Disease: Bipolar Disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASDB Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease CTD_human Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASCAT Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder. 18711365 2008
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The ZNF804A and CACNA1C loci appear to influence risk for both disorders, a finding that supports the hypothesis that schizophrenia and BD are not aetiologically distinct. 19521722 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Strong genetic associations have been reported at common polymorphisms within ANK3 and CACNA1C in bipolar disorder and ZNF804A in schizophrenia and a relatively specific association between common variation in GABA(A) receptor genes and cases with features of both bipolar disorder and schizophrenia. 19329560 2009
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Several genome-wide linkage studies in BPAD and migraine have shown overlapping regions of linkage on chromosomes, and two functionally similar voltage-dependent calcium channels CACNA1A and CACNA1C have been identified in familial hemiplegic migraine and recently implicated in two whole genome BPAD association studies, respectively. 19819557 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Recent genome-wide association studies have associated polymorphisms in the gene CACNA1C, which codes for Ca(v)1.2, with a bipolar disorder and depression diagnosis. 20723887 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Strong evidence (P=7.0 × 10(-7)) of association at the polymorphism rs1006737 (within CACNA1C, the gene encoding the α-1C subunit of the L-type voltage-gated calcium channel) with the risk of bipolar disorder (BD) has recently been reported in a meta-analysis of three genome-wide association studies of BD, including our BD sample (N=1868) studied within the Wellcome Trust Case Control Consortium. 19621016 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The risk-associated SNP in CACNA1C maps to circuitries implicated in genetic risk for bipolar disorder and schizophrenia. 20819988 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be overrepresented in patients suffering from bipolar disorder, schizophrenia or major depression. 19781653 2010
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease CTD_human Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Here we sought to investigate the influence of CACNA1C polymorphism on key subcortical brain structures implicated in the pathophysiology of BD. 21292451 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease CTD_human In a joint analysis with a bipolar disorder sample (16,374 affected individuals and 14,044 controls), three loci reached genome-wide significance: CACNA1C (rs4765905, P = 7.0 × 10(-9)), ANK3 (rs10994359, P = 2.5 × 10(-8)) and the ITIH3-ITIH4 region (rs2239547, P = 7.8 × 10(-9)). 21926974 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Genome-wide association studies have reported strong evidence of association between the polymorphisms rs10994336[T] in the ANK3 gene and rs1006737[A] in the CACNA1C gene and risk of bipolar disorder. 21395576 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASCAT Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder. 20351715 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASDB Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE Developments in genotyping technology and efforts to combine data from different studies have helped in identifying chromosomes 6q16-q25, 13q, and 16p12 as probable susceptibility loci for bipolar disorder and confirmed CACNA1C and ANK3 as susceptibility genes for bipolar disorder. 21837483 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE Recent genetic studies found the A allele of the variant rs1006737 in the alpha 1C subunit of the L-type voltage-gated calcium channel (CACNA1C) gene to be over-represented in patients with psychosis, including schizophrenia, bipolar disorder and major depressive disorder. 21078228 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The rs10994336 ANK3 and rs1006737 CACNA1C genetic variants have recently been identified as the most consistent, genome-wide significant risk factors for bipolar disorder, while the CACNA1C variant has also been associated with schizophrenia and major depression. 21676128 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE ANK3, CACNA1C and ZNF804A gene variants in bipolar disorders and psychosis subphenotype. 21767209 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease GWASCAT Finally, a combined GWAS analysis of schizophrenia and bipolar disorder yielded strong association evidence for SNPs in CACNA1C and in the region of NEK4-ITIH1-ITIH3-ITIH4. 21926972 2011
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The effects of CACNA1C gene polymorphism on spatial working memory in both healthy controls and patients with schizophrenia or bipolar disorder. 22012475 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 GeneticVariation disease BEFREE The CACNA1C genotype did not impact on amygdala or hippocampus volume neither in BD nor controls. 22464935 2012
CUI: C0005586
Disease: Bipolar Disorder
Bipolar Disorder 		0.700 Biomarker disease BEFREE ANK3 and CACNA1C--missing genetic link for bipolar disorder and major depressive disorder in two German case-control samples. 22647524 2012