by competitive reverse transcription polymerase chain reaction in acute leukaemia.
|
14510942 |
2003 |
|
Acute leukemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was assessment of WT1 gene expression in patients with acute leukemia, measurement of IL-12 and C3 levels in serum and evaluation of the relationship between them.
|
26514528 |
2015 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
Wilms' tumor gene 1 (WT1) gene expression was analyzed in 32 patient with acute myeloid leukemia (AML) and 18 with acute lymphoblastic leukemia (ALL) to investigate whether it could serve as a MRD marker.
|
19811333 |
2009 |
|
Acute lymphocytic leukemia
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
We studied BM/PB samples from 107 acute myeloid leukaemia (AML) patients and 22 acute lymphoblastic leukaemia (ALL) patients at presentation and detected the WT1 gene in > 90% of patients by a qualitative assay.
|
14510942 |
2003 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Prognostic implications of mutations and expression of the Wilms tumor 1 (WT1) gene in adult acute T-lymphoblastic leukemia.
|
20435628 |
2010 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Graft-versus-leukemia effects associated with detectable Wilms tumor-1 specific T lymphocytes after allogeneic stem-cell transplantation for acute lymphoblastic leukemia.
|
17505014 |
2007 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to examine relative levels of WT1 gene expression (defined in K562 cells as 1.00) in 45 patients with acute myelogenous leukemia (AML), 22 with acute lymphocytic leukemia (ALL), 6 with acute mixed lineage leukemia (AMLL), 23 with chronic myelogenous leukemia (CML), and 24 with non-Hodgkin's lymphoma.
|
7949179 |
1994 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
By contrast, 40 primary samples of acute lymphoblastic leukemia (ALL; B-ALL, n = 15 and T-ALL, n = 10) and acute myeloid leukemia (n = 15) expressed low levels of WT1 protein.
|
18161786 |
2008 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
We have therefore investigated bone marrow samples from 50 children with acute lymphocytic leukaemia at the time of diagnosis for the presence of wt1 transcripts to determine whether wt1 gene expression is associated with specific characteristics of leukaemic cells and whether it is predictive of response to treatment.
|
10480287 |
1999 |
|
Acute lymphocytic leukemia
|
0.090 |
AlteredExpression
|
disease |
BEFREE |
The WT1 gene is considered to be highly expressed in patients with acute myeloid leukemia (AML), acute lymphoblastic leukemia and chronic myeloid leukemia and is thought to play a key role in maintaining the viability of leukemia cells.
|
15182334 |
2004 |
|
Acute lymphocytic leukemia
|
0.090 |
Biomarker
|
disease |
BEFREE |
Wilms tumor 1 (WT1) is a pan-leukemic marker used for identification of the leukemic clone rather than the use of individual specific molecular aberration of ALL.
|
21804407 |
2011 |
|
Acute monocytic leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
The single nucleotide polymorphism (SNP) rs16754 of the WT1 gene has been previously described as a possible prognostic marker in normal karyotype acute myeloid leukemia (AML) patients.
|
23070125 |
2012 |
|
Acute monocytic leukemia
|
0.060 |
AlteredExpression
|
disease |
BEFREE |
High prognostic value of pre-allogeneic stem cell transplantation minimal residual disease detection by WT1 gene expression in AML transplanted in cytologic complete remission.
|
29096332 |
2017 |
|
Acute monocytic leukemia
|
0.060 |
Biomarker
|
disease |
BEFREE |
MN, PNET, CCSK and AML were negative for WT1.
|
27748279 |
2016 |
|
Acute monocytic leukemia
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Wilms tumor 1 (WT1) mutations have recently been identified in approximately 10% of adult acute myeloid leukemia (AML) with normal cytogenetics (CN-AML) and are associated with poor outcome.
|
19171881 |
2009 |