|
Bacteremia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These data indicate that <i>Pg</i> bacteria may enhance paracellular penetration through oral mucosa in part by targeting the expression of GRHL2 in the oral epithelial cells, which then impairs the epithelial barrier by inhibition of junction protein expression, resulting in increased alveolar tissue destruction and systemic bacteremia.
|
31340691 |
2019 |
|
Lymphatic Metastasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
High expression of GRHL2 was significantly associated with histological differentiation (P=0.018) and lymphatic metastasis (P=0.024).
|
30675204 |
2019 |
|
Skin Ulcer
|
0.010 |
AlteredExpression
|
phenotype |
BEFREE |
Administration of 4 transcription factors (DNP63A, GRHL2, TFAP2A, and cMYC) expressed via adeno-associated viral vectors enabled generation of epithelial cells and tissues, thereby acheiving de novo epithelialization from the surfaces of cutaneous ulcers in a mouse model.
|
31255469 |
2019 |
|
Mouth Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Using epithelial-specific Grhl2 conditional knockout mice, we exposed wild-type (WT) and Grhl2 KO mice to 4-nitroquinolin 1-oxide (4-NQO), which led to induction of FoxM1B in the tongue tissues and rampant oral tumor development in the WT mice.
|
29443638 |
2018 |
|
Malignant neoplasm of oropharynx
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these results indicate that HPV-16 induces FoxM1B in part through GRHL2 transcriptional activity and that elevated FoxM1B level is required for oropharyngeal cancer development.
|
29443638 |
2018 |
|
Adrenoleukodystrophy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Transcription of MIR122 is inhibited by GRHL2, which is increased in livers of mice and patients with ALD.
|
28987423 |
2018 |
|
Exencephaly
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Grainyhead-like genes represent candidates for involvement in NTDs based on the presence of SB and exencephaly in mice carrying loss-of-function alleles of Grhl2 or Grhl3.
|
30189017 |
2018 |
|
Hypopharyngeal Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Retroviral expression of HPV-16 E6 and/or E7 in NHOKs, TECs, and hypopharyngeal carcinoma cells (FaDu) revealed induction of FoxM1B and GRHL2 by the E6 protein but not E7.
|
29443638 |
2018 |
|
Oropharyngeal Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Collectively, these results indicate that HPV-16 induces FoxM1B in part through GRHL2 transcriptional activity and that elevated FoxM1B level is required for oropharyngeal cancer development.
|
29443638 |
2018 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
These findings confirm that GRHL2 plays an important role in regulating cell proliferation and migration in NSCLC.
|
28979695 |
2017 |
|
Esophageal Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The results demonstrated that abnormal expression of GRHL2 is common in EC, and low expression of GRHL2 accompanied by a high expression of HIF-1α indicates poor prognosis.
|
28435293 |
2017 |
|
Prostatic Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
GRHL2 colocalized with AR in prostate tumors and was frequently amplified and upregulated in prostate cancer.
|
28473532 |
2017 |
|
Psoriasis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Moreover, the expression of miR-194 and GRHL2 was inversely correlated in psoriasis lesional skin.
|
28040329 |
2017 |
|
Esophageal carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that abnormal expression of GRHL2 is common in EC, and low expression of GRHL2 accompanied by a high expression of HIF-1α indicates poor prognosis.
|
28435293 |
2017 |
|
Malignant neoplasm of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Grainyhead-like 2 (GRHL2) regulates epithelial plasticity in pancreatic cancer progression.
|
28960866 |
2017 |
|
Malignant neoplasm of prostate
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GRHL2 colocalized with AR in prostate tumors and was frequently amplified and upregulated in prostate cancer.
|
28473532 |
2017 |
|
Secondary malignant neoplasm of liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
GRHL2 regulates epithelial plasticity along with stemness in PDAC, both of which are crucial for metastasis, implicating the possibility of GRHL2 as a therapeutic target for PDAC liver metastasis.
|
28960866 |
2017 |
|
Malignant neoplasm of esophagus
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results demonstrated that abnormal expression of GRHL2 is common in EC, and low expression of GRHL2 accompanied by a high expression of HIF-1α indicates poor prognosis.
|
28435293 |
2017 |
|
Prostate carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
GRHL2 colocalized with AR in prostate tumors and was frequently amplified and upregulated in prostate cancer.
|
28473532 |
2017 |
|
Epithelial ovarian cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our data are indicative for a strong oncogenic potential of the GRHL2 gene in EOC progression and support recent findings on the role of GRHL2 as one of the major phenotypic stability factors (PSFs) that stabilize the highly aggressive/metastatic hybrid epithelial/mesenchymal (E/M) phenotype of cancer cells.
|
28278050 |
2017 |
|
ovarian neoplasm
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In this study, we report that GRHL2 is strongly overexpressed in both low malignant potential (LMP) and HG serous epithelial ovarian tumors, which probably correlates with its hypomethylated status.
|
28278050 |
2017 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
GRHL2 regulates epithelial plasticity along with stemness in PDAC, both of which are crucial for metastasis, implicating the possibility of GRHL2 as a therapeutic target for PDAC liver metastasis.
|
28960866 |
2017 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
GRHL2 suppresses tumor metastasis via regulation of transcriptional activity of RhoG in non-small cell lung cancer.
|
28979695 |
2017 |
|
Carcinoma, Ovarian Epithelial
|
0.010 |
Biomarker
|
disease |
BEFREE |
Taken together, our data are indicative for a strong oncogenic potential of the GRHL2 gene in EOC progression and support recent findings on the role of GRHL2 as one of the major phenotypic stability factors (PSFs) that stabilize the highly aggressive/metastatic hybrid epithelial/mesenchymal (E/M) phenotype of cancer cells.
|
28278050 |
2017 |
|
Dyskeratosis Congenita
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our case series shows that biallelic variants in USB1, LIG4 and GRHL2, the genes mutated in poikiloderma with neutropenia, LIG4/Dubowitz syndrome and the recently recognized ectodermal dysplasia/short stature syndrome, respectively, cause features that overlap with dyskeratosis congenita.
|
27612988 |
2016 |