|
Chronic Lymphocytic Leukemia
|
0.440 |
CausalMutation
|
disease |
CGI |
|
|
|
|
Carcinoma
|
0.030 |
Biomarker
|
group |
BEFREE |
These results suggest that EXP1 and/or EXP2/Cyclin D1 may play an important role in the progression of human esophageal carcinomas.
|
8250909 |
1993 |
|
Malaria
|
0.020 |
Biomarker
|
disease |
BEFREE |
CTL were also identified to an additional P. falciparum antigen, exported protein 1 (Exp-1), the homologue of which is a protective antigen in a rodent model of malaria.
|
10603392 |
2000 |
|
Hepatocarcinogenesis
|
0.030 |
Biomarker
|
disease |
BEFREE |
We suggest that Crm1 may play a role in HBx-mediated liver carcinogenesis.
|
11287420 |
2001 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
Interaction of the hepatitis B virus X protein with the Crm1-dependent nuclear export pathway.
|
11287420 |
2001 |
|
Chronic active hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Abnormal cytoplasmic sequestration of Crm1, accompanied by a nuclear localization of NFkappaB, was also observed in hepatocytes from HBV-positive liver samples with chronic active hepatitis.
|
11287420 |
2001 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
We demonstrate the direct interaction of APC-(129-250) with the nuclear export factor chromosome maintenance region 1 (Crm-1).
|
12070164 |
2002 |
|
Carcinogenesis
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
Based on this evidence, we suggest that Crm1 is actively involved in maintaining centrosome integrity and that HBx disrupts this process by inactivating Crm1 and thus contributes to HBV-mediated carcinogenesis.
|
12861014 |
2003 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
BEFREE |
Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.
|
12861014 |
2003 |
|
Hepatitis B
|
0.020 |
Biomarker
|
disease |
LHGDN |
Involvement of Crm1 in hepatitis B virus X protein-induced aberrant centriole replication and abnormal mitotic spindles.
|
12861014 |
2003 |
|
Malaria
|
0.020 |
Biomarker
|
disease |
BEFREE |
The DNA from the whole blood of a malaria patient was used as template to amplify the coding regions for the antigenic domains of circumsporozoite protein (CSP-1), merozoite surface protein (MSP-1), apical merozoite antigen (AMA-1), serine repeat antigen (SERA), and exported antigen (EXP-1).
|
14699261 |
2003 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In addition to the tumor cell-specific nuclear targeting signal, comprising two stretches of basic amino acids in the VP3 COOH terminus which are highly efficient in tumor but not in normal cells, we define the CRM1-recognized nuclear export sequence (NES) within the VP3 tumor cell-specific nuclear targeting signal for the first time.
|
16103052 |
2005 |
|
Hepatocarcinogenesis
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
|
16317707 |
2005 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Marked upregulation of P16(INK4A) was associated with moderate overexpression of HSP90, CDC37, E2F4, and CRM1 in human hepatocellular carcinomas with a better prognosis.
|
16317707 |
2005 |
|
Adenomatous Polyposis Coli
|
0.020 |
Biomarker
|
disease |
BEFREE |
Fractionation showed that wild-type and truncated APC from colon cancer cells were primarily cytoplasmic, but increased in the nucleus after leptomycin B treatment, consistent with CRM1-dependent nuclear export.
|
15678162 |
2005 |
|
Adult Liver Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
|
16317707 |
2005 |
|
Liver and Intrahepatic Biliary Tract Carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
|
16317707 |
2005 |
|
Malignant neoplasm of liver
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Role of HSP90, CDC37, and CRM1 as modulators of P16(INK4A) activity in rat liver carcinogenesis and human liver cancer.
|
16317707 |
2005 |
|
Malignant tumor of colon
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fractionation showed that wild-type and truncated APC from colon cancer cells were primarily cytoplasmic, but increased in the nucleus after leptomycin B treatment, consistent with CRM1-dependent nuclear export.
|
15678162 |
2005 |
|
Fanconi Anemia
|
0.010 |
Biomarker
|
disease |
LHGDN |
Identification of multiple nuclear export sequences in Fanconi anemia group A protein that contribute to CRM1-dependent nuclear export.
|
15790592 |
2005 |
|
Colon Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Fractionation showed that wild-type and truncated APC from colon cancer cells were primarily cytoplasmic, but increased in the nucleus after leptomycin B treatment, consistent with CRM1-dependent nuclear export.
|
15678162 |
2005 |
|
Liver carcinoma
|
0.030 |
Biomarker
|
disease |
BEFREE |
Resistance to HCC is associated with lower genomic instability and downregulation of cell cycle key genes in preneoplastic and neoplastic lesions. p16(INK4A) upregulation occurs in susceptible and resistant rat lesions. p16(INK4A)-induced growth restraint was circumvented by Hsp90/Cdc37 chaperons and E2f4 nuclear export by Crm1 in susceptible, but not in resistant rats and human HCCs with better prognosis.
|
16216419 |
2006 |
|
HTLV-I Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
These observations will enable us to construct a transgenic rat model expressing human CRM1 that is sensitive to HTLV-1 infection.
|
16504563 |
2006 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
CRM1, an RNA transporter, is a major species-specific restriction factor of human T cell leukemia virus type 1 (HTLV-1) in rat cells.
|
16504563 |
2006 |
|
HTLV-I Infections
|
0.020 |
Biomarker
|
group |
BEFREE |
To develop a better animal model for the investigation of HTLV-1 infection, we established a transgenic (Tg) rat carrying the human CRM1 (hCRM1) gene, which encodes a viral RNA transporter that is a species-specific restriction factor.
|
17360758 |
2007 |