melanoma
|
0.500 |
CausalMutation
|
disease |
CGI |
|
|
|
melanoma
|
0.500 |
Biomarker
|
disease |
HPO |
|
|
|
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role of three polymorphic alleles of the DNA repair gene XPC in a hospital-based case-control study of 294 Caucasian patients from Germany who had cutaneous melanoma and 375 healthy cancer-free sex-matched Caucasian control subjects from the same area.
|
15731165 |
2005 |
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We investigated the role of three variant alleles of the DNA repair gene XPC and one variant allele of the XPG gene in a hospital-based case-control study of 294 Caucasian patients from Germany with malignant melanoma and 375 healthy control individuals from the same area matched by sex.
|
15494739 |
2005 |
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
ORs for XPD and XPC genotypes were stronger for melanoma diagnosed at an early age, but tests for interaction were not statistically significant.
|
16258177 |
2006 |
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Melanoma risk was higher in individuals carrying the complete XPC haplotype than each individual polymorphism (OR 3.64; 95% CI 1.77-7.48).
|
21733660 |
2011 |
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Loss of ARF sensitizes transgenic BRAFV600E mice to UV-induced melanoma via suppression of XPC.
|
23650282 |
2013 |
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Assessment of the XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro) and GSTP1 (Ile105Val) polymorphisms in the risk of cutaneous melanoma.
|
23568549 |
2013 |
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
Severe XPA and XPC cause innumerable carcinomas and melanomas in light-exposed eyes and skin, and enhanced risk of visceral cancers.
|
23622385 |
2013 |
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In addition, there was some evidence of publication bias in the meta-analysis, and meta-analyses of the studies with large sample size did not find the obvious association between XPC Lys939Gln polymorphism and cutaneous melanoma risk in Caucasians.
|
24277375 |
2014 |
melanoma
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Expression of GGR components XPC, DDB1 and DDB2 was significantly lower in melanoma after UVB.
|
27487145 |
2016 |
melanoma
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
XPC (A2920C), XPF (T30028C), TP53 (Arg72Pro), and GSTP1 (Ile105Val) polymorphisms in prognosis of cutaneous melanoma.
|
26427666 |
2016 |
melanoma
|
0.500 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the role of methylation in reduced XPC in melanoma.
|
29373959 |
2018 |