Frasier Syndrome
|
0.080 |
Biomarker
|
disease |
BEFREE |
Frasier syndrome is caused by defective alternative splicing of WT1 leading to an altered ratio of WT1 +/-KTS splice isoforms.
|
9499425 |
1998 |
Nephroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Here, we show that WT1 -KTS isoforms associate and synergize with SF-1 to promote MIS expression.
|
9590178 |
1998 |
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
We demonstrate that introduction of EWS/WT1(-KTS) into NIH3T3 cells causes their tumorigenic transformation as determined by: formation of transformed foci on a monolayer of cells; anchorage-independent growth; and tumor formation in nude mice.
|
9591781 |
1998 |
Frasier Syndrome
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
KTS (lysine-threonine-serine) splice site mutations in WT1 intron 9 have been described in patients with Frasier syndrome, another rare syndrome defined by focal and segmental glomerulosclerosis (FSGS), XY pseudohermaphroditism, and frequent occurrence of gonadoblastoma.
|
10505700 |
1999 |
Gonadoblastoma
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
KTS (lysine-threonine-serine) splice site mutations in WT1 intron 9 have been described in patients with Frasier syndrome, another rare syndrome defined by focal and segmental glomerulosclerosis (FSGS), XY pseudohermaphroditism, and frequent occurrence of gonadoblastoma.
|
10505700 |
1999 |
Focal glomerulosclerosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
KTS (lysine-threonine-serine) splice site mutations in WT1 intron 9 have been described in patients with Frasier syndrome, another rare syndrome defined by focal and segmental glomerulosclerosis (FSGS), XY pseudohermaphroditism, and frequent occurrence of gonadoblastoma.
|
10505700 |
1999 |
Frasier Syndrome
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
Exon 9 mutations in the WT1 gene, without influencing KTS splice isoforms, are also responsible for Frasier syndrome.
|
10571943 |
1999 |
Nephroblastoma
|
0.090 |
GeneticVariation
|
disease |
BEFREE |
In this study, two +KTS deletion mutants of WT1 were made as well as a WT1 mutant mimicking a mutation found in a patient who had diffuse mesangial sclerosis, end stage renal failure and Wilms tumor.
|
10586431 |
1999 |
Frasier Syndrome
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
From these results, we suggest that the alteration of +KTS WT1 expression be responsible for the rapid progression of renal diseases in DDS and FS.
|
10586431 |
1999 |
Childhood Kidney Wilms Tumor
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
In this study, two +KTS deletion mutants of WT1 were made as well as a WT1 mutant mimicking a mutation found in a patient who had diffuse mesangial sclerosis, end stage renal failure and Wilms tumor.
|
10586431 |
1999 |
Kidney Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
From these results, we suggest that the alteration of +KTS WT1 expression be responsible for the rapid progression of renal diseases in DDS and FS.
|
10586431 |
1999 |
Diffuse mesangial sclerosis (disorder)
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In this study, two +KTS deletion mutants of WT1 were made as well as a WT1 mutant mimicking a mutation found in a patient who had diffuse mesangial sclerosis, end stage renal failure and Wilms tumor.
|
10586431 |
1999 |
Denys-Drash Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
From these results, we suggest that the alteration of +KTS WT1 expression be responsible for the rapid progression of renal diseases in DDS and FS.
|
10586431 |
1999 |
Nephroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
WT1 transcript analysis showed reversal of the normal positive/negative KTS (lysine, threonine, and serine) isoform ratio, confirming the diagnosis of FS.
|
12050205 |
2002 |
Frasier Syndrome
|
0.080 |
Biomarker
|
disease |
BEFREE |
WT1 transcript analysis showed reversal of the normal positive/negative KTS (lysine, threonine, and serine) isoform ratio, confirming the diagnosis of FS.
|
12050205 |
2002 |
Nephroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
This induction was EWS-WT1(-KTS)-specific, and more importantly, TALLA-1 protein was expressed in the three independent cases of DSRCT.
|
14633590 |
2003 |
Desmoplastic Small Round Cell Tumor
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
This induction was EWS-WT1(-KTS)-specific, and more importantly, TALLA-1 protein was expressed in the three independent cases of DSRCT.
|
14633590 |
2003 |
Ewings sarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
This induction was EWS-WT1(-KTS)-specific, and more importantly, TALLA-1 protein was expressed in the three independent cases of DSRCT.
|
14633590 |
2003 |
Nephroblastoma
|
0.090 |
Biomarker
|
disease |
BEFREE |
Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro.
|
16630117 |
2006 |
Childhood Kidney Wilms Tumor
|
0.040 |
Biomarker
|
disease |
BEFREE |
Wilms' tumor gene WT1 17AA(-)/KTS(-) isoform induces morphological changes and promotes cell migration and invasion in vitro.
|
16630117 |
2006 |
Malignant Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Constitutive expression of the WT1 17AA(-)/KTS(-) isoform also induced morphological changes in five (one gastric, one esophageal, two breast and one fibrosarcoma) of eight cancer cell lines examined.
|
16630117 |
2006 |
Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Constitutive expression of the WT1 17AA(-)/KTS(-) isoform also induced morphological changes in five (one gastric, one esophageal, two breast and one fibrosarcoma) of eight cancer cell lines examined.
|
16630117 |
2006 |
Adult Fibrosarcoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Constitutive expression of the WT1 17AA(-)/KTS(-) isoform also induced morphological changes in five (one gastric, one esophageal, two breast and one fibrosarcoma) of eight cancer cell lines examined.
|
16630117 |
2006 |
Tumor Cell Invasion
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
In the WT1 17AA(-)/KTS(-) isoform-transduced TYK cells, cell-substratum adhesion was suppressed, and cell migration and in vitro invasion were enhanced compared to that in mock vector-transduced TYK cells.
|
16630117 |
2006 |
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Constitutive expression of the WT1 17AA(-)/KTS(-) isoform also induced morphological changes in five (one gastric, one esophageal, two breast and one fibrosarcoma) of eight cancer cell lines examined.
|
16630117 |
2006 |