|
Malignant neoplasm of breast
|
0.310 |
GeneticVariation
|
disease |
UNIPROT |
|
|
|
|
Malignant neoplasm of colon and/or rectum
|
0.020 |
Biomarker
|
disease |
BEFREE |
SUV39H2 promotes colorectal cancer proliferation and metastasis via tri-methylation of the SLIT1 promoter.
|
29458143 |
2018 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
SUV39H2 might be a potential oncogene in lung adenocarcinoma, mediating tumorigenesis and metastasis.
|
30348215 |
2018 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
SUV39H2 is overexpressed in various types of human cancer, whereas it is almost undetectable in normal adult tissues, except testis.
|
30542727 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
AlteredExpression
|
group |
BEFREE |
SUV39H2 is overexpressed in various types of human cancer, whereas it is almost undetectable in normal adult tissues, except testis.
|
30542727 |
2019 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
A better understanding of the SUV39H2 will be beneficial to the development of molecular-targeted therapies in cancer.
|
30719171 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
A better understanding of the SUV39H2 will be beneficial to the development of molecular-targeted therapies in cancer.
|
30719171 |
2019 |
|
Parakeratosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A splice site variant in the SUV39H2 gene in Greyhounds with nasal parakeratosis.
|
29423952 |
2018 |
|
Malignant Neoplasms
|
0.050 |
GeneticVariation
|
group |
BEFREE |
At last, RNaseq analysis identifies a variety of SUV39H2 downstream genes related with cancer, in which, NRIP1 is identified as a critical downstream target of SUV39H2 in NPC.
|
30709585 |
2019 |
|
Primary malignant neoplasm
|
0.040 |
GeneticVariation
|
group |
BEFREE |
At last, RNaseq analysis identifies a variety of SUV39H2 downstream genes related with cancer, in which, NRIP1 is identified as a critical downstream target of SUV39H2 in NPC.
|
30709585 |
2019 |
|
Neoplasm Metastasis
|
0.020 |
Biomarker
|
phenotype |
BEFREE |
Both in vitro and in vivo assays demonstrated that ectopically expressed SUV39H2 enhanced CRC proliferation and metastasis, while SUV39H2 knockdown inhibited CRC proliferation and metastasis.
|
29458143 |
2018 |
|
Congenital chromosomal disease
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Conversely, high expression of SUV39H2 correlated with cytogenetic abnormalities in CLL patients.
|
28833505 |
2017 |
|
Chronic Lymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Conversely, high expression of SUV39H2 correlated with cytogenetic abnormalities in CLL patients.
|
28833505 |
2017 |
|
Malignant Neoplasms
|
0.050 |
AlteredExpression
|
group |
BEFREE |
Dysregulation of SUV39H2 expression has been observed in several types of cancers.
|
30348215 |
2018 |
|
Systemic Scleroderma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Expression of JHDM2A was significantly increased but HDAC2, HDAC7, and, SUV39H2 were significantly down-regulated in SSc B cells relative to controls.
|
23891737 |
2013 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Finally, to assess the potential oncogenic role of SUV39H2, we employed the invasion assay and clone formation assay in vitro and tumorigenesis assays in mouse models in vivo.
|
30348215 |
2018 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
GWASDB |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
|
Migraine Disorders
|
0.100 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide meta-analysis identifies new susceptibility loci for migraine.
|
23793025 |
2013 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
However, neither the genomic landscape nor the clinical significance of SUV39H2 in lung adenocarcinoma has been probed comprehensively.
|
30348215 |
2018 |
|
Colorectal Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
In summary, we propose that SUV39H2 can predict CRC patient prognosis and stimulate CRC malignant phenotypes via SLIT1 promoter tri-methylation.
|
29458143 |
2018 |
|
Malignant Bone Neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the present study, increased SUV39H2 expression levels were observed in osteosarcoma, the most common primary bone cancer in children and adolescents, and the knockdown of SUV39H2 expression by specific small interfering RNAs in osteosarcoma cells markedly suppressed cancer cell growth and led to a notable reduction in cell viability.
|
30542727 |
2019 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated genetic polymorphisms of the SETD7, SUV39H1, and SUV39H2 methyltransferases as predictors of risk for micro- and macrovascular complications in type 1 diabetes.
|
21896933 |
2011 |
|
Malignant Neoplasms
|
0.050 |
Biomarker
|
group |
BEFREE |
Mutation analysis of HDAC1, HDAC2, SUV39H1, and SUV39H2 revealed only two out of 181 cancer samples (both cell lines) with significant coding-sequence alterations.
|
16638127 |
2006 |
|
Primary malignant neoplasm
|
0.040 |
Biomarker
|
group |
BEFREE |
Mutation analysis of HDAC1, HDAC2, SUV39H1, and SUV39H2 revealed only two out of 181 cancer samples (both cell lines) with significant coding-sequence alterations.
|
16638127 |
2006 |
|
Lung Neoplasms
|
0.010 |
GeneticVariation
|
group |
LHGDN |
Novel polymorphisms in the SUV39H2 histone methyltransferase and the risk of lung cancer.
|
16774942 |
2006 |