Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results of the present meta-analysis have indicated that the XRCC1 codon 399 Gln allele might act as a recessive allele in its association with prostate cancer risk in Asians only.
|
19428062 |
2009 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype of XRCC1 also associated with significant risk for PCa and BC.
|
22019847 |
2012 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association between XRCC1-Arg280His and prostate cancer risk was found under a heterozygote model and a dominant model [corrected].
|
25927275 |
2015 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association of single nucleotide polymorphisms in SOD2, XRCC1 and XRCC3 with susceptibility for the development of adverse effects resulting from radiotherapy for prostate cancer.
|
18582155 |
2008 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in hOGG1 and XRCC1 and risk of prostate cancer: effects modified by plasma antioxidants.
|
19914697 |
2010 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Base excision repair genes XRCC1 and APEX1 and the risk for prostate cancer.
|
20852942 |
2011 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We genotyped men with localized/regional prostate cancer for 26 loci across eight genes that are central to cellular antioxidant defence: glutathione peroxidase (GPX1, GPX4), peroxisome proliferator-activated receptor γ coactivator (PPARGC1A, PPARGC1B), SOD1, SOD2, and SOD3, and 'X-ray repair complementing defective repair in Chinese hamster cell 1' (XRCC1).
|
20477822 |
2011 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Asp/Asp of XPG and Gln/Gln of XRCC1 in combination showed statistically increased risk of prostate cancer in cases (OR 3.29, 95% CI 1.09-10.16, P = 0.032).
|
21670956 |
2012 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the potential prognostic roles of p53 (codon 72) and XRCC1 (codons 194, 280, and 399) polymorphisms in clinical localized prostate cancer after radical prostatectomy.
|
18006764 |
2007 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined the association between PC risk with nonsynonymous SNPs (nsSNPs) in 5 genes involved in 3 DNA-repair pathways: (1) base excision repair (BER): hOGG1 C1245G (Ser326Cys) and XRCC1 G28152A (Arg399Gln); (2) nucleotide excision repair (NER): XPD G23591A (Asp312Asn); (3) homologous recombination repair: RAD51 G135C (in 5' untranslated region) and XRCC3 C18067T (Thr241Met).
|
19914098 |
2012 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our case-control study revealed a significant association between the XRCC1-Arg399Gln polymorphism and PCa risk.
|
30160806 |
2018 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in subgroup analysis we found a suggestion that XRCC1 399Gln allele might be a low-penetrent risk factor for PCa only in Asian men.
|
21647176 |
2011 |
Prostate carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The decreased risk we observed with the hOGG1 326 Cys/Cys genotype confirms an earlier report and the further reduced risk found with the CYP1B1 (432 Leu/Leu or Leu/Val)-hOGG1 (326 Cys/Cys)-XRCC1 (Arg/Arg or Arg/Gln) genotype combination may lend new insights to the importance of ROS generated from non-receptor-mediated estrogenic mechanisms in more aggressive prostate cancer.
|
16569655 |
2006 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the genetic polymorphisms in XRCC1 may affect the outcome in patients who received radiotherapy for localized prostate cancer.
|
20495366 |
2010 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found that the XRCC1-Arg399Gln AA and the MGMT-Leu84Phe CT+TT genotypes were associated with an increased risk of prostate cancer [odds ratio (OR), 2.18; 95% confidence interval (CI), 0.99-4.81 and OR, 1.99; 95% CI, 1.19-3.34, respectively].
|
16030105 |
2005 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
X-ray repair cross-complementing group 1 (XRCC1) Arg399Gln polymorphism (rs25487) has been reported to be related to Pca.
|
25262700 |
2015 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significantly increased risk of prostate cancer was observed in white men with the XRCC1(399Gln) allele (OR 1.6, 95% CI 1.1 to 2.4).
|
16406883 |
2006 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We conclude that the XRCC1 Arg280His polymorphism may be protective against the development of high-grade late toxicity after radiotherapy in prostate cancer patients.
|
21345510 |
2011 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the meta-analysis suggests that there is no obvious association between XRCC1 Arg194Trp polymorphism and prostate cancer risk.
|
24492938 |
2014 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We found a somewhat lower prostate cancer risk for men with one or two copies of the variant alleles at the XRCC1 codons 194 and 399 than for those who were homozygous for the common allele [codon 194: odds ratio (OR) = 0.8; 95% confidence interval (CI), 0.4-1.8 and codon 399: OR = 0.8; 95% CI, 0.5-1.3].
|
12433703 |
2002 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest a positive association of XRCC1 exon 9 and XPD exon 10 genotypes that may play an important role in the pathophysiology and may modulate the risk of PCa.
|
20070155 |
2010 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lycopene intake and prostate cancer risk: effect modification by plasma antioxidants and the XRCC1 genotype.
|
16965236 |
2006 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the c.910A>G polymorphism of the XRCC1 gene is associated with susceptibility to Pca in Chinese men, the G-allele conferring higher risk.
|
23244143 |
2012 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To determine whether the XRCC1 (codon Arg399Gln) and XPD (codon Asp312Asn and codon Lys751Gln) polymorphisms are associated with prostate cancer susceptibility, we genotyped these polymorphisms in a primarily Caucasian sample of 506 sibships (n = 1,117) ascertained through a brother with prostate cancer.
|
14744728 |
2004 |
Prostate carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Pooled data from two population-based studies (1,457 cases and 1,351 controls) were analyzed to examine associations between 28 single-nucleotide polymorphisms (SNPs) in nine DNA repair genes (APEX1, BRCA2, ERCC2, ERCC4, MGMT, MUTYH, OGG1, XPC, and XRCC1) and prostate cancer risk.
|
19902366 |
2010 |