Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
A recent report demonstrates that plasma platelet-activating factor acetylhydrolase activity increases in men and women with stable angina or acute coronary syndromes, supporting previously published data that plasma levels of the protein are independently and positively associated with the risk of coronary artery disease.
|
15166791 |
2004 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The serum levels of ICAM-1, YKL-40, and Lp-PLA2 were correlated with different clinical types of CHD, but not well correlated the severity and extent of artery stenosis, suggesting that ICAM-1, YKL-40, and Lp-PLA2 might be involved in occurrence of instability of atherosclerotic plaque, and might reflect the severity of CHD mostly through reflecting the plaque stability.
|
29893361 |
2018 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lp-PLA2 mass was associated with CHD risk (HR: 1.02-1.24, 95% CI: 1.02-1.24, P=0.021).
|
28514697 |
2017 |
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
In summary, an independent association of increased plasma Lp-PLA(2) activity with CHD and MI existed in this Chinese Han Population.
|
19034521 |
2009 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression analysis showed close associations between MI with Lp-PLA2 and GG genotype at D166E, with odds ratios of 1.239 (1.023-2.017) and 9.863 (4.107-21.331), which suggested they were independent risk factors for the development of coronary heart disease.
|
31115024 |
2019 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Therefore, it is doubtful whether Lp-PLA2 will constitute a therapeutic target for the prevention of CHD.
|
29332572 |
2018 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease.
|
15115767 |
2004 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Since homozygosity for V379 occurs in only 5-6% of subjects, this genotype is not a major determinant of population genetic risk of CHD, but the association of this genotype with low levels of Lp-PLA(2), strongly support the pro-inflammatory causative, and not consequential, role of Lp-PLA(2) in CHD.
|
12801611 |
2003 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Lipoprotein-associated phospholipase A2 (Lp-PLA<sub>2</sub>) is a marker of vascular inflammation associated with coronary heart disease and stroke.
|
28900364 |
2017 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Larger association studies, identification of single-nucleotide polymorphisms with larger effects, or randomized trials of specific Lp-PLA2 inhibitors are needed to confirm or refute a contributory role for Lp-PLA2 in CHD.
|
20479152 |
2010 |
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lp-PLA2 activity has important clinical value in CHD.
|
30770710 |
2019 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Although epidemiology studies consistently support a relationship between plasma Lp-PLA2 levels and susceptibility to coronary heart disease this is not the case for Lp-PLA2 polymorphisms.
|
15990594 |
2005 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Identification of the G994--> T missense in exon 9 of the plasma platelet-activating factor acetylhydrolase gene as an independent risk factor for coronary artery disease in Japanese men.
|
9472966 |
1998 |
Coronary heart disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Lp-PLA2 activity is an independent predictor of CHD risk and MS in a sample of subjects with diabetes mellitus.
|
16438975 |
2006 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Methods In 72,657 patients with coronary heart disease and 110,218 controls in 23 epidemiological studies, we genotyped five functional variants: four rare loss-of-function mutations (c.109+2T > C (rs142974898), rs144983904" genes_norm="7941">Arg82His (rs144983904), rs76863441" genes_norm="7941">Val279Phe (rs76863441), Gln287Ter (rs140020965)) and one common modest-impact variant (Val379Ala (rs1051931)) in PLA2G7, the gene encoding Lp-PLA<sub>2</sub>.
|
27940953 |
2017 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Association between lipoprotein-associated phospholipase A2 gene polymorphism and coronary artery disease in the Chinese Han population.
|
21834908 |
2011 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In the more general setting of population studies, however, it is clear that Lp-PLA(2) is a positive risk factor for coronary disease and measurements of its mass may contribute to the prediction of coronary heart disease risk, especially in individuals with low LDL cholesterol levels.
|
12865731 |
2003 |
Coronary heart disease
|
0.500 |
PosttranslationalModification
|
disease |
BEFREE |
Receiver operating characteristic (ROC) curves showed that PLA2G7 methylation could predict the risk of CHD in females (area under curve (AUC) = 0.912, P = 2.40E-5).
|
23555769 |
2013 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We investigated the association between early-onset MI, lipid levels and 20 single nucleotide polymorphisms (SNPs) in the candidate genes ADIPOQ, APOA5, ALOX5AP, CYBA, IL6, LPL, PECAM1, PLA2G2A and PLA2G7, chosen because of previously reported associations with Coronary Heart Disease (CHD) or with CHD risk factors.
|
21130994 |
2011 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
These data suggested that the V279F polymorphism in LP-PLA2 gene may contribute to CHD development.
|
21107710 |
2011 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Discussed in this review is the accumulating evidence supporting the view that Lp-PLA2 is a potential biomarker of coronary heart disease and plays and an important proinflammatory role in the progression of atherosclerosis.
|
11963798 |
2002 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Four of the polymorphisms (in APOC1, CELSR2, SCARB1, ZNF259), but not PLA2G7, were significantly associated with CHD in a second study.
|
22003152 |
2012 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Deciphering the Causal Role of sPLA2s and Lp-PLA2 in Coronary Heart Disease.
|
26338298 |
2015 |
Coronary heart disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Studies in subjects with coronary artery disease have also shown associations between Lp-PLA2 and cardiovascular risk.
|
15713711 |
2005 |
Coronary heart disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
14 association studies focusing on three polymorphisms (A379V, V279F and R92H) in PLA2G7 gene and risk of CHD were included in meta-analysis, covering a total of 8,280 cases and 5,656 controls.
|
20926117 |
2010 |